| Identification | More | [Name]
N-Boc-(S)-2-amino-3-benzyloxy-1-propanol | [CAS]
79069-15-1 | [Synonyms]
BOC-D-SER(BZL)-OL
BOC-D-SERINOL(BZL)
BOC-O-BENZYL-D-SERINOL
BOC-O-BENZYL-L-SERINOL
BOC-(R)-2-AMINO-3-PHENYLMETHOXY-1-PROPANOL
BOC-(S)-2-AMINO-3-PHENYLMETHOXY-1-PROPANOL
BOC-SER(BZL)-OL
BOC-SERINOL(BZL)
N-ALPHA-T-BOC-O-BENZYL-D-SERINOL
N-ALPHA-T-BOC-O-BENZYL-L-SERINOL
N-BOC-D-SER(BZL)-OL
N-BOC-D-SER(BZL)-OLN-BOC-(S)-2-AMINO-3-BENZYLOXY-1-PROPANOL
N-BOC-L-SER(BZL)-OL
N-BOC-L-SER(BZL)-OL-N-BOC-(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL
N-BOC-(R)-2-AMINO-3-BENZYLOXY-1-PROPANOL
N-T-BUTOXYCARBONYL-O-BENZYL-D-SERINOL
N-T-BUTOXYCARBONYL-O-BENZYL-L-SERINOL
(R)-(+)-3-BENZYLOXY-2-(TERT-BUTOXYCARBONYLAMINO)-1-PROPANOL
N-BOC-(S)-2-AMINO-3-BENZYLOXY-1-PROPANOL
N-alpha-t-Butyloxycarbonyl-O-benzyl-D-serinol | [Molecular Formula]
C15H23NO4 | [MDL Number]
MFCD00235944 | [Molecular Weight]
281.35 | [MOL File]
79069-15-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
66-69 °C(lit.)
| [alpha ]
-14 º (c=1 in chloroform) | [Boiling point ]
443.1±40.0 °C(Predicted) | [density ]
1.105 | [storage temp. ]
Store at 0-5°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
11.58±0.46(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C15H23NO4/c1-15(2,3)20-14(18)16-13(9-17)11-19-10-12-7-5-4-6-8-12/h4-8,13,17H,9-11H2,1-3H3,(H,16,18)/t13-/m0/s1 | [InChIKey]
MSIDLARYVJJEQY-ZDUSSCGKSA-N | [SMILES]
C(OC(C)(C)C)(=O)N[C@@H](CO)COCC1=CC=CC=C1 | [CAS DataBase Reference]
79069-15-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white solid | [Synthesis]
Under an atmosphere of argon, to a solution of 2,5-dioxopyrrolidin-1-yl O-benzyl-N-t-butoxycarbonyl-L-serinate (4.41 g) in tetrahydrofuran(30 mL) was added sodium borohydride (644 mg) in ice bath and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, which was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated ammonium chloride solution and brine, dried over anhydrous magnesium sulfate, and concentrated to give N-Boc-(S)-2-amino-3-benzyloxy-1-propanol.
| [References]
[1] Synthetic Communications, 1996, vol. 26, # 13, p. 2511 - 2522
[2] Nucleosides and Nucleotides, 1999, vol. 18, # 8, p. 1845 - 1861
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 702 - 713 |
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