| Identification | More | [Name]
Nefazodone | [CAS]
83366-66-9 | [Synonyms]
2-[3-[4-(3-CHLOROPHENYL)-1-PIPERAZINYL]PROPYL]-5-ETHYL-2,4-DIHYDRO-4-(2-PHENOXYETHYL)-3H-1,2,4-TRIAZOL-3-ONE HYDROCHLORIDE
BMY-13754
MJ-13754-1
NEFAZODONE
NEFAZODONE HCL
NEFAZODONE HYDROCHLORIDE
SERZONE
3h-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy
l)-5-ethyl-4-(2-phenoxyethyl)-
Nefazodone base
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one, Hydrochloride
3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-
Nefazodone (base and/or unspecified salts)
Dutonin
MJ-13754-I
2-[3-[4-(3-Chlorophenyl)piperazino]propyl]-4-(2-phenoxyethyl)-5-ethyl-2H-1,2,4-triazole-3(4H)-one | [Molecular Formula]
C25H32ClN5O2 | [MDL Number]
MFCD00935760 | [Molecular Weight]
470.01 | [MOL File]
83366-66-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Crystalline Solid | [Melting point ]
180-182°C | [Boiling point ]
599.6±60.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: ~11 mg/mL at 60 °C
| [form ]
solid
| [pka]
pKa 6.5 (Uncertain) | [color ]
white
| [Usage]
A selective serotonin 5-HT2 receptor antagonist. An antidepressant | [CAS DataBase Reference]
83366-66-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Nefazodone(83366-66-9) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline Solid | [Originator]
Dutonin,Bristol-Myers Squibb,USA | [Uses]
A selective serotonin 5-HT2 receptor antagonist. An antidepressant | [Definition]
ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic. | [Brand name]
Serzone (Bristol-Myers Squibb). | [Therapeutic Function]
Antidepressant | [Biological Functions]
Although nefazodone (Serzone) is structurally related
to trazodone, it is less sedating. It does not block α1-
adrenoreceptors, and its use is not associated with priapism.
Nefazodone inhibits the neuronal reuptake of
serotonin and blocks 5HT2A receptors. Its short half-life
requires dosing twice a day. Nefazodone is
not associated with weight gain or sexual dysfunction. It
inhibits the cytochrome P450 3A4 isoenzyme that is responsible
for 50% of known oxidative metabolism, and
therefore, nefazodone can elevate levels of drugs dependent
on this pathway for metabolism. |
|
| Company Name: |
Mainchem Co., Ltd.
|
| Telephone: |
+86-0592-6210733 |
| Website: |
https://www.mainchem.com |
|