| Identification | More | [Name]
2-Methyl-2-thiopseudourea sulfate | [CAS]
867-44-7 | [Synonyms]
S-METHYL-ISO-THIOUREA
2-methyl-2-thio-pseudouresulfate(2:1)
carbamimidothioicacid,methylester,sulfate(2:1)
methylcarbamimidothioatesulfate(2:1)
Methylisothioureahydrogensulfate
s-methylisothioureasulfate(2:1)
s-methylthiouroniumsulfate(2:1)
2-Methyl-2-thiopseudourea sulphate
S-EIT hemihydrate
S-MethyliSothourea Sulfate
S-METHYLISOTHIOUREA HEMISULFATE NITRIC O XIDE SYNTHASE
S-Methylthioureasulfate=2-Methyl-2-thiopseudoureasulfate
S-Methylisothiouroniumsulfate,98%
5-METHYLISOTHIOUREAHEMISULFATE
METHYLTHIOURONIUMSULPHATE
METHYLTHIURONIUMSULPHATE
2-methyl-2-thio-pseudoure sulfate
methylcarbamimidothioate sulfate
methylsulfanylmethanimidamide
2-METHYL-2-THIOSEUDOUREA SULFATE | [EINECS(EC#)]
212-759-7 | [Molecular Formula]
C2H8N2O4S2 | [MDL Number]
MFCD00129752 | [Molecular Weight]
188.23 | [MOL File]
867-44-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
240-241 °C (dec.)(lit.)
| [density ]
1.28 | [Fp ]
3℃ | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
H2O: 0.1 g/mL, clear, colorless
| [form ]
Crystals or Crystalline Powder | [pka]
pK1:9.83(＋1) (25°C) | [color ]
White | [PH]
5.5 (260g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
260 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [BRN ]
3917217 | [InChI]
1S/2C2H6N2S.H2O4S/c2*1-5-2(3)4;1-5(2,3)4/h2*1H3,(H3,3,4);(H2,1,2,3,4) | [InChIKey]
BZZXQZOBAUXLHZ-UHFFFAOYSA-N | [SMILES]
CSC(N)=N.CSC(N)=N.OS(O)(=O)=O | [CAS DataBase Reference]
867-44-7(CAS DataBase Reference) | [EPA Substance Registry System]
867-44-7(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P264-P270-P301+P312a-P330-P501a | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
UM9200000
| [TSCA ]
Yes | [HS Code ]
29309070 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Raw materials And Preparation Products | Back Directory | [Preparation Products]
5-methoxy-2-(methylthio)pyrimidin-4-ol ,97%-->4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97%-->1-Methyl-3-nitro-1-nitrosoguanidine-->Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate-->Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate-->Aminoguanidine bicarbonate-->1,4-Dihydro-2-(methylthio)-4-oxo-5-pyrimidine-carboxylate acid ethyl ester-->IMINOCTADINE TRIACETATE-->5-Chloro-2-methoxypyrimidine-4-carboxylic acid-->1,1-Dimethylguanidine sulfate-->5-[2-(Methylthio)pyrimidin-4-yl]thiophene-2-sulfonyl chloride-->5-Chloro-2-(methylsulfonyl)pyrimidine-->Methyl 5-bromo-2-(methylsulfanyl)-4-pyrimidinecarboxylate, 97-->4-Methoxy-6-methyl-2-(methylsulfonyl)pyrimidine ,97%-->5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid-->5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%-->5-Bromo-2-(methylsulfonyl)pyrimidine-4-carboxylic acid-->2-(Methylthio)-4-(trifluoromethyl)pyrimidine-->4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97%-->4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile-->3-Oxo-3-thiophen-2-yl-propionic acid ethyl ester-->5-Aminopyrimidine-->5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acid-->ethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate-->4-Methoxy-6-methyl-2-(methylthio)pyrimidine-->4-Methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester-->2-(Methylsulfanyl)-5-phenylpyrimidine-->5-Methyl-2-(methylsulfonyl)pyrimidine ,97%-->Aminoguanidinium sulphate-->2-(Methylthio)ethanol-->1-(4-Methyl-2-(methylthio)pyrimidin-5-yl)ethanone-->Gabexate mesylate-->4-Amino-2-methylsulfanyl-pyrimidine-5-carboxylic acid-->Ethyl 2-(ethylthio)-4-hydroxypyrimidine-5-carboxylate-->5-Methyl-2-methylsulfanyl-pyrimidine |
| Hazard Information | Back Directory | [Description]
SMIT is a potent non-selective inhibitor of NOS isoforms in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively.1 | [Chemical Properties]
white crystalline powder | [Uses]
Intermediate of 4-Hydroxydebrisoquine. S-Methyl-isothiouronium Hemisulfate is also a reagent used in the synthesis of strobilurin-pyrimidine derivatives for their anti-proliferative activity. | [Biochem/physiol Actions]
More potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS). | [References]
[1] E. P. GARVEY. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas.[J]. The Journal of Biological Chemistry, 1994, 50 1: 26669-26676. DOI: 10.1016/s0021-9258(18)47071-8 |
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