| Identification | Back Directory | [Name]
Dihydrotanshinone I | [CAS]
87205-99-0 | [Synonyms]
DHTS
product/153057
Dihydrotanshinone I
Cannabisin A standard
15,16-Dihydrotanshine I
Dihydrotanshinone I 87205-99-0
Dihydrotanshinone Ⅰ, froM Salvia Miltiorrhiza
Dihydrotanshinone I, 15,16-Dihydrotanshinone I
Dihydrotanshinone I, 98%, from Salvia miltiorrhiza
1,6-DiMethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione
4,17-Dimethyl-15-oxagona-1,3,5(10),6,8,13-hexene-11,12-dione
(-)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione
1,6-Dimethyl-1,2,10,11-tetrahydrophenanthro[1,2-b]furan-10,11-dione
(1R)-1,6-diMethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione
Phenanthro[1,2-b]furan-10,11-dione, 1,2-dihydro-1,6-dimethyl-, (1R)- | [Molecular Formula]
C18H14O3 | [MDL Number]
MFCD03427684 | [MOL File]
87205-99-0.mol | [Molecular Weight]
278.3 |
| Chemical Properties | Back Directory | [Melting point ]
214.0 to 218.0 °C | [Boiling point ]
479.2±45.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
ethanol: soluble1mg/mL, clear, orange to red | [form ]
powder | [color ]
red | [biological source]
Salvia miltiorrhiza | [λmax]
239nm(lit.) | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChI]
1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1 | [InChIKey]
HARGZZNYNSYSGJ-JTQLQIEISA-N | [SMILES]
C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
Red powder | [Uses]
Dihydrotanshinone I, an extract from Salvia miltiorrhiza Bunge, is an anti-cancer agent which has been shown to induce apoptosis in human colorectal cancer cells. | [Definition]
ChEBI: Dihydrotanshinone I is an abietane diterpenoid. It has a role as an anticoronaviral agent. | [Biological Activity]
Tanshinone extracted from a herbSalvia miltiorrhizacommonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model. | [in vivo]
Dihydrotanshinone I (10 and 25 mg/kg) significantly attenuates atherosclerotic plaque formation, alteres serum lipid profile, decreases oxidative stress and shrinks necrotic core areas in ApoE-/- mice. Dihydrotanshinone I dramatically inhibits the enhanced expression of LOX-1, NOX4, and NF-κB in aorta[1].
Dihydrotanshinone I (1, 2, 4 mg/kg) treatment can improve cardiac function, reduce infarct size, ameliorate the variations in myocardial zymogram and histopathological disorders, decrease 20-HETE generation, and regulate apoptosis-related protein in myocardial ischemia-reperfusion rats[2]. |
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