| Identification | More | [Name]
5-(Aminomethyl)-2-chloropyridine | [CAS]
97004-04-1 | [Synonyms]
1-(6-CHLOROPYRIDIN-3-YL)METHANAMINE
2-CHLORO-5-AMINOMETHYLPYRIDINE
3-AMINOMETHYL-6-CHLORO PYRIDINE
5-AMINOMETHYL-2-CHLOROPYRIDINE
(6-CHLOROPYRIDIN-3-YL)METHYLAMINE
RARECHEM AL BW 0722
6-Chloro-3-Picolylamine
(6-CHLOROPYRIDIN-3-YL)METHANAMINE
6-CHLORO-3-PYRIDINEMETHYLAMINE
2-CHLORO-5-(AMINOMETHYL)PYRIDINE:1-(6-CHLOROPYRIDIN-3-YL)METHANAMINE
6-chloro-3-pyridinemethanamine | [EINECS(EC#)]
619-497-6 | [Molecular Formula]
C6H7ClN2 | [MDL Number]
MFCD00673153 | [Molecular Weight]
142.59 | [MOL File]
97004-04-1.mol |
| Chemical Properties | Back Directory | [Appearance]
White to Off-white crystal | [Melting point ]
28-34 °C | [Boiling point ]
101-102°C 1mm | [density ]
1.244±0.06 g/cm3(Predicted) | [Fp ]
>230 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil to Low-Melting Solid | [pka]
7.78±0.29(Predicted) | [color ]
Off-White to Light Brown | [Sensitive ]
Hygroscopic | [BRN ]
8308740 | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C6H7ClN2/c7-6-2-1-5(3-8)4-9-6/h1-2,4H,3,8H2 | [InChIKey]
XPARFBOWIYMLMY-UHFFFAOYSA-N | [SMILES]
C1=NC(Cl)=CC=C1CN | [CAS DataBase Reference]
97004-04-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T,C | [Risk Statements ]
R25:Toxic if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R43:May cause sensitization by skin contact.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S20:When using, do not eat or drink . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
2933399990 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-white crystal | [Uses]
5-Aminomethyl-2-chloropyridine is a reagent that is used in the synthesis of macamides and analogs that have FAAH (fatty acid amide hydrolase) inhibitory activity. | [Synthesis]
General procedure for the synthesis of 5-aminomethyl-2-chloropyridine from the compound (CAS:1080018-12-7) (Example 5): preparation of (2-chloropyridin-5-yl)methylamine (4). To 0.77 g (1.66 mmol) of 1,3,5-tris[(2-chloropyridin-5-yl)methyl]-1,3,5-perhydrotriazine (II-4) were sequentially added 0.40 g of methanol and 1.83 g of concentrated hydrochloric acid, and the resultant mixture was stirred for 6 hr. at 75 to 80° C. The reaction was carried out with the aid of a liquid chromatograph. After completion of the reaction, the reaction mixture was diluted with chloroform and adjusted to basicity by addition of 28% aqueous sodium hydroxide. The chloroform layer was separated and concentrated to give 0.68 g (yield: 95%) of the target product (2-chloropyridin-5-yl)methylamine (III-1). | [References]
[1] Patent: EP2141149, 2010, A1. Location in patent: Page/Page column 17
[2] Patent: US2010/121054, 2010, A1. Location in patent: Page/Page column 9 |
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