ChemicalBook--->CAS DataBase List--->99464-83-2

99464-83-2

Request For Quotation
99464-83-2 Structure

99464-83-2 Structure
IdentificationMore
[Name]

1-Chloroethyl cyclohexyl carbonate
[CAS]

99464-83-2
[Synonyms]

1-CHLOROETHYL CYCLOHEXYL CARBONATE
CARBONIC ACID 1-CHLOROETHYL CYCLOHEXYL ESTER
CYCLOHEXYL 1-CHLOROETHYLCARBONATE
1-chloroethylcyclohexyl carbonate (intermediate of candesartan cilexetil)
1-chloroethyl cyclohexyl carbonate (JCC-2)
ChloroethylCyclohexylCarbonate
[EINECS(EC#)]

444-950-8
[Molecular Formula]

C9H15ClO3
[MDL Number]

MFCD04038149
[Molecular Weight]

206.67
[MOL File]

99464-83-2.mol
Chemical PropertiesBack Directory
[Boiling point ]

283.9±19.0 °C(Predicted)
[density ]

1.13±0.1 g/cm3(Predicted)
[refractive index ]

1.4540-1.4580
[Fp ]

84 °C
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

Chloroform (Sparingly), Ethyl Acetate, Methanol (Slightly)
[form ]

Oil
[color ]

Colourless
[Stability:]

Hygroscopic
[InChI]

InChI=1S/C9H15ClO3/c1-7(10)12-9(11)13-8-5-3-2-4-6-8/h7-8H,2-6H2,1H3
[InChIKey]

ONZWFHWHTYZZLM-UHFFFAOYSA-N
[SMILES]

C(OC1CCCCC1)(=O)OC(Cl)C
[CAS DataBase Reference]

99464-83-2(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]

Corrosion (GHS05)
GHS05
[Signal word ]

Danger
[Hazard statements ]

H314
[Precautionary statements ]

P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[RIDADR ]

1760
[HS Code ]

2915.90.5010
[REACH Registrations]

Active
[HazardClass ]

8
[PackingGroup ]

II
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Cyclohexyl chloroformate-->Cyclohexanol-->Acetaldehyde-->1-Chloroethyl chloroformate-->Diphosgene-->Pyridine-->Paraldehyde-->Dichloromethane
[Preparation Products]

Trityl candesartan cilexetil
Hazard InformationBack Directory
[Chemical Properties]

Colorless or pale yellow liquid
[Uses]

1-Chloroethyl Cyclohexyl Carbonate is a genotoxic impurity used in the synthesis of Candesartan Cilexetil. an angiotensin II receptor antagonist.
[Synthesis]

1-chloroethyl chloroformate (1.99 g, 1.5 mL, 13.9 mmol) was reacted with cyclohexanol (1.33 g, 1.4 mL, 13.3 mmol) and pyridine (1.27 g, 1.3 mL, 16.1 mmol) in methylene chloride (11 mL) at ?78° C. for 3 h to give 1-chloroethyl cyclohexyl carbonate.
[References]

[1] Patent: US2008/125483, 2008, A1. Location in patent: Page/Page column 6-7
[2] Patent: WO2009/118580, 2009, A2. Location in patent: Page/Page column 17-18
[3] Patent: EP2526945, 2012, A1. Location in patent: Page/Page column 66
[4] Patent: WO2009/66917, 2009, A2. Location in patent: Page/Page column 17-18
[5] Patent: EP1477482, 2004, A1. Location in patent: Page 30
Spectrum DetailBack Directory
[Spectrum Detail]

1-Chloroethyl cyclohexyl carbonate(99464-83-2)1HNMR
Well-known Reagent Company Product InformationBack Directory
[TCI AMERICA]

1-Chloroethyl Cyclohexyl Carbonate,>98.0%(GC)(99464-83-2)
99464-83-2 suppliers list
Company Name: Anqing PhiChem Corporation  Gold
Telephone: 0556-5209970
Website: http://www.phichem.com.cn
Company Name: Nanjing Lirui Pharmaceutical Trading Co., Ltd.  Gold
Telephone: 15951922363
Website:
Company Name: Jiangsu laurel Pharma Co., Ltd  Gold
Telephone: 15861782979
Website: http://www.laurel-pharma.com
Company Name: J & K SCIENTIFIC LTD.  
Telephone: 18210857532 18210857532
Website: https://www.jkchemical.com
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
Telephone: 4006356688 18621169109
Website: www.x-labseek.com/
Company Name: TCI (Shanghai) Development Co., Ltd.  
Telephone: 021-67121386
Website: https://www.tcichemicals.com/CN/zh/
Company Name: Beijing dtftchem Technology Co., Ltd.  
Telephone: 010-60275820 13031183356
Website: www.dtfchem.com
Company Name: Energy Chemical  
Telephone: 400-0056266
Website: www.energy-chemical.com
Company Name: Capot Chemical Co., Ltd  
Telephone: +86 (0) 571 85 58 67 18
Website: www.capotchem.com
Company Name: Beijing Ouhe Technology Co., Ltd  
Telephone: 13552068683 13522913783
Website: www.ouhetech.cn/
Company Name: JinYan Chemicals(ShangHai) Co.,Ltd.  
Telephone: 13817811078
Website: www.jingyan-chemical.com
Company Name: Jia Xing Isenchem Co.,Ltd  
Telephone: 0573-85285100 18627885956
Website: https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm
Company Name: Adamas Reagent, Ltd.  
Telephone: 400-6009262 15618770481
Website: www.tansoole.com
Company Name: Shanghai Longsheng chemical Co.,Ltd.  
Telephone: 58099637 13585536065
Website: www.shlshg.com
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Telephone: 025-83697070 13770331960
Website: www.echemlin.cn
Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Telephone: 021-54306202 13764082696
Website: https://www.hanhongsci.com
Company Name: Syntechem Co.,Ltd  
Telephone:
Website: www.syntechem.com
Company Name: Sichuan Kulinan Technology Co., Ltd  
Telephone: 400-1166-196 18981987031
Website: http://www.hx-r.com/
Tags:99464-83-2 Related Product Information
96-49-1 3173-53-3 3486-35-9 497-19-8 105-58-8 872-36-6 616-38-6 35180-01-9 506-87-6 513-77-9 108-32-7 471-34-1 145040-37-5 98298-66-9 50893-36-2 99464-83-2