6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯

6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯性质、用途与生产工艺

生产方法 

110-85-0

113046-72-3

113028-17-4

以6,7-二氟-1-甲基-4-氧代-1,4-二氢-[1,3]硫氮杂丁环并[3,2-a]喹啉-3-羧酸乙酯和哌嗪为原料，合成6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯的一般步骤如下：将50g 6,7-二氟-1-甲基-4-氧代-4H-[1,3]噻嗪[3,2-a]喹啉-3-羧酸乙酯溶于5体积的DMSO中，加热至60℃。随后加入40g哌嗪，保持60℃搅拌反应4小时。反应完成后，将混合物冷却至室温，加入5体积的乙腈，继续在室温下搅拌4小时。过滤收集沉淀，干燥后得到52.8g 6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]噻唑环[3,2-a]喹啉-3-羧酸乙酯，收率为87%。进一步纯化后，6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]噻唑环[3,2-a]喹啉-3-羧酸乙酯的收率可达99%。

参考文献：

[1] Patent: CN107383069, 2017, A. Location in patent: Paragraph 0061; 0062

[2] Patent: CN107501298, 2017, A. Location in patent: Paragraph 0055; 0056

[3] Journal of Medicinal Chemistry, 1992, vol. 35, # 25, p. 4727 - 4738

[4] Patent: US4843070, 1989, A

[5] Patent: WO2009/93268, 2009, A1. Location in patent: Page/Page column 15

6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯 上下游产品信息

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6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯 生产厂家

113028-17-4, 6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯 相关搜索:

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