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Ivermectin Produkt Beschreibung

Ivermectin Struktur
70288-86-7
CAS-Nr.
70288-86-7
Bezeichnung:
Ivermectin
Englisch Name:
Ivermectin
Synonyma:
mk933;Vermic;Uvemec;IVOMEC;Ivosint;mk-0933;EQVALEN;Mectizan;CARDOMEC;Ivermecti
CBNumber:
CB0415655
Summenformel:
C48H74O14
Molgewicht:
875.09
MOL-Datei:
70288-86-7.mol

Ivermectin Eigenschaften

alpha 
D +71.5 ± 3° (c = 0.755 in chloroform)
RTECS-Nr.
IH7891500
storage temp. 
2-8°C
Löslichkeit
H2O: ≤1.0% KF
Aggregatzustand
powder
InChIKey
AZSNMRSAGSSBNP-XPNPUAGNSA-N
CAS Datenbank
70288-86-7(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,Xn,T+
R-Sätze: 61-25-36-36/38-22-28
S-Sätze: 53-26-45-36-36/37-28
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
HazardClass  6.1(a)
PackingGroup  II
HS Code  29322090
Toxizität LD50 in dogs, rhesus monkeys (mg/kg): about 80, more than 24 orally. (MSDS Merck & Co. Inc., 2003)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P281 Vorgeschriebene persönliche Schutzausrüstung verwenden.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.

Ivermectin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R61:Kann das Kind im Mutterleib schädigen.
R25:Giftig beim Verschlucken.
R36:Reizt die Augen.
R36/38:Reizt die Augen und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Ivermectin is an antiparasitic agent effective in the treatment of onchocerciasis, or "river blindness". Since ivermectin acts to prevent the adult worm from producing microfilariae, it needs to be administered only once or twice a year.

Chemische Eigenschaften

Crystalline Solid

Originator

Merck (USA)

Verwenden

Semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Antihelmintic (Onchocerca)

Verwenden

beta-lactamase inhibitor; antibiotic

Verwenden

antiparasitic

Verwenden

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Indications

Ivermectin (Mectizan) acts on parasite-specific inhibitory glutamate-gated chloride channels that are phylogenetically related to vertebrate GABA-gated chloride channels. Ivermectin causes hyperpolarization of the parasite cell membrane and muscle paralysis.At higher doses it can potentiate GABA-gated chloride channels. It does not cross the blood-brain barrier and therefore has no paralytic action in mammals, since GABA-regulated transmission occurs only in the central nervous system (CNS). Ivermectin is administered by the oral and subcutaneous routes. It is rapidly absorbed. Most of the drug is excreted unaltered in the feces. The half-life is approximately 12 hours.

Trademarks

Stromectol (Merck);Mectizan.

Antimicrobial activity

It is also active against O. volvulus and other filarial worms, but the effect is chiefly directed against the larval forms (microfilariae). Uniquely among anthelmintic agents it exhibits activity against some ectoparasites, including Sarcoptes scabiei.

Pharmazeutische Anwendungen

A mixture of two closely related semisynthetic derivatives of avermectins, a complex of macrocyclic lactone antibiotics produced by Streptomyces avermitilis. In commercial preparations the ratio of the two components, dihydroavermectin B1a and dihydroavermectin B1b, are present within the limits 80–90% and 10–20%, respectively.

Biologische Aktivität

Positive allosteric modulator of the α 7 neuronal nicotinic acetylcholine receptor and the purinergic P2X 4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).

Pharmakokinetik

Oral absorption: c. 60%
Cmax 12 mg oral: c. 30–47 ng/mL after 4 h
Plasma half-life: c. 12 h
Volume of distribution: 46.9 L
Plasma protein binding: 93%
It is rapidly metabolized in the liver and the metabolites are excreted in the feces over about 12 days with minimal (<1%) urinary excretion. Highest concentrations occur in the liver and fat. Extremely small amounts are found in the brain.

Clinical Use

Ivermectin (Cardomec, Eqvalan, Ivomec) is a mixtureof 22,23-dihydro derivatives of avermectins B1a and B1bprepared by catalytic hydrogenation. Avermectins aremembers of a family of structurally complex antibioticsproduced by fermentation with a strain of Streptomycesavermitilis. Their discovery resulted from an intensivescreening of cultures for anthelmintic agents from naturalsources. Ivermectin is active in low dosage against awide variety of nematodes and arthropods that parasitizeanimals.
Ivermectin has achieved widespread use in veterinarypractice in the United States and many countries throughoutthe world for the control of endoparasites and ectoparasitesin domestic animals. It has been found effective forthe treatment of onchocerciasis (“river blindness”) in humans, an important disease caused by the roundwormOncocerca volvulus, prevalent in West and Central Africa,the Middle East, and South and Central America.Ivermectin destroys the microfilariae, immature forms ofthe nematode, which create the skin and tissue nodules thatare characteristic of the infestation and can lead to blindness.It also inhibits the release of microfilariae by theadult worms living in the host. Studies on the mechanismof action of ivermectin indicate that it blocks interneuron–motor neuron transmission in nematodes by stimulatingthe release of the inhibitory neurotransmitter GABA.The drug has been made available by the manufacturer ona humanitarian basis to qualified treatment programsthrough the World Health Organization.

Clinical Use

Onchocerciasis
Non-disseminated strongyloidiasis
Lymphatic filariasis (in combination with albendazole)
Scabies
If the patient is harboring Asc. lumbricoides, the worms will be passed in the feces. Head lice will also be killed, which is very much welcomed by the treated patients. Ivermectin has been widely used in the veterinary field, where use is also made of its effect on ectoparasites.

Clinical Use

Ivermectin has broad-spectrum activity in that it can affect nematodes, insects, and acarine parasites. It is the drug of choice in onchocerciasis and is quite useful in the treatment of other forms of filariasis, strongyloidiasis, ascariasis, loiasis, and cutaneous larva migrans. It is also highly active against various mites. It is the drug of choice in treating humans infected with Onchocerca volvulus, acting as a microfilaricidal drug against the skin-dwelling larvae (microfilaria). Annual treatment can prevent blindness from ocular onchocerciasis. Ivermectin is clearly more effective than diethylcarbamazine in bancroftian filariasis, and it reduces microfilaremia to near zero levels. In brugian filariasis diethylcarbamazine- induced clearance may be superior. It also is used to treat cutaneous larva migrans and disseminated strongyloidiasis. Its safe use in pregnancy has not been fully established.

Nebenwirkungen

The side effects are minimal, with pruritus, fever, and tender lymph nodes occasionally seen. The side effects are considerably less than those associated with diethylcarbamazine administration.

Nebenwirkungen

In the treatment of onchocerciasis mild Mazzotti-type reactions occur, with occasional neurological problems. Although it is highly effective against L. loa, care must be taken to avoid treating patients with high microfilarial counts: there is one report of a patient with a concomitant L. loa infection who died when treated for onchocerciasis. Mild gastrointestinal and nervous system signs may occur following treatment for strongyloidiasis.

Veterinary Drugs and Treatments

Ivermectin is approved in horses for the control of: large strongyles (adult) (Strongylus vulgaris, S. edentatus, S. equinus, Triodontophorus spp.), small strongyles, pinworms (adults and 4th stage larva), ascarids (adults), hairworms (adults), large-mouth stomach worms (adults), neck threadworms (microfilaria), bots (oral and gastric stages), lungworms (adults and 4th stage larva), intestinal threadworms (adults), and summer sores (cutaneous 3rd stage larva) secondary to Hebronema or Draschia Spp.
In cattle, ivermectin is approved for use in the control of gastrointestinal roundworms (adults and 4th stage larva), lungworms (adults and 4th stage larva), cattle grubs (parasitic stages), sucking lice, and mites (scabies). For a listing of individual species covered, refer to the product information.
In swine, ivermectin is approved for use to treat GI roundworms, lungworms, lice, and mange mites. For a listing of individual species covered, refer to the product information.
In reindeer, ivermectin is approved for use in the control of warbles.
In American Bison, ivermectin is approved for use in the control of grubs.
In dogs and cats, ivermectin is approved only for use as a preventative for heartworm. It has also been used as a microfilaricide, slow-kill adulticide, ectoparasiticide, and endoparasiticide.

Ivermectin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ivermectin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 358)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3202 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21753 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 661 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 535 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1849 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 27142 58
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 302 58

70288-86-7(Ivermectin)Verwandte Suche:


  • Lvermectin1
  • IVERMECTINE(PATENT-NOSUPPLY)
  • 22,23-Dihydro C-076B1
  • Ivosint
  • Mectizan
  • Stromectol
  • Uvemec
  • Vermic
  • Zimecterin
  • 22,23-Dihydroavermectin B1, MK-933
  • Ivermectin (EDMF)
  • Ivermecti
  • 22,23-Dihydro C-076 Bla
  • 22,23-Dihydro C-176B
  • 22,23-Dihydroabamectin
  • 22,23-Dihydroavermectin Bla
  • 22,23-Dihydroavermectin Blb
  • 5-O-Demethyl-22,23-dihydmavermectin Ala
  • Cardotek-30:Eqvalan
  • hyvermectin
  • mk-0933
  • Ivermectin, >=98%
  • VERMECTIN
  • Ivermectin 70288-86-7
  • Ivermectin, 98.5%
  • High purity Ivermectin 99% in stock CAS NO.70288-86-7 CAS NO.70288-86-7
  • mk933
  • 22,23-DIHYDROAVERMECTIN B1
  • 22,23-DIHYDROAVERMECTINE
  • 22,23-Dihydroavemectin B1
  • Ivermectin,22,23-Dihydroavermectin B1, MK-933
  • Ivermectin (200 mg)
  • Ivermectin (200 mg)G0D4080.906mg/mg(ai)
  • IverMectin(FDA)
  • IverMectin, USP
  • (1'R,2R,4'S,5S,6R,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-Methoxy-6-Methyloxan-2-yl]oxy}-4-Methoxy-6-Methyloxan-2-yl]oxy}-5,11',13',22'-tetraMethyl-6-(propan-2-yl)-3',7',19'-trioxasp
  • IverMectin COS
  • IvetMectin
  • Ivermectine 0
  • Avermectin B1a Dihydro Analog
  • IVOMEC
  • IVERMECTIN
  • IVERMECTINE
  • heartgard-30
  • EQVALEN
  • CARDOMEC
  • IVERMECTIN HCL
  • Ivermectin EP2000
  • IVERMECTIN NOT LESS THAN 93.0% OF 22,23-DIHY- DROAVERMECTIN B1A, AND NOT LESS THAN 97.0% OF 22,23-DIHY-DROAVERMECTIN B1(B1A+B1B)
  • IVERMECTIN EP(CRM STANDARD)
  • IVERMECTIN USP(CRM STANDARD)
  • IvermectineEp2000
  • 70288-86-7
  • 7028-86-7
  • C48H74O14
  • C48H74O14C47H72O14
  • C47H71O14R
  • C48H74O14B1aform
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