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Nystatin Produkt Beschreibung

Nystatin Struktur
1400-61-9
CAS-Nr.
1400-61-9
Bezeichnung:
Nystatin
Englisch Name:
Nystatin
Synonyma:
nystan;Nystex;Nystop;MORONAL;nilstat;Nyotran;Nystain;NYSTATIN;biofanal;stamycin
CBNumber:
CB0463474
Summenformel:
C47H75NO17
Molgewicht:
926.09
MOL-Datei:
1400-61-9.mol

Nystatin Eigenschaften

Schmelzpunkt:
>155°C (dec.)
alpha 
D25 -10° (glacial acetic acid); +21° (pyridine); +12° (DMF); -7° (0.1N HCl in methanol)
storage temp. 
−20°C
Löslichkeit
H2O: insoluble
Aggregatzustand
suspension
pka
pKa 5.72(MeOH/2-methoxyethanol/ H2O) (Uncertain);8.64 (Uncertain)
Farbe
yellow
Merck 
13,6770
InChIKey
VXWFKTGGEJLHPP-OQMKPJEFSA-N
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher F,C
R-Sätze: 11-34
S-Sätze: 22-24/25-45-36/37/39-26-16
WGK Germany  3
RTECS-Nr. RF5950000
10-8-23
HazardClass  3
HS Code  38210000
Giftige Stoffe Daten 1400-61-9(Hazardous Substances Data)
Toxizität LD50 i.p. in mice: ~200 mg/kg (Seneca)
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H311 Giftig bei Hautkontakt. Akute Toxizität dermal Kategorie 3 Achtung P280, P302+P352, P312, P322, P361,P363, P405, P501
H331 Giftig bei Einatmen. Akute Toxizität inhalativ Kategorie 3 Achtung P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H370 Schädigt die Organe. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 1 Achtung P260, P264, P270, P307+P311, P321,P405, P501
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P303+P361+P353 BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.
P405 Unter Verschluss aufbewahren.

Nystatin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R11:Leichtentzündlich.
R34:Verursacht Verätzungen.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

Brown Solid

Verwenden

Antifungal;Performs membrane ionophores

Verwenden

Nystatin is polyene antifungal containing a conjugated tetraene and a diene, isolated as a complex of three components A1, A2 and A3 from Streptomyces noursei and first reported in 1950. Nystatin, like most polyene antifungals, binds to sterols in the fungal cell membrane leading to formation of ion channels in the wall, ion imbalance and cell death. Nystatin is an established bioprobe and widely-used antifungal reagent with over 4,000 literature citations.

Verwenden

Polyene antifungal antibiotic complex containing 3 biologically active components, A1, A2, A3. Increases the permeability of the cell membrane of sensitive fungi by binding to sterols. Cell culture tested. Growth promotant. Nystatin A1 is shown.

Definition

ChEBI: A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptococcus species. The keto-form of nystatin A1.

Indications

Nystatin (Mycostatin) is a polyene antifungal drug with a ring structure similar to that of amphotericin B and a mechanism of action identical to that of amphotericin B. Too toxic for systemic use, nystatin is limited to the topical treatment of superficial infections caused by C. albicans. Infections commonly treated by this drug include oral candidiasis (thrush), mild esophageal candidiasis, and vaginitis.

Trademarks

Barstatin 100 (Barlan); Candex (Bayer); Korostatin (Holland Rantos); Mycostatin (Bristol-Myers Squibb); Mycostatin (Westwood-Squibb).

Allgemeine Beschreibung

Nystatin (Mycostatin) is a polyene antibiotic that was first isolated in 1951 from a strain of the actinomycete Streptomyces noursei by Hazen and Brown.33 It occurs as a yellow to light tan powder. Nystatin is very slightly soluble in water and sparingly soluble in organic solvents. The compound is unstable to moisture, heat, and light. The aglycone portion of nystatin is called nystatinolide. The complete structure of nystatin has been determined by chemical degradation and x-ray crystallography.35 Nystatin is not absorbed systemically when administered by the oral route. It is nearly insoluble under all conditions. It is also too toxic to be administered parenterally. Hence, it is used only as a topical agent. Nystatin is a valuable agent for the treatment of local and gastrointestinal monilial infections caused by C. albicans and other Candida species. For the treatment of cutaneous and mucocutaneous candidiasis, it is supplied as a cream, an ointment, and a powder. Vaginal tablets are available for the control of vaginal candidiasis. Oral tablets and troches are used in the treatment of gastrointestinal and oral candidiasis. Combinations of nystatin with tetracycline can be used to prevent monilial overgrowth caused by the destruction of bacterial microflora of the intestine during tetracycline therapy.

Sicherheitsprofil

Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. An experimental teratogen. Mutation data reported. An antibiotic. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Orally administered nystatin is used primarily for the treatment of oral or gastrointestinal tract Candida infections in dogs, cats, and birds; it has been used less commonly in other species for the same indications.

läuterung methode

Nystatin is a light yellow powder with the following solubilities at ~28o: MeOH (1.1%), ethylene glycol (0.9%), H2O (0.4%), CCl4 (0.12%), EtOH (0.12%), CHCl3 (0.05%) and *C6H6 (0.03%). It has been precipitated from MeOH solution by addition of H2O. Aqueous suspensions of this macrolide antifungal antibiotic are stable at 100o/10minutes at pH 7.0 but decompose rapidly at pH <2 and >9, and in the presence of light and O2. [Birch et al. Tetrahedron Lett 1491, 1485 1964, Weiss et al. Antibiot Chemother 7 374 1957.] It may contain a mixture of components A1, A2 and A3. [Beilstein 18 III/IV 7480.]

Nystatin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Nystatin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 263)Lieferanten
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02783214688 bruce@xrdchem.cn CHINA 535 55
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Hubei Jusheng Technology Co.,Ltd.
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QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58

1400-61-9(Nystatin)Verwandte Suche:


  • Nystatin (Fungicidin)
  • Polyfungin A1
  • Nystatin Min. 4 400 units/Mg research grade
  • EZNA KIT SOIL DNA
  • Nystatin, Antibiotic for Culture Media Use Only
  • NystatinUSP, ≥ 4400 u/mg (Potency anhydrous)
  • MORONAL
  • MYCOSTATIN
  • MYCOSTATIN(R)
  • NYSTATIN, STREPTOMYCES NOURSEI
  • NYSFUNGIN
  • NYSTATIN
  • biofanal
  • candio-hermal
  • candio-hermal[qr]
  • Ceratocide
  • diastatin
  • diastatin[qr]
  • fungiciden[qr]
  • fungicidin[qr]
  • korostatin[qr]
  • moronal[antibiotic][qr]
  • moronal[qr]
  • myconystatin[qr]
  • mycostatin[qr]
  • mycostatin20
  • mycostatin20[qr]
  • mykostatyna[qr]
  • nilstat
  • nilstat[qr]
  • nistatin[qr]
  • nystan
  • nystan[qr]
  • nystatin(streotomycesnoursei)
  • nystatin(streotomycesnoursei)(withdrawn:23614-r:pm24)
  • nystatine
  • nystatine[qr]
  • nystatyna
  • nystavescent
  • nystavescent[qr]
  • o-vstatin
  • NYSTATIN GAMMA-IRRADIATED CELL CULTURE T ESTED
  • NYSTATIN WHO(CRM STANDARD)
  • NYSTATIN USP(CRM STANDARD)
  • NYSTATIN CELL CULTURE REAGENT
  • NYSTATIN EPN(CRM STANDARD)
  • Nystatin min. 4 400 units/mg
  • nystatin preparation
  • NYSTATIN,POWDER,USP
  • L-Nystatin
  • Moronal (antibiotic)
  • Myconystatin
  • Mycostatin Pastilles
  • Mykostatyna
  • Nyotran
  • Nystatin (8CI, 9CI)
  • Nystex
  • Nystop
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