3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphin-2,18-diyl)di(propionsure)

Protoporphyrin IX Struktur
553-12-8
CAS-Nr.
553-12-8
Bezeichnung:
3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphin-2,18-diyl)di(propionsure)
Englisch Name:
Protoporphyrin IX
Synonyma:
PPIX;PROTOPORPHYRIN;ZINC PROTOPORPHYRIN;ZINC PROTOPORPHYRIN-9;ZINC PROTOPORPHYRIN IX;2,18-Porphinedipropionic acid, 3,8,13,17-tetramethyl-7,12-divinyl-;ZNPP-9;185646;OOPORPHYRIN;PROTOPORPHYRIN-9
CBNumber:
CB0723565
Summenformel:
C34H34N4O4
Molgewicht:
562.66
MOL-Datei:
553-12-8.mol

3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphin-2,18-diyl)di(propionsure) Eigenschaften

Schmelzpunkt:
>300 °C(Solv: acetone (67-64-1))
Siedepunkt:
629.06°C (rough estimate)
Dichte
1.1829 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
2-8°C
Löslichkeit
DMSO (Slightly)
Aggregatzustand
Powder
Farbe
purple
Wasserlöslichkeit
106.9mg/L(25 ºC)
Sensitive 
light sensitive
Merck 
13,7990
BRN 
380795
Stabilität:
Light Sensitive
InChIKey
FEDYMSUPMFCVOD-UJJXFSCMSA-N
CAS Datenbank
553-12-8
NIST chemische Informationen
Protoporphyrin-1x(553-12-8)
EPA chemische Informationen
Protoporphyrin IX (553-12-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36
WGK Germany  3
8-10-23
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphin-2,18-diyl)di(propionsure) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Verwenden

Protoporphyrin IX has been used:
  • as a standard in protoporphyrin assays
  • in fluorescence spectra analysis
  • to treat cells in cell culture to study heme-mediated ferroportin 1 transcription

Definition

ChEBI: A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyri s.

Allgemeine Beschreibung

Protoporphyrin IX belongs to the porphyrin family, which are a class of tetrapyrroles. It is the iron-free form of hemin and amphiphilic in nature. It is the precursor of heme in its biosynthetic pathway.

Enzyminhibitor

This iiron-free, immediate precusor of heme (FWfree-acid = 562.67 g/mol; CAS 553-12-8; brownish-yellow solid; soluble in a number of organic solvents; disodium and dipotassium salts solublized in the presence of Tween 80) has lmax values in 25% HCl are 602.4, 582.2, and 557.2 nm. Protoporphryrin IX is also an activator of guanylate cyclase. See also Iron Protoporphyrin IX; Heme; Hemin Target(s): aminolevulinate aminotransferase; 5-aminolevulinate synthase; glutamate: glyoxylate aminotransferase; glutathione S-transferase; glyoxalase I, or lactoylglutathione lyase; guanylate cyclase; heme oxygenase; hydroxymethylbilane synthase, or porphobilinogen deaminase; nitric-oxide synthase; porphobilinogen synthase, or 5-aminolevulinate dehydratase; succinyl-CoA synthetase; tryptophan pyrrolase, or tryptophan 2,3-dioxygenase; and uroporphyrinogen decarboxylase.

läuterung methode

Protoporphyrin IX (3,18-divinyl-2,7,13,17-tetramethylporphin-8,12-dipropionic acid, ooporphyrin) [553-12-8] M 562.7, pKEst ~ 4.8. Protoporphyrin IX is purified by dissolving (4g) in 98-100% HCOOH (85mL), diluting with dry Et2O (700mL) and keeping at 0o overnight. The precipitate is collected and washed with Et2O, then H2O, and dried in a vacuum at 50o over P2O5. It crystallises from aqueous pyridine and from Et2O in monoclinic, brownish-yellow prisms. The UV max values in 25% HCl are 557.2, 582.2 and 602.4nm. It is freely soluble in ethanolic HCl, AcOH, CHCl3, and Et2O containing AcOH. It forms sparingly soluble diNa and diK salts. [Ramsey Biochemical Preparations 3 39 1953, UV: Holden Aust J. Exptl Biol and Med Sci 15 412 1937, Garnick J Biol Chem 175 333 1948, IR: Falk & Willis Aust J Sci Res [A] 4 579 1951, Beilstein 26 IV 3042.]

3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphin-2,18-diyl)di(propionsure) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphin-2,18-diyl)di(propionsure) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 204)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5990 58
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075
jack.li@time-chemicals.com China 1807 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3012 60
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569265 +86-18612256290
1056@dideu.com China 3959 58
Chengdu Aslee Biopharmaceuticals, Inc.
28-85305008
CHINA 964 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
sales@tnjchem.com China 34572 58

553-12-8(3,3'-(3,7,12,17-Tetramethyl-8,13-divinylporphin-2,18-diyl)di(propionsure))Verwandte Suche:


  • KAMMERER'S PORPHYRIN
  • 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-
  • 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid
  • Kammerer's prophyrin
  • PROTOPORPHYRIN-'IX', FOR FLUORESCENCE
  • ProtoporphyrinIXforfluorescence95+%
  • PROTOPORPHYRINIX,FREEACID
  • Kammerers porphyrin, Ooporphyrin, 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid
  • 18-porphinedipropionic acid
  • 3,7,12,17-Tetramethyl-8,13-divinyl-2
  • 3,3-(3,7,12,17-tetramethyl-8,13-divinylporphine-2,18-diyl)di(propionic acid)
  • ProtoporphyrinIXpurplepowder
  • OOPORPHYRIN
  • PROTOPORPHYRIN-9
  • PROTOPORPHYRIN IX ZINC (II)
  • PROTOPORPHYRIN IX ZINC(II) COMPLEX
  • PROTOPORPHYRIN IX
  • PROTOPORPHYRIN-'IX'
  • (SP-4-2)-[7,12-DIETHENYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPANOATO(4-)-N21,N22,N23,N24]-DIHYDROGEN ZINCATE(2-)
  • ZNPP-9
  • ZN(II) PROTOPORPHYRIN IX
  • ZINC(II) PROTOPORPHYRIN IX
  • 3,18-DIVINYL-2,7,13,17-TETRAMETHYLPORPHINE-8, 12-DIPROPIONIC ACID
  • 3,7,12,17-TETRAMETHYL-8,13-DIVINYL-2,18-PORPHINE-DIPROPIONIC ACID
  • 8,13-DIVINYL-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID ZINC DERIVATIVE
  • 8,13-DIVINYL-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID
  • 8,13-BIS(VINYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID
  • 8,13-BIS(VINYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID ZINC(II)
  • 7,12-DIETHENYL-3,8,13,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID, ZINC COMPLEX
  • Protoporphyrin IX, ≥95%
  • 3,3'-(3,8,13,17-tetramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionic acid
  • 185646
  • Protoporphyrin IX USP/EP/BP
  • 3,3'-(3,8,13,17-Ttramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionic acid
  • 2,18-Porphinedipropionic acid, 3,8,13,17-tetramethyl-7,12-divinyl-
  • PROTOPORPHYRIN
  • ZINC PROTOPORPHYRIN-9
  • ZINC PROTOPORPHYRIN
  • ZINC PROTOPORPHYRIN IX
  • PPIX
  • rotoporphyrin IX
  • 2H6]-Protoporphyrin IX
  • Protoporphyrin IX (6CI)
  • 553-12-8
  • 15442-64-3
  • C34H34N4O4
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Biochemicals and Reagents
  • BioChemical
  • Cyclic Nucleotide Metabolism
  • Detection
  • G Proteins and Cyclic Nucleotides
  • Guanylyl Cyclase Activators
  • Fluorescent Probes, Labels, Particles and Stains
  • Inhibitors
  • Natural Porphyrins and Derivitives
  • Porphyrins
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