ChemicalBook
Chinese english Germany Japanese Korea

Allopurinol Produkt Beschreibung

Allopurinol Struktur
315-30-0
CAS-Nr.
315-30-0
Bezeichnung:
Allopurinol
Englisch Name:
Allopurinol
Synonyma:
HPP;ALO;4-HPP;Remid;Urbol;Pural;AL-100;aloral;Anzief;Apurin
CBNumber:
CB1181254
Summenformel:
C5H4N4O
Molgewicht:
136.11
MOL-Datei:
315-30-0.mol

Allopurinol Eigenschaften

Schmelzpunkt:
>300 °C(lit.)
Siedepunkt:
250.36°C (rough estimate)
Dichte
1.4295 (rough estimate)
Brechungsindex
1.8500 (estimate)
storage temp. 
Room temperature.
Löslichkeit
1 M NaOH: soluble50mg/mL, clear to very slightly hazy, colorless to faintly yellow
pka
10.2(at 25℃)
Aggregatzustand
Powder
Farbe
White or almost white
Wasserlöslichkeit
0.35 g/L (25 ºC)
Merck 
14,279
InChIKey
OFCNXPDARWKPPY-UHFFFAOYSA-N
CAS Datenbank
315-30-0(CAS DataBase Reference)
NIST chemische Informationen
Allopurinol(315-30-0)
EPA chemische Informationen
Allopurinol (315-30-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,Xi,Xn
R-Sätze: 25-43-36/37/38-20/21/22
S-Sätze: 28-36/37-45-36/37/39-26-24-36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  2
RTECS-Nr. UR0785000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29335990
Giftige Stoffe Daten 315-30-0(Hazardous Substances Data)
Toxizität LD50 oral in mouse: 78mg/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P272 Kontaminierte Arbeitskleidung nicht außerhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P321 Besondere Behandlung
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Allopurinol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R43:Sensibilisierung durch Hautkontakt möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24:Berührung mit der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic

Verwenden

antihyperuricemia, antigout, antiurolithic

Indications

Allopurinol (Zyloprim) is the drug of choice in the treatment of chronic tophaceous gout and is especially useful in patients whose treatment is complicated by renal insufficiency.

Trademarks

Lopurin (Abbott); Lopurin (BASF); Zyloprim (Promethus).

Allgemeine Beschreibung

Odorless tasteless white microcrystalline powder.

Air & Water Reaktionen

Insoluble in water.

Reaktivität anzeigen

Allopurinol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Allopurinol darkens above 572° F, and at an indefinite high temperature, Allopurinol chars and decomposes. At 221° F, maximum stability occurs at pH 3.1- 3.4. Allopurinol decomposes in acidic and basic solutions.

Brandgefahr

Flash point data for Allopurinol are not available; however, Allopurinol is probably combustible.

Mechanism of action

Allopurinol, in contrast to the uricosuric drugs, reduces serum urate levels through a competitive inhibition of uric acid synthesis rather than by impairing renal urate reabsorption. This action is accomplished by inhibiting xanthine oxidase, the enzyme involved in the metabolism of hypoxanthine and xanthine to uric acid. After enzyme inhibition, the urinary and blood concentrations of uric acid are greatly reduced and there is a simultaneous increase in the excretion of the more soluble uric acid precursors, xanthine and hypoxanthine.
Allopurinol itself is metabolized by xanthine oxidase to form the active metabolite oxypurinol, which tends to accumulate after chronic administration of the parent drug.This phenomenon contributes to the therapeutic effectiveness of allopurinol in long-term use. Oxypurinol is probably responsible for the antigout effects of allopurinol. Oxypurinol itself is not administered because it is not well absorbed orally.

Clinical Use

Allopurinol is especially indicated in the treatment of chronic tophaceous gout, since patients receiving it show a pronounced decrease in their serum and urinary uric acid levels. Because it does not depend on renal mechanisms for its efficacy, allopurinol is particularly beneficial for patients who already have developed renal uric acid stones, patients with excessively high urate excretion (e.g., above 1,200 mg in 24 hours), patients with a variety of blood disorders (e.g., leukemia, polycythemia vera), patients with excessive tophus deposition, and patients who fail to respond well to the uricosuric drugs.
Allopurinol also inhibits reperfusion injury. This injury occurs when organs that either have been transplanted or have had their usual blood perfusion blocked are reperfused with blood or an appropriate buffer solution. The cause of this injury is local formation of free radicals, such as the superoxide anion, the hydroxyl free radical, or peroxynitrite. These substances are strong oxidants and are quite damaging to tissues.

Nebenwirkungen

Common toxicities associated with allopurinol administration include a variety of skin rashes, gastrointestinal upset, hepatotoxicity, and fever. These reactions are often sufficiently severe to dictate termination of drug therapy. It is advised that therapy not be initiated during an acute attack of gouty arthritis. As with the uricosuric drugs, therapy with allopurinol should be accompanied both by a sufficient increase in fluid intake to ensure water diuresis and by alkalinization of the urine. Prophylactic use of colchicine also helps to prevent acute attacks of gout that may be brought on during the initial period of allopurinol ingestion.

Sicherheitsprofil

Human poison by ingestion. Poison experimentally by intraperitoneal and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: blood leukopenia, dermatitis, jaundice, muscle weakness, thrombocytopenia. When heated to decomposition it emits toxic fumes of NOx. An FDA proprietary drug used as a xanthine oxidase inhibitor.

Veterinary Drugs and Treatments

The principle veterinary uses for allopurinol are for the prophylactic treatment of recurrent uric acid uroliths and hyperuricosuric calcium oxalate uroliths in small animals. It has also been used in an attempt to treat gout in pet birds and reptiles.
Allopurinol has been recommended as an alternative treatment for canine Leishmaniasis. Although it appears to have clinical efficacy, it does not apparently clear the parasite in most dogs at usual dosages. Allopurinol may also be useful for American Trypanosomiasis.

Vorsichtsmaßnahmen

Since allopurinol is metabolized by the hepatic microsomaldrug-metabolizing enzymes, coadministration ofdrugs also metabolized by this system should be donewith caution. Because allopurinol inhibits the oxidationof mercaptopurine and azathioprine, their individualadministered doses must be decreased by as much as75% when they are given together with allopurinol.Allopurinol may also increase the toxicity of other cytotoxicdrugs (e.g., vidarabine). The actions of allopurinolare not antagonized by the coadministration of salicylates.

Allopurinol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Allopurinol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 419)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86-571-85586718
+86-571-85864795 sales@capotchem.com China 19920 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Anhui Royal Chemical Co., Ltd.
+86-025-86736275
dana.jiang@royal-chem.com CHINA 511 55
Hebei Minshang Biotechnology Co., Ltd
+86-13582176207
cathy@hbminshang.com CHINA 285 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30057 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28235 58

315-30-0(Allopurinol)Verwandte Suche:


  • Hydroxypyrazolodpyrimidine
  • pyrazolo(3,4-d)pyrimidin-1-ol
  • AllopurinolBp2001
  • 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro- (7CI,8CI,9CI)
  • ALLOPURINOL, PHARMA
  • 4-Oxopyrazolo[3,4-d]pyrimidine
  • NSC 101655
  • ALLOPURINOL,USP
  • 1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE(ALLOPURINOL)
  • ALLOPURINOL(P)
  • ALLOPURINOL(RG)
  • 4-HYDROXYPYROZOLO(3,4-D)PYRIMIDINE
  • ALLOPURIONAL
  • 4-HYDROXYPYRAZOLO(3,4-D)-PYRIMIDINE (ALLOPURINOL)
  • 4-Hydroxypyrazolo3,4-dü-pyrimidine, 98%
  • 1H-Pyrazolo(3,4-d)pyrimidin-4-ol, 4-Hydroxypyrazolo(3,4-d)pyrimidine, 4-Hydroxypyrazolo[3,4-d]pyrimidine, HPP
  • Allopurinol - EP grade
  • Allopurinol Manufacturer
  • Don't Piao alcohol
  • Allopurinol 0
  • 4-Hydroxy-1H-pyrazolo[3,4-d]pyrimidine,98%
  • Allopurinol (1H-Pyrazolo(3,4-d)pyrimidin-4-ol)
  • ALLOPURINOL EP [DRUG AND DRUGS INTERMEDI
  • TIMTEC-BB SBB004202
  • ISOPURINOL
  • LABOTEST-BB LT00244764
  • HPP
  • 1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-OL
  • AKOS BBS-00005290
  • ALLPURINOL
  • AKOS BBS-00002073
  • 4-HYDROXYPYRAZOLE[3,4-D]PYRIMIDINE
  • 4-HYDROXYPYRAZOLEO[3,4-D]PYRIMIDINE
  • 4-HYDROXYPYRAZOLO[3,4-D]PYRIMIDINE
  • 4-HYDROXYPYRAZOLO(3,4-OL)-PYRIMIDINE
  • 1,5-Dihydro-4H-pyrazolo(3,4-d)pyrimidin-4-one
  • 1,5-dihydro-4h-pyrazolo(3,4-d)pyrimidine-4-one
  • 4’-hydroxypyrazolol(3,4-d)pyrimidine
  • 4-d)pyrimidin-4-one,1,5-dihydro-4h-pyrazolo(
  • 4-d]pyrimidin-4-one,1,5-dihydro-4h-pyrazolo[
  • 4-HPP
  • 4H-Pyrazolo(3,4-d)pyrimidin-4-one
  • 4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-
  • 4-hydroxy-1h-pyrazolo(3,4-d)pyrimidine
  • 4-Hydroxy-1H-pyrazolo[3,4-d]pyrimidine
  • 4-Hydroxy-3,4-pyrazolopyrimidine
  • 4'-Hydroxypyrazolol(3,4-d)pyrimidine
  • 4-Hydroxypyrazolopyrimidine
  • 4-Hydroxypyrazolyl(3,4-d)pyrimidine
  • Adenock
  • Ailural
  • AL-100
  • Allopur
  • allo-puren
  • Allopurinol(I)
  • Allozym
  • Allural
  • aloral
Copyright 2019 © ChemicalBook. All rights reserved