ChemicalBook Deutsch Chinese English Japanese Korea
ChemicalBook > Produktkatalog >Aktive pharmazeutische Wirkstoffe (APIs) >Nervensystem Drogen >Antipsychotika >Chlorpromazin-hydrochlorid

Chlorpromazin-hydrochlorid Produkt Beschreibung

CAS-Nr.69-09-0
Bezeichnung:Chlorpromazin-hydrochlorid
Englisch Name:Chlorpromazine hydrochloride
Synonyma:
HEBANIL;promacid;promapar;sonazine;taroctyl;LARGACTIL;neurazine;norcozine;propaphen;KLORPROMEX
CBNumber:CB1492923
Summenformel:C17H20Cl2N2S
Molgewicht:355.33
MOL-Datei:69-09-0.mol
Chlorpromazin-hydrochlorid physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 192-196°C
Dichte: 1.2221 (estimate)
Flammpunkt:: 9℃
storage temp. : -20°C Freezer
Löslichkeit: Very soluble in water, freely soluble in ethanol (96 per cent). It decomposes on exposure to air and light.
Aggregatzustand: Powder/Solution
Farbe: White to off-white or clear colorless
PH: pH (50g/L, 25℃) : 4.0~5.0
Wasserlöslichkeit: >=10 g/100 mL at 24 ºC
Merck : 14,2185
BRN : 3779989
Stabilität:: Stable. Combustible. Incompatible with strong oxidizing agents. Air and light sesnsitive.
CAS Datenbank: 69-09-0(CAS DataBase Reference)
EPA chemische Informationen: 10H-Phenothiazine- 10-propanamine, 2-chloro-N,N-dimethyl-, monohydrochloride(69-09-0)
Sicherheit
Kennzeichnung gefährlicher: T+,T,F
R-Sätze:: 25-26-39/23/24/25-23/24/25-11
S-Sätze:: 28-36/37-45-16
RIDADR : UN 2811 6.1/PG 1
WGK Germany : 3
RTECS-Nr.: SO1750000
F : 3-10-21
TSCA : Yes
HazardClass : 6.1(b)
PackingGroup : III
HS Code : 29173980
Toxizität: LD50 orally in rats: 225 mg/kg (Goldenthal)

Chlorpromazin-hydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R26:Sehr giftig beim Einatmen.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Crystalline Solid
Verwenden
Antiemetic;Dopamine antagonist
Verwenden
Used as an Antiemetic, Antipsychotic
Definition
ChEBI: The hydrochloride salt of chlorpromazine.
Trademarks
Thorazine (GlaxoSmithKline).
Allgemeine Beschreibung
White or creamy-white odorless crystalline powder with very bitter taste. pH (5% aqueous solution) 4.0-5.5. pH (10% aqueous solution) 4-5.
Allgemeine Beschreibung
Chlorpromazinehydrochloride, 2-chloro-10-[3-(dimethylamino)propyl]phenothiazine monohydrochloride (Thorazine), was the first phenothiazinecompound introduced into therapy. It is still usefulas an antipsychotic. Other uses are in nausea, vomiting, andhiccough. Oral doses of chlorpromazine and thioridazinehave systemic availability of 25% to 35% because of significantfirst-pass metabolism. Chlorpromazine and other phenothiazinesare metabolized extensively by CYP2D6. In contrast, bioavailability of chlorpromazine may beincreased up to 10-fold with injections, but the clinical doseusually is decreased by only threefold to fourfold.Chlorpromazine may weakly induce its own hepatic metabolism,because its concentration in blood is lower after severalweeks of treatment at the same dosage. Alterations of GImotility also may contribute. The drug has significant sedativeand hypotensive properties, possibly reflecting centralhistaminergic and peripheral α1-noradrenergic blockingactivity, respectively. Effects of peripheral anticholinergic activityare common. As with the other phenothiazines, the effectsof other CNS-depressant drugs, such as sedatives andanesthetics, can be potentiated.
Air & Water Reaktionen
Decomposes on exposure to air and light. becoming yellow, pink and, finally, violet. Water soluble.
Reaktivität anzeigen
Chlorpromazine hydrochloride is incompatible in aqueous solution with sodium salts of barbiturates and other alkaline solutions. Solutions may be stabilized by addition of antioxidants and storing under nitrogen.
Brandgefahr
Flash point data for Chlorpromazine hydrochloride are not available; however, Chlorpromazine hydrochloride is probably combustible.
Sicherheitsprofil
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimentalteratogen. Experimental reproductive effects. An anti-emetic and antipsychotic drug. Human systemic effects: anorexia (human), excitement, gastrointestinal changes, irritability, pulse rate increase, respiratory stimulation, rigidity, somnolence, sweating. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and SOx.
Chlorpromazin-hydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
2-Chlorphenothiazin 1-Brom-3-chlorpropan N-Methylmethanamin, gasförmig
Downstream Produkte
Chlorpromazin-hydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 213)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21922 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796ivan@atkchemical.com CHINA 24196 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20580 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 294 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
 
69-09-0(Chlorpromazin-hydrochlorid)Verwandte Suche:
Methyldiphenylamin 3-Chlordiphenylamin N,N-Dimethyl-10H-phenothiazin-10-propanamin N,N,N',N'-Tetramethyl-1,3-propandiamin Diphenylammoniumchlorid 2-Mercapto-5-chloraniliniumchlorid 3-Chlor-N,N-dimethylanilin 2-Chlorphenothiazin 1-Chlor-4-(methylthio)benzol Chlorpromazin-hydrochlorid Phenothiazin CHLORPROMAZINE Topotecan hydrochloride (-)-Methyl(α-methylphenethyl)amin Di-iso-Propylamin Amphetamin 2-Chlor-N,N-dimethyl-10H-pheno-thiazin-10-propanamin Chlordifluormethan
thorazinehydrochloride Chlorpromazine hydrochloride CP2000,BP93 CHLORPOMAZINE HCL CHLORPROMAZINE HYDROCHLORIDE USP CHLOROPROMAZINE HYDROCHLORIDE VETRANAL, 250 MG Hebanil. Klorpromex, 2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine, HCl 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, monohydrochloride 0-(3-dimethylaminopropyl)-2-chlorophenothiazine monohydrochloride 10 -(3 -Dimethylaminopropyl)-2-chloro-10H phenothiazine monohydrochloride 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, Largactil 3-(2-Chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine hydrochlorid Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-, monohydrochloride 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HCL 2-CHLORO-10-[3'-(DIMETHYLAMINO)PROPYL]PHENOTHIAZINE, HCL 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HYDROCHLORIDE 2-CHLORO-N,N-DIMETHYL-10H-PHENOTHIAZINE-10-PROPANAMINE, HCL HEBANIL LARGACTIL LABOTEST-BB LT00452986 KLORPROMEX CHLOROPROMAZIN HYDROCHLORIDE CHLORPROMAZINE HCL Chloropromazine Hydrochlorode ChlorpromazineHydrochloride,98% chlorpromazine hydrochloride IMP 2-: 2-CHLORO-10-(3-DIMETHYLAMINOPROPYL)PHENOTHIAZINE HCL Chlorpromazine hydrochloride, 98%, dopamine receptor and potassium channel inhibitor CPZ, Chlorpromazine hydrochloride 4560rphydrochloride aminazinhydrochloride aminazinmonohydrochloride ampliactilmonohydrochloride Chloractil chloropromazinehydrochloride chlorpromazinemonohydrochloride chlorpromaziniumchloride klorproman largactilmonohydrochloride nci-c05210 neurazine norcozine phenothiazinehydrochloride promacid promapar propaphen propapheninhydrochloride sonazine taroctyl Chlorpromazine hydrochloride,2-Chloro-10-(3-dimethylaminopropyl)phenothiazine hydrochloride, CPZ, Largactil Chlorpromazine Hydrochloride (200 mg) [3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-dimethylamine hydrochloride ChlorpoMazine Hydrochloride 2-Chloro-N,N-diMethyl-10H-phenothiazine-10-propanaMine Hydrochloride 2-Chloro-10-[3-(dimethylamino)-1-propyl]phenothiazine Hydrochloride CHLORPROMAZINE HYDROCHLORIDE 10-(3-dimethylaminopropyl)-2-chlorophenothiazinemonohydrochloride 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazinmonohydrochloride 2-Chloro-10-(3-DimethyAminopropyl)PhenothiazineHydrochloride
Urheberrecht 2017 © ChemicalBook. Alle Rechte vorbehalten.