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Chlorpromazine hydrochloride

Chlorpromazine hydrochloride
Chlorpromazine hydrochloride structure
CAS No.
69-09-0
Chemical Name:
Chlorpromazine hydrochloride
Synonyms
HEBANIL;promacid;promapar;sonazine;taroctyl;LARGACTIL;neurazine;norcozine;propaphen;KLORPROMEX
CBNumber:
CB1492923
Molecular Formula:
C17H20Cl2N2S
Formula Weight:
355.33
MOL File:
69-09-0.mol

Chlorpromazine hydrochloride Properties

Melting point:
192-196°C
Density 
1.2221 (estimate)
Flash point:
9℃
storage temp. 
-20°C Freezer
solubility 
Very soluble in water, freely soluble in ethanol (96 per cent). It decomposes on exposure to air and light.
form 
Powder/Solution
color 
White to off-white or clear colorless
PH
pH (50g/L, 25℃) : 4.0~5.0
Water Solubility 
>=10 g/100 mL at 24 ºC
Merck 
14,2185
BRN 
3779989
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents. Air and light sesnsitive.
CAS DataBase Reference
69-09-0(CAS DataBase Reference)
EPA Substance Registry System
10H-Phenothiazine- 10-propanamine, 2-chloro-N,N-dimethyl-, monohydrochloride(69-09-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+,T,F
Risk Statements  25-26-39/23/24/25-23/24/25-11
Safety Statements  28-36/37-45-16
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  SO1750000
3-10-21
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29173980
Toxicity LD50 orally in rats: 225 mg/kg (Goldenthal)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H330 Fatal if inhaled Acute toxicity,inhalation Category 1, 2 Danger P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P311 Call a POISON CENTER or doctor/physician.
P320 Specific treatment is urgent (see … on this label).
P330 Rinse mouth.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

Chlorpromazine hydrochloride price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1125006 Chlorpromazine hydrochloride United States Pharmacopeia (USP) Reference Standard 69-09-0 200mg $348 2018-11-13 Buy
Sigma-Aldrich 31679 Chlorpromazine hydrochloride VETRANAL , analytical standard 69-09-0 250mg $48.7 2018-11-13 Buy
TCI Chemical C2481 Chlorpromazine Hydrochloride >98.0%(HPLC)(T) 69-09-0 5g $32 2018-11-22 Buy
TCI Chemical C2481 Chlorpromazine Hydrochloride >98.0%(HPLC)(T) 69-09-0 25g $99 2018-11-22 Buy
Alfa Aesar J63659 Chlorpromazine hydrochloride, 98+% 69-09-0 25g $102 2018-11-13 Buy

Chlorpromazine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

Antiemetic;Dopamine antagonist

Uses

Used as an Antiemetic, Antipsychotic

Definition

ChEBI: The hydrochloride salt of chlorpromazine.

brand name

Thorazine (GlaxoSmithKline).

General Description

White or creamy-white odorless crystalline powder with very bitter taste. pH (5% aqueous solution) 4.0-5.5. pH (10% aqueous solution) 4-5.

General Description

Chlorpromazinehydrochloride, 2-chloro-10-[3-(dimethylamino)propyl]phenothiazine monohydrochloride (Thorazine), was the first phenothiazinecompound introduced into therapy. It is still usefulas an antipsychotic. Other uses are in nausea, vomiting, andhiccough. Oral doses of chlorpromazine and thioridazinehave systemic availability of 25% to 35% because of significantfirst-pass metabolism. Chlorpromazine and other phenothiazinesare metabolized extensively by CYP2D6. In contrast, bioavailability of chlorpromazine may beincreased up to 10-fold with injections, but the clinical doseusually is decreased by only threefold to fourfold.Chlorpromazine may weakly induce its own hepatic metabolism,because its concentration in blood is lower after severalweeks of treatment at the same dosage. Alterations of GImotility also may contribute. The drug has significant sedativeand hypotensive properties, possibly reflecting centralhistaminergic and peripheral α1-noradrenergic blockingactivity, respectively. Effects of peripheral anticholinergic activityare common. As with the other phenothiazines, the effectsof other CNS-depressant drugs, such as sedatives andanesthetics, can be potentiated.

Air & Water Reactions

Decomposes on exposure to air and light. becoming yellow, pink and, finally, violet. Water soluble.

Reactivity Profile

Chlorpromazine hydrochloride is incompatible in aqueous solution with sodium salts of barbiturates and other alkaline solutions. Solutions may be stabilized by addition of antioxidants and storing under nitrogen.

Fire Hazard

Flash point data for Chlorpromazine hydrochloride are not available; however, Chlorpromazine hydrochloride is probably combustible.

Safety Profile

Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. An experimentalteratogen. Experimental reproductive effects. An anti-emetic and antipsychotic drug. Human systemic effects: anorexia (human), excitement, gastrointestinal changes, irritability, pulse rate increase, respiratory stimulation, rigidity, somnolence, sweating. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx, and SOx.

Chlorpromazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Chlorpromazine hydrochloride Suppliers

Global( 214)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21954 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 615 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from Chlorpromazine hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Chlorpromazine hydrochloride
69-09-0
US $1.00 / KG 1G 98% 100KG career henan chemical co

Chlorpromazine hydrochloride Spectrum


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