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Desogestrel Produkt Beschreibung

Desogestrel Struktur
54024-22-5
CAS-Nr.
54024-22-5
Bezeichnung:
Desogestrel
Englisch Name:
Desogestrel
Synonyma:
org2969;Cyclosa;Desogen;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL;Desogestrelum;Desogestrel>
CBNumber:
CB2359630
Summenformel:
C22H30O
Molgewicht:
310.47
MOL-Datei:
54024-22-5.mol

Desogestrel Eigenschaften

Schmelzpunkt:
109-110°C
alpha 
D20 +55° (chloroform)
Siedepunkt:
390.62°C (rough estimate)
Dichte
1.0169 (rough estimate)
Brechungsindex
1.5100 (estimate)
storage temp. 
-20°C Freezer
Löslichkeit
Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride.
Aggregatzustand
neat
pka
13.07±0.40(Predicted)
Merck 
14,2926
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
S-Sätze: 24/25
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS-Nr. JF7975000
HS Code  29372390
Giftige Stoffe Daten 54024-22-5(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Desogestrel Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White Solid

Originator

Dicromil,Organol ,W. Germany,1981

Verwenden

A progestogen with low androgenic potency

Manufacturing Process

A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33 ml tetrahydrofuran was added to a potassium-acetylide solution in tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with 2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane 0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.

Therapeutic Function

Progestin

Allgemeine Beschreibung

Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.

Clinical Use

Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.

Desogestrel Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Desogestrel Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 217)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
whatsapp:+8613081092107 julia@hbshuoxi.com CHINA 973 58
Neostar United (Changzhou) Industrial Co., Ltd.
+0086-519-85557386
+0086-519-85557389 marketing1@neostarunited.com CHINA 4135 58
Nanjing Shizhou Biotechnology Co., Ltd
(+86)18013869214
(+86)25-85563444 sean.lv@synzest.com CHINA 2360 58

54024-22-5(Desogestrel)Verwandte Suche:


  • 13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
  • (17α)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
  • (8S,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-11-methylidene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
  • (17R)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
  • (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-methylene-1,2,3,6,7,8,9,10,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol
  • Desogestrel (50 mg)
  • DESTODENE
  • Desogestrel for system suitability, European Pharmacopoeia (EP) Reference Standard
  • Desogestrel, >=99%
  • (8S,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-11-Methylene-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol
  • 13-ethyl-11-methylene-19-dinorpregn-4-en-20-yn-17-o(17-alpha)-1
  • org2969
  • 13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
  • DESOGESTREL
  • (17a)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
  • Cerazette
  • Cyclosa
  • Dicromil
  • Marvelon 150/320
  • 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17.alpha.)-
  • (17β)-13-Ethyl-11-methylene-19-nor-pregn-4-en-20-yn-17-ol
  • DESOGESTRAL
  • 13-Ethyl-11-methylene-18,19-dinor-17α-4-pregnen-20-yn-17-ol
  • Desogestrel, 99%, a third-generation 19-nortestosterone derivative progestogen
  • Desogestrel Solution
  • Desogestrel for system suitability CRS
  • Desogestrel CRS
  • Desogestrel>
  • Desogen
  • Desogestrelum
  • 18,19-Dinorpregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-, (17α)-
  • Desogestrel USP/EP/BP
  • 54024-22-5
  • C22H30O
  • Hormone Drugs
  • Steroid and Hormone
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
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