Boc-N-methyl-L-leucine
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- CAS-Nr.
- 53363-89-6
- Englisch Name:
- Boc-N-methyl-L-leucine
- Synonyma:
- Tyr(Me);BOC-MELEU-OH;BOC-LEU(ME)-OH;BOC-L-MELEU-OH;BOC-ALA(TBU)-OH;BOC-N-ME-LEU-OH;BOC-N-ME-LEUCINE;Boc-N-Me-L-Leu-OH;BOC-BETA-TBU-ALA-OH;BOC-BETA-TBU-ALANINE
- CBNumber:
- CB3197622
- Summenformel:
- C12H23NO4
- Molgewicht:
- 245.32
- MOL-Datei:
- 53363-89-6.mol
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Boc-N-methyl-L-leucine Eigenschaften
- Schmelzpunkt:
- 55-60 °C
- Siedepunkt:
- 338.2±21.0 °C(Predicted)
- Dichte
- 1.053±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- pka
- 4.04±0.21(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
- Optische Aktivität
- [α]20/D 36±2°, c = 1% in methylene chloride
- BRN
- 2373250
- InChI
- InChI=1S/C12H23NO4/c1-8(2)7-9(10(14)15)13(6)11(16)17-12(3,4)5/h8-9H,7H2,1-6H3,(H,14,15)/t9-/m0/s1
- InChIKey
- YXJFAOXATCRIKU-VIFPVBQESA-N
- SMILES
- C(O)(=O)[C@H](CC(C)C)N(C(OC(C)(C)C)=O)C
- CAS Datenbank
- 53363-89-6(CAS DataBase Reference)
Boc-N-methyl-L-leucine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Boc-N-methyl-L-leucine is the BOC (tert-butyloxycarbonyl) protected N-methylated leucine. The N-methylated amino acid is quite useful in the peptide synthesis, giving a lot of improved properties to peptide. Studies have shown that peptide containing N-methylated amino acids obtain increased proteolytic stability, increased membrane permeability, and altered conformation. The effects of N-methylated amino acids are quite important in the development of therapeutic peptide compound as well as in the assay of biological activity of some modified peptides. BOC group can be easily removed by treatment with strong acids such as trifluoroacetic acid.
Biologische Aktivität
Boc-N-methyl-L-leucine is a peptidyl nucleobase that has been shown to inhibit tumor cell growth and induce tumor regression in animal models. It is an amide of leucine and the antibiotic aminouracil, which is a guanine analogue. Boc-N-methyl-L-leucine has also shown to inhibit tumor growth by inhibiting mitochondrial membrane potential, which may lead to cell death in cancer cells. This compound has been shown to be effective against both solid tumors and leukemia cell lines. Boc-N-methyl-L-leucine also inhibits the proliferation of human prostate cancer cells by blocking the synthesis of nucleic acids and proteins.
Einzelnachweise
https://en.wikipedia.org/wiki/Tert-Butyloxycarbonyl_protecting_group
http://pubs.acs.org/doi/abs/10.1021/cr030024z?src=recsys&journalCode=chreay
Boc-N-methyl-L-leucine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Boc-N-methyl-L-leucine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 172)Lieferanten
53363-89-6()Verwandte Suche:
- N-ALPHA-T-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
- N-ALPHA-T-BUTOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
- N-ALPHA-T-BUTOXYCARBONYL-BETA-T-BUTYL-L-ALANINE
- N-ALPHA-T-BUTOXYCARBONYL-GAMMA-METHYL-L-LEUCINE
- N-ALPHA-TERT-BUTYLOXYCARBONYL-N-ALPHA-METHYL-L-LEUCINE
- N-ALPHA-T-BOC-N-ALPHA-METHYL-L-LEUCINE
- BOC-BETA-TBU-ALANINE
- BOC-BETA-TBU-ALA-OH
- BOC-BETA-T-BUTYL-L-ALANINE
- BOC-ALA(TBU)-OH
- BOC-N-ME-LEUCINE
- BOC-N-ME-LEU-OH
- BOC-N-METHYL-L-LEUCINE
- BOC-N-METHYL-L-LEU-OH
- BOC-MELEU-OH
- BOC-NEOPENTYLGLYCINE
- BOC-(NEOPENTYL)GLY-OH
- BOC-N-ALPHA-METHYL-L-LEUCINE
- BOC-L-BETA-T-BUTYLALANINE
- BOC-LEU(ME)-OH
- BOC-L-NEOPENTYLGLYCINE
- BOC-L-MELEU-OH
- BOC-T-BUTYL-L-ALANINE
- N-ALPHA-TERT-BUTYLOXYCABONYL-N-ALPHA-METHYL-L-LEUCINE
- DANSYL-L-GLUTAMIC ACID BIS(CYCLOHEXYLAMMONIUM)
- NALPHA-tert-Butoxycarbonyl-N-methyl-L-leucine
- N-tert-Butyloxycarbonyl-N-methyl-L-leucine
- N-(tert-butoxycarbonyl)-N-methyl-L-leucine
- L-Leucine, N-[(1,1-diMethylethoxy)carbonyl]-N-Methyl-
- (S)-2-((tert-butoxycarbonyl)(Methyl)aMino)-4-Methylpentanoic acid
- Tyr(Me)
- Boc-N-Me-L-Leu-OH
- Boc-N-Me-Leu-OH
- Boc-N-Methyl Leucine
- Boc-N-methyl-L-leucine98+%
- N-α-t-butoxycarbonyl-β-t-butyl-L-alanine
- (Tert-Butoxy)Carbonyl N-Me-Leu-OH
- (2S)-2-{[(tert-butoxy)carbonyl](methyl)amino}-4-methylpentanoic acid
- (2S)-4-methyl-2-[methyl-[(2-methylpropan-2-yl)oxy-oxomethyl]amino]pentanoic acid
- Boc-N-L-methylleucine
- Boc-N-methyl-L-leucine USP/EP/BP
- 2-((TERT-BUTOXYCARBONYL)(METHYL)AMINO)-4-METHYLPENTANOIC ACID
- N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-L-leucine
- N-BOC-N-Methyl-L-leucine
- BOC-N-methyl tert leucine
- 53363-89-6
- Peptide Synthesis
- N-Methyl Amino Acids
- Unnatural Amino Acid Derivatives
- Specialty Synthesis
- amino acids
- Amino Acid Derivatives
- N-Methyl Amino Acids
