Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
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- CAS-Nr.
- 141942-85-0
- Englisch Name:
- Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
- Synonyma:
- ATS-5;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;RETINCIC ACID;Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;Atorvastatin Impurity 166;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric
- CBNumber:
- CB5188978
- Summenformel:
- C7H11NO3
- Molgewicht:
- 157.17
- MOL-Datei:
- 141942-85-0.mol
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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Eigenschaften
- alpha
- -5 º (neat)
- Siedepunkt:
- 270 °C(lit.)
- Dichte
- 1.114 g/mL at 25 °C(lit.)
- Brechungsindex
- n20/D 1.448(lit.)
- Flammpunkt:
- >230 °F
- storage temp.
- 2-8°C
- Löslichkeit
- Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
- pka
- 13.03±0.20(Predicted)
- Aggregatzustand
- Liquid
- Wichte
- 1.114
- Farbe
- Colorless to yellow
- Optische Rotation
- [α]25/D 5°, neat
- BRN
- 5328715
- InChIKey
- LOQFROBMBSKWQY-ZCFIWIBFSA-N
- CAS Datenbank
- 141942-85-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi |
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| R-Sätze: |
36/37/38 |
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| S-Sätze: |
26-36 |
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| WGK Germany |
1 |
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| HS Code |
29269090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P337+P313 |
Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
yellow liquid
Application
Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 424)Lieferanten
141942-85-0()Verwandte Suche:
- (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
- (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
- (R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
- (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
- (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
- ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE
- ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
- ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE
- Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
- ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE
- ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE
- BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R)
- BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S)
- thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate
- (3R)-4-cyano-3-hydroxybutyric acid ethyl ester
- FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate
- Atorvastatin interMediates Ats-5
(R)-4-cyano-3-hydrobutyric acid ethyl ester
- Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)-
- (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester
- ethyle(R)-4-cyano-3-hydroxybutanoate
- (R)-4-Cyano-3-hydroxy butanoate
- (R)-4-cyano-3-hydroxybutyric
- R(-)-4-cyano-3-hydroxybutyrtc ethyl ester
- ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE
- R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER
- R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5
- R(-)-4-Cyano-3-hydroxubutyricethylester
- (R)-4-Cyano-3-hydroxybuttersureethylester
- (R)-4-cyano-3-hydrobutyric acid ethyl ester
- (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
- RETINCIC ACID
- [R]-[-]-Ethyl-cyano-3-hydroxybutyrate
- (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester
- Ethyl (R)-4-cyano-3-hydroxybutanoate,99%
- Ethyl (R)-4-cyano-3-hydroxybutanoate,95%
- Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester
- Ethyl (R)-(-)-4-cyan
- 4-Cyano-3-hydroxy-butyric acid ethyl ester
- )-4-cyano-3-hydroxybutyrate
- Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1)
- (R)-Ethyl 4-cyano-3-
- Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
- Ats-5(For Atorvastatin)
- Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >
- (R)-(-)-4-Cyano-3-hydroxybutyrate
- Atorvastatin Impurity 127
- (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl
- (R)-(-)-4-CYANO-3-HYDROXYBUTYATE
- (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is
(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of
(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of
(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester
- ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE
- ATS-5
- Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate(ATS-5)
- Atorvastatin calcium impurity 63
- ethyl (R)-3-hydroxy-4-cyano-butyrate
- Atorvastatin Impurity 166
- Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate
- 141942-85-0
- 41942-85-0
