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6-아미노 카프로산

6-아미노 카프로산
6-아미노 카프로산 구조식 이미지
카스 번호:
60-32-2
한글명:
6-아미노 카프로산
동의어(한글):
6-아미노카프로산;아미노캅프로산;ε-아미노카프로산;아미노캅프로산;6-아미노카프로익애씨드;아미노카프로익애씨드;아미노카프로익애씨드및그염류;6-아미노캅프로 산;6-아미노-헥사오익 산;6-아미노헥산오익 산;6-아밈노-N-헥산오익 산;아미노캅프로 산;아미카르;엡실론-노르루신;엡실론-루신;엡실론-아미노-N-캅프로 산;엡실론-아미노캅프로 산;엡실론-아미노헥산오익 산;엡실카프라민;오메가-아미노캅프로 산
상품명:
6-Aminocaproic acid
동의어(영문):
ACS;EACS;EACA;177jd;cy116;Hepin;Amikar;Amicar;CY 116;177 J.D
CBNumber:
CB5223888
분자식:
C6H13NO2
포뮬러 무게:
131.17
MOL 파일:
60-32-2.mol

6-아미노 카프로산 속성

녹는점
207-209 °C (dec.) (lit.)
끓는 점
242.49°C (rough estimate)
밀도
1.042 g/cm3
증기압
<0.1 hPa (20 °C)
굴절률
1.4870 (estimate)
인화점
207-209°C
저장 조건
Store below +30°C.
용해도
H2O: 50 mg/mL
물리적 상태
powder
산도 계수 (pKa)
4.373(at 25℃)
색상
white
수소이온지수(pH)
7.0-7.5 (50g/l, H2O, 20℃)
냄새
Odorless
수용성
SOLUBLE
Merck
14,432
BRN
906872
InChIKey
SLXKOJJOQWFEFD-UHFFFAOYSA-N
CAS 데이터베이스
60-32-2(CAS DataBase Reference)
NIST
Hexanoic acid, 6-amino-(60-32-2)
EPA
Hexanoic acid, 6-amino- (60-32-2)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 2
RTECS 번호 MO6300000
TSCA Yes
HS 번호 29224995
유해 물질 데이터 60-32-2(Hazardous Substances Data)
독성 LD50 in rats (g/kg): 7.0 i.p.; ~3.3 i.v. (Hallesy)
기존화학 물질 KE-01382
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H320 눈에 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2B 경고 P264, P305+P351+P338,P337+P313
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
NFPA 704
1
2 0

6-아미노 카프로산 MSDS


6-Aminohexanoic acid

6-아미노 카프로산 C화학적 특성, 용도, 생산

화학적 성질

white crystalline powder

Originator

Epsilon,Roche,W. Germany,1962

용도

hemostatic

용도

6-Aminohexanoic Acid is a reagent commonly used for the extraction of aldehydes from reaction mixtures. 6-Aminohexanoic Acid has also been shown to improve solubilization of membrane proteins in elect rophoresis. Studies suggest that 6-Aminohexanoic Acid inhibits the activation of the first component of the complement system.

용도

Propylparaben Food preservative

용도

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.

정의

ChEBI: An amino-acid anion that is the conjugate base of 6-aminohexanoic acid.

Manufacturing Process

5 kg of caprolactam were heated with 40 liters of water in a pressure vessel at 250°C for a period of four hours. These quantities of reactants correspond to a water:lactam molecular ratio of 50:1. After cooling, the small quantity of the nonsoluble substance that is formed is filtered off, and the filtrate is evaporated as far as possible. The resulting concentrate is mixed with three times its volume of strong alcohol, thereby causing the desired product, epsilon-aminocaproic acid (6-aminohexanoic acid), to crystallize out. After separating the crystalline product thus obtained, a further quantity of epsilonaminocaproic acid can be obtained from the mother liquid if desired.

상표명

Amicar (Xanodyne).

Therapeutic Function

Antifibrinolytic

Mechanism of action

Because binding of plasminogen or plasmin to fibrinogen or fibrin is mediated by lysine groups that are part of the structures of fibrin and fibrinogen, aminocaproic acid, which is a structural analog of lysine that only differs in that it has one less amino group, acts as a competitive inhibitor for binding of plasmin(ogen) to fibrin. Aminocaproic acid shifts the homeostatic balance on the side of coagulation, thus restoring fibrinolytic mechanism activity. Aminocaproic acid, which is not a procoagulant, such as those used during surgical intervention and various pathological conditions, is accompanied by an elevation in fibrinolytic activity of blood and tissue. It is used to stop bleeding.

Safety Profile

Moderately toxic by intravenous route. Human systemic effects by ingestion: changes in tubules (includmg acute renal failure, acute tubular necrosis), hematuria, and increased body temperature. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits toxic fumes such as NOx,.

Chemical Synthesis

Aminocaproic acid (24.4.1) is synthesized by hydrolyzing ε -caprolactam at high temperature.

Veterinary Drugs and Treatments

Aminocaproic acid has been used as a treatment to degenerative myelopathy (seen primarily in German shepherds), but no controlled studies documenting its efficacy were located. There is interest in evaluating aminocaproic acid for adjunctive treatment of thrombocytopenia in dogs, but efficacy and safety for this purpose remains to be investigated. In humans, it is primarily used for treating hyperfibrinolysis-induced hemorrhage.

6-아미노 카프로산 준비 용품 및 원자재

원자재

준비 용품


6-아미노 카프로산 공급 업체

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