4-Methylacetophenon Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S27:Beschmutzte, getränkte Kleidung sofort ausziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
4'-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. May be prepared
by slow addition of acetyl chloride to a mixture of toluene and
AlCl in an ice bath and under vacuum, maintaining the temperature
at +5°C and then letting it increase to +20°C.
Chemische Eigenschaften
4'-Methylacetophenone has
been identified in Brazilian rosewood oil and in pepper. It occurs as colorless crystals with a floral, sweet odor that is milder than that of acetophenone.
4-Methylacetophenone is prepared from toluene and acetic anhydride or acetyl
chloride by a Friedel–Crafts reaction. It is used for blossom notes in mimosaand
hawthorn-type perfumes, especially soap perfumes.
Occurrence
Reported found in the essential oil distilled from the wood of Myrocarpus fastigiatus, Myrocarpus frondo sus, Bois de Rose. Also reported found in sour cherry, orange and grapefruit peel oil, black currants, guava, peach, blackberry,
celery, potato, tomato, mentha oils, pepper, parsley, smoked fish, cognac, parmesan cheese, cocoa, tea, soybean, cloudberry,
mango, cauliflower, broccoli, rice bran, buckwheat, dried bonito, cherimoya, calabash nutmeg and mastic gum leaf oil, cooked
cabbage, mandarin juice.
Verwenden
4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate.
synthetische
By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the
temperature at +5°C and then letting it increase to +20°C.
Definition
ChEBI: 4'-Methylacetophenone is an aromatic ketone. It is a metabolite found in or produced by Saccharomyces cerevisiae.
Allgemeine Beschreibung
4′-Methylacetophenone is a clear colourless to pale yellowish liquid that occurs naturally in mango, tomato and orange.
Sicherheitsprofil
Moderately toxic by
ingestion. A human skin irritant. A
flammable liquid. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also KETONES.
läuterung methode
Impurities, including the o-and m-isomers, are removed by forming the semicarbazone (m 212-213.5o) which, after repeated crystallisation, is hydrolysed to the ketone. [Brown & Marino J Am Chem Soc 84 1236 1962.] It can also be purified by distillation under reduced pressure, followed by low temperature crystallisation from isopentane. [Beilstein 7 IV 701.]
4-Methylacetophenon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE
4-Acetylbenzoesaeure
5-P-TOLYL-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE
4-(1,2,3-THIADIAZOL-4-YL)BENZALDEHYDE
4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE
4-(1,2,3-THIADIAZOL-4-YL)BENZOYL CHLORIDE
CYAZOFAMID
4-Ethynyltoluene
ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE
4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE
Naphthalene, 1,2,3,4-tetrahydro-1,6-dimethyl-4-(1-methylethyl)-, (1R,4R)-rel-
ar-turmerone
2-Brom-4'-methylacetophenon
Methyl-p-toluat
3,5-DIBROMO-4-METHYLBENZOIC ACID
2-AMINO-4-(P-TOLYL)THIAZOLE
1-(4-(Bromomethyl)phenyl)ethanone
