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Acetophenon Produkt Beschreibung

CAS-Nr.98-86-2
Bezeichnung:Acetophenon
Englisch Name:Acetophenone
Synonyma:
Dymex;HYPNONE;FEMA 2009;Acetofenon;Acetophene;hypnon[qr];phenacycle;usafek-496;Acetophenon;ACETPHENONE
CBNumber:CB5694882
Summenformel:C8H8O
Molgewicht:120.15
MOL-Datei:98-86-2.mol
Acetophenon physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 19-20 °C(lit.)
Siedepunkt:: 202 °C(lit.)
Dichte: 1.03 g/mL at 25 °C(lit.)
Dampfdichte: 4.1 (vs air)
Dampfdruck: 0.45 mm Hg ( 25 °C)
Brechungsindex: n20/D 1.534(lit.)
FEMA : 2009 | ACETOPHENONE
Flammpunkt:: 180 °F
storage temp. : 2-8°C
Löslichkeit: 6.1g/l
Aggregatzustand: Liquid
Farbe: Clear colorless to light yellow
Relative polarity: 4.4
Explosionsgrenze: 1.4-5.2%(V)
Wasserlöslichkeit: 5.5 g/L (20 ºC)
Merck : 14,73
JECFA Number: 806
BRN : 605842
Expositionsgrenzwerte: No exposure limits are set. The health hazard from exposure to this compound should be low, due to its low vapor pressure and low toxicity.
Stabilität:: Stable. Incompatible with strong oxidizing agents, strong bases, strong reducing agents. Combustible.
CAS Datenbank: 98-86-2(CAS DataBase Reference)
NIST chemische Informationen: Acetophenone(98-86-2)
EPA chemische Informationen: Ethanone, 1-phenyl-(98-86-2)
Sicherheit
Kennzeichnung gefährlicher: Xn,T,F
R-Sätze:: 22-36-63-43-36/37/38-23/24/25-45-39/23/24/25-11-67-40
S-Sätze:: 26-36/37-24/25-23-53-45-16-7
RIDADR : UN 1593 6.1/PG 3
WGK Germany : 1
RTECS-Nr.: AM5250000
F : 8
Selbstentzündungstemperatur: 570 °C
TSCA : Yes
HS Code : 29143900
Giftige Stoffe Daten: 98-86-2(Hazardous Substances Data)
Toxizität: LD50 orally in rats: 0.90 g/kg (Smyth, Carpenter)

Acetophenon Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT ODER WEISSE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH.
ARBEITSPLATZGRENZWERTE
TLV: 10 ppm (als TWA); (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20°C tritt langsam eine gesundheitsschädliche Kontamination der Luft ein; viel schneller jedoch beim Versprühen oder Dispergieren.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen. Möglich sind Auswirkungen auf das Zentralnervensystem. Exposition gegenüber hohen Konzentrationen kann zu Bewusstlosigkeit führen.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Die Flüssigkeit entfettet die Haut.
LECKAGE
Ausgelaufene Flüssigkeit möglichst in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, A/P2-Filter für organische Dämpfe und schädlichen Staub.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R43:Sensibilisierung durch Hautkontakt möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R45:Kann Krebs erzeugen.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R11:Leichtentzündlich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
S7:Behälter dicht geschlossen halten.
Aussehen Eigenschaften
C8H8O; Methylphenylketon, Acetylbenzol. Farblose Flüssigkeit mit charakteristischem Geruch.
Gefahren für Mensch und Umwelt
Gesundheitsschädlich beim Verschlucken. Reizt die Augen. Resorption führt zur Narkose.
Nicht mit starken Oxidationsmitteln, Laugen und Säuren in Berührung bringen.
LD50 (oral, Ratte): 815 mg/kg
Schutzmaßnahmen und Verhaltensregeln
Geeignete Schutzhandschuhe als kurzzeitiger Spritzschutz.
Verhalten im Gefahrfall
Mit flüssigkeitsbindendem Material, z.B. Rench Rapid aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Kohlendioxid, Pulver, Schaum.
Brennbar. Im Brandfall kann Kohlenmonoxid entstehen.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abspülen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 10 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft.
Nach Verschlucken: Reichlich Wasser trinken lassen. Erbrechen auslösen. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag

Sachgerechte Entsorgung
Als halogenfreie, organische Lösemittelabfälle.
Beschreibung
Acetophenone is the simplest aromatic ketone and is a clear liquid/crystal and very slightly soluble in water with a sweet pungent taste and odour resembling oranges. It is used as a polymerisation catalyst for the manufacture of olefins. Acetophenone is used in perfumery as a fragrance ingredient in soaps, detergents, creams, lotions, and perfumes; as a flavouring agent in foods, non-alcoholic beverages, and tobacco; as a specialty solvent for plastics and resins; as a catalyst for the polymerisation of olefins; and as a photosensitiser in organic syntheses. Acetophenone is a raw material for the synthesis of some pharmaceuticals and is also listed as an approved excipient by the U.S. FDA. Acetophenone occurs naturally in many foods such as apple, apricot, banana, and beef. Acetophenone has been detected in ambient air and drinking water; exposure of the general public may occur through the inhalation of contaminated air or the consumption of contaminated water. It is highly flammable and will get easily ignited by heat, sparks, or flames, and the vapours may form explosive mixtures with air.
Chemische Eigenschaften
Acetophenone is a colorless, oily liquid with a sweet, floral odor.
Chemische Eigenschaften
is a naturally occurring component of a large number of foods and essential oils. It is a colorless liquid with a penetrating sweet odor, reminiscent of orange blossom.
Acetophenone can be hydrogenated catalytically to 1-phenylethanol. It is obtained as a by-product in the Hock phenol synthesis and is purified from the high-boiling residue by distillation. The quantities obtained from this source satisfy the present demand.
Acetophenone is used for perfuming detergents and industrial products and is an intermediate in the synthesis of other fragrance materials.
Chemische Eigenschaften
Acetophenone has a characteristic sweet, pungent and strong medicinal odor with a bitter, aromatic cherry branch taste. It is useful in flavors of grape, cherry and tobacco
Chemische Eigenschaften
yellow liquid
Occurrence
Reported found in cocoa, beef, raspberry, peas, and concord grape
Verwenden
Acetophenone is used in perfumery, as aphotosensitizer in organic synthesis, and asa catalyst in olefin polymerization.
Verwenden
Acetophenone is a reagent used in the production of fragrances and resin polymers.
Verwenden
In perfumery to impart an orange-blossom-like odor; catalyst for the polymerization of olefins; in organic syntheses, especially. as photosensitizer.
Definition
ChEBI: A methyl ketone that is acetone in which one of the hydrogens of the methyl group has been replaced by a phenyl group.
synthetische
From benzene and acetylchloride in the presence of aluminum chloride or by catalytic oxidation of ethyl benzene; also prepared by fractional distillation and crystallization from the essential oil of Stirlingia latifolia.
Aroma threshold values
Detection: 170 ppb; Recognition: 2.9 ppm
Taste threshold values
Taste characteristics at 10 ppm: sweet, nutty, benzaldehyde with musty, fruity notes
Allgemeine Beschreibung
A colorless liquid with a sweet pungent taste and odor resembling the odor of oranges. Melting point 20.5°C (68.9°F); freezes under cool conditions. Slightly soluble in water and denser than water. Hence sinks in water. Vapor heavier than air. Flash point 180°F. A mild irritant to skin and eyes. Vapors can be narcotic in high concentrations. Used as a flavoring, solvent, and polymerization catalyst.
Air & Water Reaktionen
Slightly soluble in water.
Reaktivität anzeigen
Acetophenone reacts with many acids and bases liberating heat and flammable gases (e.g., H2). Reacts with many oxidizing agents. Reacts with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. The amount of heat in these reactions may be sufficient to start a fire in the unreacted portion. Incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides.
Health Hazard
No toxicity expected from inhalation or ingestion except slight narcotic effect. Liquid can cause eye and skin irritation on contact.
Health Hazard
Acetophenone is an irritant, mutagen, and amildly toxic compound. In rabbits 0.77 mgproduced severe eye irritation, but the actionon skin was mild. In mice, subcutaneousadministration of this compound producedsleep; a dose of 330 mg/kg was lethal.
LD50 value, intraperitoneal (mice): 200mg/kg
No symptoms of severe toxicity, nor its carcinogenicityin humans, has been reported..
Brandgefahr
Combustible liquid; flash point (closed cup) 82°C (180°F); vapor pressure 1 torr at 37°C (98.6°F); vapor density 4.1 (air = 1); autoignition temperature 570°C (1058°F); fire-extinguishing agent: dry chemical, foam, or CO2; water may cause frothing, but it can be used to flush and dilute the spill. Its reaction with strong oxidizers may be violent.
Sicherheitsprofil
Poison by intraperitoneal and subcutaneous routesModerately toxic by ingestion. A skin and severe eye irritant. Mutation data reported. Narcotic in high concentration. A hypnotic. Flammable liquid. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and fumes. See also IGTONES
mögliche Exposition
Acetophenone is used as a solvent and in perfume manufacture to impact a pleasant jasmine or orange-blossom odor. It is used as a catalyst in olefin polymerization and as a flavorant in tobacco. It is also used in the synthesis of pharmaceuticals
Enzyminhibitor
This aromatic ketone (FW = 120.15 g/mol; CAS 98-86-2; M.P. = 20.5°C; B.P. = 202°C; slightly soluble in water) inhibits carboxylase, aldehyde dehydrogenase (NAD+), K = 48 μM, chymotrypsin, esterase, lipase, NAD ADP-ribosyltransferase, poly (ADP-ribose) polymerase, IC50 = 2.3 mM, tyrosinase, or monophenol monooxygenase, IC50 = 0.85 mM, catechol 2,3-dioxygenase.
Erste Hilfe
Remove any contact lenses at once, then flush eyes, wash contaminated areas of body with soap and water. If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Versand/Shipping
UN1993 Flammable liquids, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, Technical Name Required.
läuterung methode
Dry it by fractional distillation or by standing with anhydrous CaSO4 or CaCl2 for several days, followed by fractional distillation under reduced pressure (from P2O5, optional), and careful, slow and repeated partial crystallisations from the liquid at 0o excluding light and moisture. It can also be crystallised at low temperatures from isopentane. Distillation can be followed by purification using gas-liquid chromatography [Earls & Jones J Chem Soc, Faraday Trans 1 71 2186 1975.] [Beilstein 7 H 271, 7 IV 619.] § A commercial polystyrene supported version is available — scavenger resin (for diol substrates).
Inkompatibilitäten
May form explosive mixture with air. See flash point, above. Reacts violently with strong oxidizers, many acids, bases, amines, amides, and inorganic hydroxides; alkali metals; hydrides, and nitrides. Reacts with reducing agents; alkali metals; hydrides, nitrides. Contact with all preceding materials release heat and flammable gases, including hydrogen; the heat may be sufficient enough to result in fire. Incompatible with aldehydes, aliphatic amines, alkanolamines, cyanides, isocyanates, organic acids, peroxides; perchloric acid. May attack plastics, and some rubbers and coatings
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration, preferably with a flammable solvent
Acetophenon Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Styrol Acetylchlorid Ethylbenzol Chloressigsäureanhydrid 2-Phenylethanol Pentan Naphthensuren, Cobaltsalze Calciumdi(acetat) Calciumdibenzoat
Downstream Produkte
Calcium-(2R-cis)-hydrogen(3-methyloxiranyl)phosphonat Miconazolnitrat Hydratropaldehyd 4-[3-[4-(1,1-Dimethylethyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholin 2,5-Diphenyloxazol alpha-Methylbenzolmethanol DL-α-Methylbenzylamin 4,4,4-Trifluor-1-phenylbutan-1,3-dion Acebutolol 1-Methyl-2-phenylindol 1-Methyl-2-phenyl-1H-indol-3-carbaldehyd 1-Phenylbutan-1,3-dion 1-Phenylethylamin (1) Fosfomycin 3,5-Diphenyl-1H-pyrazol 2-(2-Iminothiazolidin-3-yl)-1-phenylethan-1-onmonohydrobromid Ethyl-2,3-epoxy-3-phenylbutyrat Econazol
Acetophenon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 292)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153sales@crovellbio.com CHINA 407 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Changzhou Ditong Chemical Co.,Ltd
0519-88299272
info@edengenechem.com CHINA 1218 58
Hebei Chisure Biotechnology Co., Ltd.
+8613091036086; +8613292890173
+8613292893290sandy@speedgainpharma.com; luna@speedgainpharma.com CHINA 1019 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23983 58
 
98-86-2(Acetophenon)Verwandte Suche:
Cyclohexanon Phenylessigsure 2-Methylacetophenon Benzil 4'-Bromacetophenon 4'-Hydroxyacetophenon 2,4-Dichloro-5-fluoroacetophenone Basic Violet 1 Dichloracetonitril Methyl-4-hydroxybenzoat Phenylaceton Citric acid monohydrate Acetonitril 4-Methylacetophenon 3'-Nitroacetophenon Methyl 4-Methoxyacetophenon Kresoxim-methyl
Acetophene ACETOPHENONE extrapure AR PHENYL METHYL KETONE 1-Phenyl-1-ethanone 1-phenyl-ethanon 1-Phenylethanone (acetophenone) 1-phenylethanone[qr] Acetofenon Acetophenon acetophenon[qr] acetyl-benzen usafek-496[qr] ACETPHENONE ACETOPHENONE ACETYLBENZENE AKOS BBS-00003215 alpha-Acetophenone 1-Phenylethanone METHYL PHENYL KETONE BENZOYL METHIDE HYPNONE FEMA 2009 acetybenzene ACETOPHENONE, 1X1ML, CH2CL2, 2000UG/ML ACETOPHENONE, STANDARD FOR GC ACETOPHENONE, REAGENTPLUS, 99% ACETOPHENONE 98+% FCC ACETOPHENONE, 1000MG, NEAT Acetophenone, 98%, extra pure Acetophenone ,98% Acetophenone 5g [98-86-2] Acetophenone 10g [98-86-2] Acetophenone, extra pure, 98% 1LT Acetophenone, extra pure, 98% 250ML Acetophenone, extra pure, 98% 5ML Acetylbenzene Methyl Phenyl Ketone ACETOPHENONE FOR SYNTHESIS 100 ML ACETOPHENONE FOR SYNTHESIS 1 L ACETOPHENONE (Methyl-13C, 99%) Acetophenone, Standard for GC,>=99.5%(GC) Acetophenone puriss. p.a., >=99.0% (GC) Acetophenone ReagentPlus(R), 99% 2,4-DIFLUORO-ALPHA-(1H-1,2,4-TRIAZOLE)ACETOPHENONE Methyl phenyl ketone Acetylbenzene acetylbenzene[qr] Acetylbenzol Benzene, acetyl- benzene,acetyl-[qr] Benzoylmethane benzoylmethide[qr] Dymex Ethanone, 1-phenyl- Ethanone,1-phenyl- ethanone,1-phenyl-[qr] Acetophenone PG, 99% ACETOPHENONE GC STANDARD Acetopneone Acetophenone(Acetylbenzene),99%
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