Chinese english Germany Japanese Korea

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Struktur
1448189-80-7
CAS-Nr.
1448189-80-7
Englisch Name:
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Synonyma:
VHL Ligand 1;ULM-1;ULM-1(MDK7526HCL);VHL Ligand 1 HCl salt;141003;CS-2718;ULM-1 HCl;UBI-10003;MDK7526 HCl;MDK-7526;ULM-1
CBNumber:
CB63156669
Summenformel:
C22H31ClN4O3S
Molgewicht:
467.03
MOL-Datei:
1448189-80-7.mol
Request For Quotation

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Eigenschaften

storage temp. 
2-8°C
Löslichkeit
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
Aggregatzustand
A crystalline solid
InChIKey
JYRTWGCWUBURGU-XIMRXPCLNA-N
SMILES
C([C@@H]1C[C@@H](O)CN1C(=O)[C@@H](N)C(C)(C)C)(=O)NCC1C=CC(C2=C(N=CS2)C)=CC=1.Cl |&1:1,3,9,r|

Sicherheit

HS Code  2934100090

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

VHL ligand 1 is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs). It is the von Hippel-Lindau (VHL) E3 ligase binding portion of some VHL-based PROTACs, including BET PROTAC MZ1 (Item No. 21622).

Verwenden

(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487) used as a negative control.

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 140)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Suzhou Origin Specialty Chemicals Co., Ltd.
+86-512-68662322 +86-17312436797
 hanqun@origsc.com China 776 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810
 sales@anbuchem.com China 3000 58
Chongqing Zhihe Biopharmaceutical Co., Ltd. 		+86-18580541567 +86-17782035140
 sales@zhswyy.com China 338 58
Shanghai finete Pharmaceutical Co., Ltd. 		+86-18221039705
CHINA 139 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830
 figo.gao@foxmail.com China 6992 58
Accela ChemBio Inc. 		(+1)-858-699-3322
info@accelachem.com United States 19965 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795
info@shochem.com CHINA 288 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674;
 laboratory@coreychem.com China 30255 58
  • (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
  • Protein degrader 1 (hydrochloride)
  • (S,R,S)-AHPC hydrochloride
  • MDK-7526;ULM-1
  • (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide hydrochloride
  • Protein degrader 1
  • 141003
  • (2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide hydrochloride
  • CS-2718
  • Degradation Inducing Moiety A
  • PROTEIN DEGRADER 1 HYDROCHLORIDE; MDK7526 HCL; MDK7526; MDK-7526; MDK 7526; VHL LIGAND 1; ULM-1; VH032 DESACETYL HYDROCHLORIDE; VH032 AMINE HCL; DEGRADATION INDUCING MOIETY A;
  • VH032 amine HCl
  • VH032 desacetyl Hydrochloride
  • MDK7526 HCl
  • (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine
  • VHL Ligand 1 (hydrochloride)
  • PROTAC-VHL-Ligand 1
  • ULM-1 HCl
  • PROTAC-VHL-ligand hydrochloride
  • (S,R,S)-AHPC hydrochloride >=97%
  • MDK7526(Protein degrader 1)
  • (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride ISO 9001：2015 REACH
  • VH032-NH2 hydrochloride
  • VHL ligand 1 hydrochlorid
  • Protein degrader 1 HCl)
  • ULM-1HCl (MDK7526 HCl
  • ULM-1
  • VHL Ligand 1
  • ULM-1(MDK7526HCL)
  • VHL Ligand 1 HCl salt
  • UBI-10003
  • (S,R,S)-AHPC (VH032-NH2) hydrochloride
  • L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-, HCl
  • (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride, E3 Ligase ligand, Ligand for PROTAC? research, VH032
  • (S,R,S)-AHPC (monohydrochloride)
  • 1448189-80-7
Copyright 2019 © ChemicalBook. All rights reserved