Anthra[1,9-cd]pyrazol-6(2H)-on
|
|
|
- CAS-Nr.
- 129-56-6
- Bezeichnung:
- Anthra[1,9-cd]pyrazol-6(2H)-on
- Englisch Name:
- 1,9-Pyrazoloanthrone
- Synonyma:
- SP600125;pyrazolanthrone;1PMV;JNKII;CS-548;Nsc75890;Anthra H;c.i.70300;Pyrazoxanone;SP600125 >99%
- CBNumber:
- CB6354608
- Summenformel:
- C14H8N2O
- Molgewicht:
- 220.23
- MOL-Datei:
- 129-56-6.mol
|
Anthra[1,9-cd]pyrazol-6(2H)-on Eigenschaften
- Schmelzpunkt:
- 281~282℃
- Siedepunkt:
- 361.16°C (rough estimate)
- Dichte
- 1.1702 (rough estimate)
- Brechungsindex
- 1.5910 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- H2O: insoluble
- Aggregatzustand
- Yellowish orange solid
- pka
- 11.75±0.20(Predicted)
- Farbe
- yellow
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
- InChIKey
- ACPOUJIDANTYHO-UHFFFAOYSA-N
- CAS Datenbank
- 129-56-6(CAS DataBase Reference)
- EPA chemische Informationen
- Anthra[1,9-cd]pyrazol-6(2H)-one (129-56-6)
Anthra[1,9-cd]pyrazol-6(2H)-on Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
A broad-spectrum serine/threonine kinase inhibitor of JNK with an IC50 range from 40 to 90 nM.
Definition
ChEBI: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Allgemeine Beschreibung
A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC
50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of
c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of
c-Jun transcription.
Biologische Aktivität
Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40-90 nM) with negligible activity at ERK2, p38 β and a range of enzymes (IC 50 > 10 μ M). Active in vivo . Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Also available as part of the MAPK Inhibitor Tocriset™ .
Sicherheitsprofil
Poison by intravenous route.When heated to decomposition it emits toxic fumes ofNOx.
Anthra[1,9-cd]pyrazol-6(2H)-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1H-Benz[6,7]indazol[2,3,4-fgh]naphth[2'',3'':6',7']indolo[3',2':5,6]anthra[2,1,9-mna]acridin-2,7,10,15-tetron
Anthra[2,1,9-mna]benz[6,7]indazolo[2,3,4-fgh]acridin-5,10-dion
1H-Benz[6,7]indazol[2,3,4-fgh]naphth[2'',3'':6',7']indolo[3',2':5,6]anthra[2,1,9-mna]acridin-2,7,10,15-tetron
Anthra[1,9-cd]pyrazol-6(2H)-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 221)Lieferanten
129-56-6(Anthra[1,9-cd]pyrazol-6(2H)-on)Verwandte Suche:
- Dibenzo[cd,g]indazol-6(2H)-one
- Nsc75890
- Wln: T C6665 1A p iv omnj
- SP600125 >99%
- JNK Inhibitor II, 1,9-Pyrazoloanthrone
- c.i.70300
- SAPK INHIBITOR I
- SAPK INHIBITOR II
- TIMTEC-BB SBB000595
- 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE
- InSolution&trade
- SP 600125, >=98%
- 2H-DIBENZO[CD,G]INDAZOL-6-ONE
- 1 9-PYRAZOLEANTHRONE
- 1,9-PYRAZOLOANTHRONE
- JNKII
- 1,9-Pyrazoloanthrone, Anthrapyrazolone
- JNK INHIBITOR II
- ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE
- ANTHRA-1,9-PYRAZOL-6-NONE
- ANTHRAPYRAZOLONE
- 3H-naphtho[2,3-f]indazol-3-one
- SP 600125;SP-600125;NSC75890
- JNK Inhibitor II - CAS 129-56-6 - Calbiochem
- SP 600125 - NSC 75890
- CS-548
- Anthra[1,9-cd]pyrazol-6(2H)-one >
- Anthra H
- 1PMV
- Supply Best Price and High Quality 1, 9-Pyrazoloanthrone CAS 129-56-6
- SP600125 (SP600125
- SP600125, ≥98% (HPLC)
- pyrazolanthrone
- SP600125
- Pyrazolanthrone (SP600125)
- JNK Inhibitor II SP600125 SP-600125
- SP600125/Pyrazolanthrone
- Pyrazoxanone
- 129-56-6
- C14H9N2O
- C14H8N2O
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- KETONE
- Kinase/Phosphatase Biology
- c-Jun N-Terminal Kinase (JNK)
- Serine/Threonine Kinase Inhibitors
- Other APIs
- MAPK
- Inhibitors
- Inhibitor
- Signalling
- Protein Kinase
