Colchicin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R26/28:Sehr giftig beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S13:Von Nahrungsmitteln, Getränken und Futtermitteln fernhalten.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Aussehen Eigenschaften
C22H25NO6, Colchicin für biochemische Zwecke. Colcemid (N-Deacetyl-N-methyl-colchicin)
Gefahren für Mensch und Umwelt
Zu vermeidende Stoffe: Oxidationsmittel.
Gefährliche Zersetzungsprodukte: Kohlenmonoxid, Kohlendioxid,
Stickoxide
Kann tödlich sein beim Verschlucken oder Einatmen.
LDL0 (oral, Mensch) 0,086 mg/kg.
Nach Verschlucken: Erbrechen, Durchfall, Lähmungen, Herz-Kreislaufstörungen; Tod. Nierenschädigung ist möglich.
Stark wassergefährdender Stoff (WGK 3). Substanz nicht in Gewässer, Abwasser oder Erdreich gelangen lassen.
Schutzmaßnahmen und Verhaltensregeln
Lagerung: dicht verschlossen, an gut belüftetem Ort, Nur für Sachkundige zugänglich.
Arbeiten nur im Abzug durchführen. Staub nicht einatmen.
Beim Auftreten von Stäuben Schutzmaske tragen.
Schutzbrille mit Seitenschutz und oberer Augenraumabdeckung
Chemikalienresistente Schutzhandschuhe (nur als kurzzeitiger Staubschutz)
Schutzkittel mit langen Ärmeln tragen.
Verhalten im Gefahrfall
Reinigungsverfahren: In einen Plastikbeutel aufnehmen und entsorgen. Staubbildung vermeiden. Betroffene Zone nach völliger Beseitigung des Materials gründlich lüften und reinigen.
Wassersprühstrahl, Kohlendioxid, Trockenlöschmittel oder geeigneter Schaum.
Im Falle eines Brandes entstehen gefährliche Dämpfe (NO
x).
Erste Hilfe
Nach Hautkontakt: Nach Berührung sofort mit Seife und viel Wasser abwaschen.
Nach Augenkontakt: 15 Minuten bei gespreizten Lidern unter fließendem Wasser mit Augendusche ausspülen. Augenarzt konsultieren!
Nach Einatmen: Nach Einatmen, Person sofort an die frische Luft bringen. Notarzt verständigen.
Nach Verschlucken: Reichlich Wasser trinken lassen, Erbrechen auslösen, Gabe von Aktivkohle (20-40g als 10%ige Aufschlämmung) und unverzüglich Arzt zu Rate ziehen.
Nach Kleidungskontakt: Verunreinigte Kleidung sofort ausziehen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
Falls Recycling nicht möglich, als Sonderabfall entsorgen, zuständige Stellen: Hubland-Herr Riepl:8884711, Klinikum-Herr Uhl:2015557.
Beschreibung
Colchicine is a pale-yellow powder that is obtained from various species of Colchicum, primarily Colchicum
autumnale L. Its total chemical synthesis has been achieved, but the primary source of colchicine currently remains alcohol
extraction of the alkaloid from the corm and seed of C. autumnale L. It darkens on exposure to light and possesses
Chemische Eigenschaften
Colchicine is a pale yellow powder. It has little or no odor. It darkens on contact with light.
Physikalische Eigenschaften
Appearance: colchicine exists in white or light-yellow crystal powder with no smell, and it is seldom prone to absorb moisture. Melting point: it becomes dark when it is exposed to light, and it melts at 87–89?°C. Solubility: this product is soluble in chloroform or ethanol and it dissolves in water. However, the semihydrate crystal can form in certain concentrations. The product is hardly soluble in ether. Specific optical rotation: ?121° (0.9?g/100?mL, chloroform, 589.3?nm, 17?°C).
History
Meadow saffron (Colchicum) is recorded to treat rheumatic swelling on ancient
Egyptian medical papyrus in 1500 B.C.. According to De Materia Medica written by Pedanius Dioscorides in the first century, extract of Meadow saffron is used
in treating gout. London Pharmacopoeia in 1618 recorded that colchicine is also
applied to treat gout.
In 1820, the ingredient was first isolated by the French chemist P.S. Pelletier and
J.B. Caventou. In 1833, it was purified and named by Geiger. Michael Dewar
guessed that there are two seven-membered rings in colchicine in 1945. Murray
Vernon King et al. determined the structure of colchicine by X-ray diffraction in
1952. In 1959, Albert Eschenmoser integrated the product successfully
Colchicine tablet and raw material are approved mostly in domestic in 2010. The
tablet produced by Taiwan manufacturers is approved for being listed in mainland
of China in 2012. The raw material made by Indian obtained the approval in 2013.
There are three kinds of colchicine approved by FDA: with the combination of probenecid, it is prior to be approved. The others are tablet (2009) and capsule (2014).
Verwenden
Colchicine is present in the poisonous autumncrocus (meadow saffron). It is the major alkaloid of Colchicum autumnale L. and Liliaceae. It was used in poison potions in theancient kingdom of Colchis (Greece). It isused therapeutically as an antineoplast, for thesuppression of gout, and in the treatment ofMediterranean fever. It is used in plant studiesfor doubling chromosome groups.
Definition
colchicine: An alkaloid derivedfrom the autumn crocus, Colchicumautumnale. It inhibits cell division.Colchicine is used in genetics, cytology,and plant breeding research andalso in cancer therapy to inhibit celldivision.
Indications
Colchicine, an alkaloid obtained from the autumn
crocus, has long been used and is relatively selective for
the treatment of acute gouty arthritis. Unlike many of
the newer agents for use in gout, colchicine has minimal
effects on uric acid synthesis and excretion; it decreases
inflammation associated with this disorder. It is thought
that colchicine somehow prevents the release of the
chemotactic factors and/or inflammatory cytokines from
the neutrophils, and this in turn decreases the attraction
of more neutrophils into the affected area .The
ability of colchicine to bind to leukocyte microtubules
in a reversible covalent complex and cause their depolymerization
also may be a factor in decreasing the
attraction of the motile leukocytes into the inflamed
area.
Biologische Funktion
Acting on
polymorphonuclear leukocytes and diminishing phagocytosis, it inhibits the production of lactic acid, causing an
increase in the pH of synovial tissue and, thus, a decrease in urate deposition, because uric acid is more soluble at
the higher pH. Additionally, colchicine inhibits the release of lysosomal enzymes during phagocytosis that also
contributes to the reduction of inflammation. Because colchicine does not lower serum urate levels, it has been found
to be beneficial to combine colchicine with a uricosuric agent, particularly probenecid. It is a potent drug, being
effective at doses of approximately 1 mg, but doses as small as 7 mg have caused fatalities.
Allgemeine Beschreibung
Colchicine is an alkaloid isolated from the dried corns andseeds of Colchicum autumnale L., commonly known as autumncrocus or meadow saffron.It is specifically indicated for acute treatment of goutyarthritis because of its ability to block the production and releaseof the CCF that mediates the inflammatory responsebecause of urate crystals, a mechanism different fromcolchicine’s antimitotic action, which is being investigatedfor its anticancer properties. It is often quite effective inaborting an acute gouty attack if given within the first 10 to12 hours after the onset of arthritis.
Air & Water Reaktionen
Slowly hydrolyzed in acidic solution, but unbuffered solutions are stable at 68°F for at least six months. Isomerizes on exposure to ultraviolet radiation.
Reaktivität anzeigen
Colchicine darkens on exposure to light. Incompatible with strong oxidizing agents. Also incompatible with mineral acids .
Hazard
As little as 20 mg may be fatal if ingested.
Health Hazard
Colchicine is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg, i.e. less than 7 drops for a 70 kg (150 lb.) person. Death results from respiratory arrest. The fatal dose varies considerably; as little as 7 mg of Colchicine has proved fatal.
Brandgefahr
Stable.
Biologische Aktivität
Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.
Mechanism of action
Colchicine is rapidly absorbed after oral administration
and tends to concentrate in the spleen, kidney,
liver, and gastrointestinal tract. Leukocytes also avidly
accumulate and store colchicine even after a single intravenous
injection. Since colchicine can accumulate in
cells against a concentration gradient, it is postulated
that an active transport process may be involved in its
cellular uptake. The drug is metabolized, primarily in
the liver, by deacetylation. Fecal excretion plays a major
role in colchicine elimination, since it and its metabolites
are readily secreted into the bile. Only about 15 to
30% of the drug is eliminated in the urine except in patients
with liver disease; urinary excretion is more important
in these individuals.
Pharmakokinetik
Colchicine is absorbed on oral administration, with peak plasma levels being attained within 0.5 to 2 hours after
dosing. Plasma protein binding is only 31%. It concentrates primarily in the intestinal tract, liver, kidney, and spleen
and is excreted primarily in the feces, with only 20% of an oral dose being excreted in the urine. It is retained in the
body for considerable periods of time, being detected in the urine and leukocytes for 9 to 10 days following a single
dose.
Pharmakologie
The drug
can be given intravenously as well as orally, but care
must be exercised, since extravasated drug may result in
local sloughing of skin and subcutaneous tissues. Relief
of pain and inflammation usually occurs within 48
hours. Small doses of colchicine can be used during
asymptomatic periods to minimize the reappearance or
severity of acute attacks. It should be used with caution
in patients with preexisting compromised heart, kidney,
gastrointestinal tract, and liver disease.
Diarrhea, nausea, vomiting, and abdominal pain are
the major limiting side effects that ultimately determine
the tolerated dosage. These symptoms occur in approximately
80% of patients who take colchicine, especially in those taking high dosages. The hepatobiliary recycling
of colchicine and its antimitotic effect on cells that
are rapidly turning over, such as those of the intestinal
epithelium, account for its gastrointestinal toxicity.
Gastrointestinal symptoms generally intervene before
the appearance of more serious toxicity and thereby
provide a margin of safety in drug administration.
Ingestion of large doses of colchicine may be followed
by a burning sensation in the throat, bloody diarrhea,
shock, hematuria, oliguria, and central nervous system
(CNS) depression.
Anticancer Research
It is a natural toxic secondary metabolite, extracted from Colchicum genus plants. Itprevents gastric cancer by upregulating the dual specificity phosphatase 1 (DUSP1)gene. It is also reported to upregulate transforming growth factor beta 2 (TGF-β2)and A-kinase anchoring protein 12 (AKAP12) in hepatocellular carcinoma (Singhet al. 2016b).
Clinical Use
The major use of colchicine is as an antiinflammatory
agent in the treatment of acute gouty arthritis; it is not effective
in reducing inflammation in other disorders. It also
can be used to prevent attacks. Since colchicine is so rapidly
effective in relieving the acute symptoms of gout
(substantial improvement is achieved within hours), it
has been used as a diagnostic aid in this disorder.
Therapy with colchicine is usually begun at the first
sign of an attack and is continued until symptoms subside,
adverse gastrointestinal reactions appear, or a
maximum dose of 6 to 7 mg has been reached.
Nebenwirkungen
Colchicine may produce bone marrow depression, with long-term therapy resulting in thrombocytopenia or aplastic
anemia. At maximum dose levels, GI disturbances (e.g., nausea, diarrhea, and abdominal pain) may occur. Acute
toxicity is characterized by GI distress, including severe diarrhea resulting in excessive fluid loss, respiratory
depression, and kidney damage. Treatment normally involves measures that prevent shock as well as morphine and
atropine to diminish abdominal pain. A number of drug interactions have been reported. In general, the actions of
colchicine are potentiated by alkalinizing substances and are inhibited by acidifying drugs, consistent with its
mechanism of action of increasing the pH of synovial fluid. Responses to CNS depressants and to sympathomimetic
drugs appear to be enhanced. Clinical tests may be affected; most notably, elevated alkaline phosphatase and SGOT
(serum glutamate oxaloacetate transaminase) values and decreased thrombocyte values may be obtained.
Sicherheitsprofil
experimentally by most routes. Human
systemic effects: aplastic anemia, blood
pressure depression, body temperature
decrease, changes in kidney tubules,
dyspnea, flaccid paralysis without anesthesia,
gastrointestinal effects, kidney damage and
hemorrhaging, muscle contraction or
spasticity, muscle weakness, nausea or
vomiting, respiratory stimulation, and
somnolence. An experimental teratogen.
Experimental reproductive effects. A severe
eye irritant. Human mutation data reported.
Inhibits the formation of microtubules and
thus impairs cell division. When heated to
decomposition it emits toxic fumes of NOx.
mögliche Exposition
Colchicine is a drug used to treat gouty arthritis, pseudogout, sarcoidal arthritis; and calcific tendonitis.
Environmental Fate
Colchicine binds to tubulin and prevents its polymerization
into microtubules, subsequently disrupting microtubule function.
Consequently, it alters nuclear structure, intracellular
transport, and cytoplasmic motility, ultimately causing cell
death. Colchicine is a potent inhibitor of cellular mitosis.
Stoffwechsel
Metabolism occurs primarily in the liver, with the major metabolite being the amine resulting from amide
hydrolysis.
Versand/Shipping
UN1544 Alkaloids, solid, n.o.s. or Alkaloid salts, solid, n.o.s. poisonous, Hazard Class: 6.1; Labels: 6.1- Poisonous materials, Technical Name Required. UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials
läuterung methode
Commercial material contains up to 4% desmethylcolchicine. Purify colchicine by chromatography on alumina and eluting with CHCl3 [Ashley & Harris J Chem Soc 677 1944]. Alternatively, an acetone solution on alkali-free alumina has been used, and eluting with acetone [Nicholls & Tarbell J Am Chem Soc 75 1104 1953]. It crystallises as yellow needles from EtOAc or CHCl3 with solvent of crystallisation which can be removed at ~70o. It is soluble in Et2O (0.5%), *C6H6 (1%) and H2O (4%). It is sold as “Colgout” for the treatment of gout and binds to tubulin. [Schreiber et al. Helv Chim Acta 44 540 1961, Scott et al. Tetrahedron 21 3605 1965, van Tamelen et al. Tetrahedron 14 8 1961, Beilstein 14 IV 946.]
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, mineral acids. Keep away from light.
Colchicin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Acetamide, N,N'-[(7S,7bR,8aS,8bS,9aR,10S,16cS,16dR,16eR,16fS)-5,6,7,7b,8,8a,8b,9,9a,10,11,12,16c,16d,16e,16f-hexadecahydro-1,2,3,8a,8b,14,15,16-octamethoxy-8,9-dioxobisbenzo[3',4']cyclohepta[1',2':3,4]cyclobuta[1,2-c:1',2'-c']cyclobuta[1,2-a:4,3-a']dicyclopentene-7,10-diyl]bis-
[7S-(7α,7bα,10aα)]-N-(5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamid
Thiocolchicin
