Methylisothiocyanat

Methyl isothiocyanate Struktur
556-61-6
CAS-Nr.
556-61-6
Bezeichnung:
Methylisothiocyanat
Englisch Name:
Methyl isothiocyanate
Synonyma:
MIT;isothiocyanatomethane;MIC;MENCS;CH3NCS;MITC;MTC;TRK;TRKA;NTRK1
CBNumber:
CB6455336
Summenformel:
C2H3NS
Molgewicht:
73.12
MOL-Datei:
556-61-6.mol

Methylisothiocyanat Eigenschaften

Schmelzpunkt:
30-34 °C(lit.)
Siedepunkt:
117-118 °C(lit.)
Dichte
1.069 g/mL at 25 °C(lit.)
Dampfdruck
21 mm Hg ( 20 °C)
Brechungsindex
nD37 1.5258
FEMA 
4426 | METHYL ISOTHIOCYANATE
Flammpunkt:
90 °F
storage temp. 
2-8°C
Löslichkeit
H2O: slightly soluble
Aggregatzustand
Low Melting Solid
Farbe
White to pale yellow
Geruch (Odor)
at 0.01 % in propylene glycol. pungent mustard horseradish
Geruchsart
pungent
Wasserlöslichkeit
7.6 g/L
Sensitive 
Moisture Sensitive
Merck 
14,6092
JECFA Number
1884
BRN 
605319
Stabilität:
Stable. Incompatible with strong oxidizing agents, alcohols, strong bases, amines.
InChIKey
LGDSHSYDSCRFAB-UHFFFAOYSA-N
LogP
1.3 at 20℃
CAS Datenbank
556-61-6(CAS DataBase Reference)
NIST chemische Informationen
Methane, isothiocyanato-(556-61-6)
EPA chemische Informationen
Methyl isothiocyanate (556-61-6)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,N
R-Sätze: 23/25-34-43-50/53
S-Sätze: 36/37-38-45-60-61
RIDADR  UN 2477 6.1/PG 1
WGK Germany  3
RTECS-Nr. PA9625000
21
TSCA  Yes
HazardClass  6.1
PackingGroup  I
HS Code  29309090
Giftige Stoffe Daten 556-61-6(Hazardous Substances Data)
Toxizität LD50 in rats, mice (mg/kg): 220, 110 orally; in rabbits (mg/kg): 33 dermally (Vernot); LD50 s.c. in mice: 0.05 g/kg (Klesse, Lukoschek)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H314 Verursacht schwere Verätzungen der Haut und schwere Augenschäden. Ätzwirkung auf die Haut Kategorie 1B Achtung P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P303+P361+P353 BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Methylisothiocyanat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/25:Giftig beim Einatmen und Verschlucken.
R34:Verursacht Verätzungen.
R43:Sensibilisierung durch Hautkontakt möglich.
R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

Beschreibung

Methyl iso thio cyanate is the organo sulfur compound with the formula CH3N = C = S . This low melting colorless solid is a powerful lachrymator. As a precursor to a variety of valuable bioactive compounds, it is the most important organic iso thio cyanate in industry.

Chemische Eigenschaften

Methyl isothiocyanate is a crystalline solid. Horseradish, acrid odor.

Occurrence

Reported found in horseradish.

Verwenden

Usually used to study the effect of pesticide Metam (methyl isothiocyanate is its active ingredient) in the streamside microbial communities of the upper Sacramento river

Definition

ChEBI: An isothiocyanate having a methyl group attached to the nitrogen.

Application

Solutions of MITC are used in agriculture as soil fumigants, mainly for protection against fungi and nematodes.
MITC is a building block for the synthesis of 1,3,4 - thiadiazoles, which are heterocyclic compounds used as herbicides. Commercial products include "Spike", "Ustilan," and "Erbotan." Well known pharmaceuticals prepared using MITC include Zantac and Tagamet.

Reaktionen

A characteristic reaction is with amines to give methyl thioureas:
CH3NCS + R2NH → R2NC(S)NHCH3
Other nucleophiles add similarly.

Allgemeine Beschreibung

A colorless liquid with a sharp odor. Lethal by inhalation of even small quantities of vapor. Does not have odor warning characteristics at low concentrations. Do not rely on the sense of smell to warn about the presence of vapors. Denser than water. Flash point below 20°F. May cause tearing and irritate the eyes, skin, nose and throat.

Air & Water Reaktionen

Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases.

Reaktivität anzeigen

Isocyanates and thioisocyanates, such as Methyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

Hazard

Toxic by ingestion, strong irritant to eyesand skin.

Health Hazard

Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg.

Brandgefahr

(Non-Specific -- Pesticide, Solid, n.o.s.) Methyl isothiocyanate may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated Methyl isothiocyanate emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks.

Sicherheit(Safety)

MITC is a dangerous lachrymator as well as being poisonous.

mögliche Exposition

It is used as a soil fumigant. A mixture of methyl isothiocyanate and chlorinated C-3 hydrocarbons is used as a soil fumigant for control of weeds, fungi, insects, and nematodes.

Environmental Fate

Soil. Though no products were reported, the reported half-life in soil is <14 days (Worthing and Hance, 1991).
Chemical/Physical. Emits toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Stoffwechselwegen

Methyl isothiocyanate is slowly decomposed in pure water, forming methylamine. It is metabolised in rats to the mercapturate via the glutathione conjugate which serves as a potential source of methyl isothiocyanate. Methyl isothiocyanate is reactive with cellular thiols and amines and its toxicity is associated with these reactions.

Versand/Shipping

UN2477 Methyl isothiocyanate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, Inhalation Hazard Zone B.

Inkompatibilitäten

Dust may form explosive mixture with air. Reacts with water, releasing carbon dioxide and methylamine gases. Unstable and reactive; sensitive to oxygen and to light. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, strong bases, amines, water, heat and cold. Attacks iron, zinc and other metals

Waste disposal

In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

Methylisothiocyanat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Methylisothiocyanat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 200)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 14770 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21703 55
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Jinan Finer Chemical Co., Ltd
+86-531-88989536 +86-15508631887
sales@finerchem.com China 2966 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845
sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47464 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29827 58

556-61-6(Methylisothiocyanat)Verwandte Suche:


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