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Diprophyllin Produkt Beschreibung

Diprophylline Struktur
479-18-5
CAS-Nr.
479-18-5
Bezeichnung:
Diprophyllin
Englisch Name:
Diprophylline
Synonyma:
Dilor;Theal;Airet;Dyflex;Neufil;Teofen;tesfen;circair;Circain;Coronal
CBNumber:
CB7177891
Summenformel:
C10H14N4O4
Molgewicht:
254.24
MOL-Datei:
479-18-5.mol

Diprophyllin Eigenschaften

Schmelzpunkt:
161-162 °C(lit.)
Siedepunkt:
397.46°C (rough estimate)
Dichte
1.3036 (rough estimate)
Brechungsindex
1.6200 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
Löslichkeit
Freely soluble in water, slightly soluble in ethanol (96 per cent).
Aggregatzustand
Powder
pka
13.74±0.20(Predicted)
Farbe
White
Wasserlöslichkeit
33 g/100 mL (25 ºC)
Merck 
14,3479
BRN 
284563
CAS Datenbank
479-18-5(CAS DataBase Reference)
NIST chemische Informationen
Dyphylline(479-18-5)
EPA chemische Informationen
Dyphylline (479-18-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 22-36/37/38
S-Sätze: 36-36/37-26
WGK Germany  3
RTECS-Nr. XH5100000
TSCA  Yes
HS Code  29395900
Giftige Stoffe Daten 479-18-5(Hazardous Substances Data)
Toxizität LD50 in mice (mg/kg): 3400 orally; 1430 s.c. (Al'tshuler)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P330 Mund ausspülen.

Diprophyllin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Beschreibung

Dyphylline is the N-7 dihydroxypropyl derivative of theophylline and is not a theophylline salt. Dyphylline does not get metabolized to theophylline in vivo, and even though it contains 70% theophylline by molecular weight ratio, the equivalent amount to theophylline is not known. Dosing must be accomplished independently by monitoring dyphylline blood levels. Dyphylline has a diminished bronchodilator effect compared to theophylline, but it may have lower and less serious side effects. Dosage forms available are an elixir and tablets.

Chemische Eigenschaften

white to light yellow crystal powder

Originator

Neothylline,Lemmon,US,1948

Verwenden

PDE inhibitor, bronchodilator, vasodilator

Definition

ChEBI: An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.

Manufacturing Process

180 grams of theophylline is dissolved in 500 cc of boiling water. To this solution is added 40 grams of sodium hydroxide or 56 grams of potassium hydroxide slowly and with constant stirring.
When solution is complete, 120 grams of 1-chloro-2,3-dihydroxypropane is slowly added. The thus provided mixture is brought to boiling and heating is continued until a temperature of 110°C is reached.
The resultant liquid is evaporated under reduced pressure to remove all traces of water. The resulting syrupy liquid is allowed to stand with occasional stirring until crystallization takes place. The compound is purified by recrystallization from alcohol. The product melts at 155°-157°C.

Trademarks

Dilor (Savage); Lufyllin (Medpointe); Neothylline (Teva).

Therapeutic Function

Smooth muscle relaxant

Diprophyllin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diprophyllin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 288)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20907 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Jimi Trading Co., Ltd.
+86 319 5273535
bestoneforyou@sina.com CHINA 292 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

479-18-5(Diprophyllin)Verwandte Suche:


  • 7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine
  • 1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-
  • 1h-purine-2,6-dione,7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl
  • 7-(2,3-Dihydroxypropyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
  • Circain
  • circair
  • component of Dilor g
  • component of Neothylline-gg
  • Coronal
  • Coronarin
  • Corphyllin
  • Cor-Theophylline
  • Dihydroxypropyl theophylline
  • Dihydroxypropyl theopylin
  • dihydroxypropyltheophylline
  • dihydroxypropyltheopylin
  • Dilor
  • Diprofillin
  • Diprofilline
  • diprophyllinee
  • Dipropylline
  • Droxine
  • Dyflex
  • Glyfyllin
  • Glyphyllin
  • Glyphylline
  • Hidroxiteofillina
  • Hiphyllin
  • Hyphylline
  • Iphyllin
  • Liactemin
  • Neophyl
  • Neophyllin
  • neophyllinm
  • neostenorasan
  • Neostenovasan
  • Neothylline
  • Neotilina
  • Neo-Vasophylline
  • Neufil
  • Neutrafil
  • Neutrafillina
  • Neutraphyllin
  • Neutraphylline
  • Neutroxantina
  • propylphyllin
  • Propyphyllin
  • Protheophylline
  • Purifilin
  • sibephyllin
  • sibephylline
  • Silbephyllin
  • Silbephylline
  • Solufilin
  • Solufyllin
  • Soluphyllin
  • Synthophylline
  • Tefilan
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