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Hydroxypropyl methyl cellulose Produkt Beschreibung

Hydroxypropyl methyl cellulose Struktur
9004-65-3
CAS-Nr.
9004-65-3
Englisch Name:
Hydroxypropyl methyl cellulose
Synonyma:
MHPC;HPMC;hpmcd;goniosol;HPMC/MHPC;methocelhg;HPMC /HEMC;isoptotears;isoptoplain;HYPROMELLOSE
CBNumber:
CB3225318
Summenformel:
C3H7O *
Molgewicht:
59.08708
MOL-Datei:
9004-65-3.mol

Hydroxypropyl methyl cellulose Eigenschaften

Dichte
1.39
Löslichkeit
H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow
Aggregatzustand
powder
Farbe
White to cream
Wasserlöslichkeit
SOLUBLE
Merck 
14,4842
Stabilität:
Stable. Solid is combustible, incompatible with strong oxidizing agents.
EPA chemische Informationen
Cellulose, 2-hydroxypropyl methyl ether(9004-65-3)

Sicherheit

S-Sätze: 24/25
WGK Germany  1
RTECS-Nr. NF9125000
3-10
TSCA  Yes
HS Code  39129000

Hydroxypropyl methyl cellulose Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Cellulose is a natural substance normally present in most diets because it is the major structural carbohydrate of green plants. Cellulose is essentially a linear polymer of glucopyranose units connected by (3-1,4-glucoside links. In nature, cellulose is present in plant cell walls as fibers. The molecular weight of isolated cellulose is approximately 50,000. The principal sources of cellulose for food related purposes are cotton linters and wood pulp. Chemical processing converts cellulose into forms or derivatives suitable for incorporation into food products, or for use in food packaging materials. Hydroxypropylmethyl cellulose is synthesized from methyl cellulose by the action of alkali and propylene oxide. The resultant product is a water soluble ether derivative of cellulose containing both methoxy and hydroxypropyl groups. The degree of substitution is 1.08 to 1.83 with the hydroxypropyl groups as the minor constituent. It is used as a thickening agent, stabilizer, and emulsifier.

Chemische Eigenschaften

white or slightly beige powder or a viscous solution

Chemische Eigenschaften

Hypromellose is an odorless and tasteless, white or creamy-white fibrous or granular powder.

Verwenden

Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Verwenden

A thickener for aqueous and non-aqueous systems.

Verwenden

As emulsifier, film former, protective colloid, stabilizer, suspending agent, or thickener in foods. Pharmaceutic aid (suspending agent; tablet excipient; demulcent; viscosity increasing agent); hydrophilic carrier in drug delivery systems. In adhesives, asphalt emulsions, caulking compounds, tile mortars, plastic mixes, cements, paints.

Verwenden

Hydroxypropyl Methylcellulose is a gum formed by the reaction of propylene oxide and methyl chloride with alkali cellulose. it will gel as the temperature is increased in heating and upon cooling will liquefy. the gel temperature ranges from 60°c to 90°c, forming semifirm to mushy gels. it is used in bakery goods, dressings, breaded foods, and salad dressing mix for syneresis control, texture, and to provide hot viscosity. usage level ranges from 0.05 to 1.0%.

Vorbereitung Methode

A purified form of cellulose, obtained from cotton linters or wood pulp, is reacted with sodium hydroxide solution to produce a swollen alkali cellulose that is chemically more reactive than untreated cellulose. The alkali cellulose is then treated with chloromethane and propylene oxide to produce methyl hydroxypropyl ethers of cellulose. The fibrous reaction product is then purified and ground to a fine, uniform powder or granules. Hypromellose can then be exposed to anhydrous hydrogen chloride to induce depolymerization, thus producing low viscosity grades.

Pharmazeutische Anwendungen

Hypromellose is widely used in oral, ophthalmic, nasal, and topical pharmaceutical formulations.
In oral products, hypromellose is primarily used as a tablet binder, in film-coating,and as a matrix for use in extendedrelease tablet formulations. Concentrations between 2% and 5% w/w may be used as a binder in either wet- or dry-granulation processes. High-viscosity grades may be used to retard the release of drugs from a matrix at levels of 10–80% w/w in tablets and capsules. Hypromellose is also used in liquid oral dosage forms as a suspending and/or thickening agent at concentrations ranging from 0.25–5.0%.
Depending upon the viscosity grade, concentrations of 2–20% w/w are used for film-forming solutions to film-coat tablets. Lowerviscosity grades are used in aqueous film-coating solutions, while higher-viscosity grades are used with organic solvents. Examples of film-coating materials that are commercially available include AnyCoat C, Spectracel, Pharmacoat, and the Methocel E Premium LV series. Hypromellose is also used as a suspending and thickening agent in topical formulations. Compared with methylcellulose, hypromellose produces aqueous solutions of greater clarity, with fewer undissolved fibers present, and is therefore preferred in formulations for ophthalmic use. Hypromellose at concentrations between 0.45–1.0% w/w may be added as a thickening agent to vehicles for eye drops and artificial tear solutions. It is also used commercially in liquid nasal formulations at a concentration of 0.1%. Hypromellose is used as an emulsifier, suspending agent, and stabilizing agent in topical gels and ointments. As a protective colloid, it can prevent droplets and particles from coalescing or agglomerating, thus inhibiting the formation of sediments. In addition, hypromellose is used in the manufacture of capsules, as an adhesive in plastic bandages, and as a wetting agent for hard contact lenses. It is also widely used in cosmetics and food products.

Sicherheit(Safety)

Hypromellose is widely used as an excipient in oral, opthalmic, nasal, and topical pharmaceutical formulations. It is also used extensively in cosmetics and food products.
Hypromellose is generally regarded as a nontoxic and nonirritating material, although excessive oral consumption may have a laxative effect. The WHO has not specified an acceptable daily intake for hypromellose since the levels consumed were not considered to represent a hazard to health. In fact, high dosages of hypromellose are being investigated for treating various metabolic syndromes.
LD50 (mouse, IP): 5 g/kg(20) LD50 (rat, IP): 5.2 g/kg

Lager

Hypromellose powder is a stable material, although it is hygroscopic after drying.
Solutions are stable at pH 3–11. Hypromellose undergoes a reversible sol–gel transformation upon heating and cooling, respectively. The gelation temperature is 50–90°C, depending upon the grade and concentration of material. For temperatures below the gelation temperature, viscosity of the solution decreases as temperature is increased. Beyond the gelation temperature, viscosity increases as temperature is increased.
Aqueous solutions are comparatively enzyme-resistant, providing good viscosity stability during long-term storage. However, aqueous solutions are liable to microbial spoilage and should be preserved with an antimicrobial preservative: when hypromellose is used as a viscosity-increasing agent in ophthalmic solutions, benzalkonium chloride is commonly used as the preservative. Aqueous solutions may also be sterilized by autoclaving; the coagulated polymer must be redispersed on cooling by shaking.
Hypromellose powder should be stored in a well-closed container, in a cool, dry place.

Inkompatibilitäten

Hypromellose is incompatible with some oxidizing agents. Since it is nonionic, hypromellose will not complex with metallic salts or ionic organics to form insoluble precipitates.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (ophthalmic and nasal preparations; oral capsules, suspensions, syrups, and tablets;topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Hydroxypropyl methyl cellulose Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Hydroxypropyl methyl cellulose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 273)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
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Jinan Finer Chemical Co., Ltd
+86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 943 58
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
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Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1019 58
Hangzhou Bayee Chemical Co., Ltd.
0086-571-86990109; 0086-18605816692
0086-571-85775919 rachelhoo@bayeechem.com China 98 55
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
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Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58

9004-65-3()Verwandte Suche:


  • hpmcd
  • hydroxylpropylmethylcellulose
  • Hydroxymethylpropylcellulose
  • isoptoalkaline
  • isoptoplain
  • isoptotears
  • methocele,f,k
  • HydroxypropylMethylCellulose(Hpmc)
  • HydroxyPropylMethylCelluloseHpmcE15Lv
  • HydroxyPropylMethylCelluloseHpmcE5LvPremium
  • Hydroxypropyl Methyl Cellulose (Mpmc), Cas
  • Methylcellulose, propylene glycol ether
  • Hydroxypropyl methyl cellulose, M.N. 86,000
  • viscosity 4,000 cP (2% solution)
  • HYDROXYPROPYLMETHYLCELLULOSE,100CPS,FCC
  • HYDROXYPROPYLMETHYLCELLULOSE,4,000CPS,FCC
  • HYDROXYPROPYLMETHYLCELLULOSE,50CPS,FCC
  • HYPROMELLOSE,2208,100,000CPS,USP
  • HYPROMELLOSE,2208,100CPS,USP
  • HYPROMELLOSE,2208,4,000CPS,USP
  • HYPROMELLOSE,2910,50CPS,USP
  • Hydroxyproxyl Cellulose
  • METHYLHYDROXYPROPYLCELLULOSE
  • PROPYLENEGLYCOLMETHYLCELLULOSE
  • HYDROXPROPYLMETHYLCELLULOSE
  • HYDROXYPROPYLMETHYLCELLULOSEGEL
  • High-Substituted Hydroxyproxyl Cellulose
  • MHPC
  • HYDROXYPROPYL METHYL CELLULOSE (HPMC) (13.0-18.0 M
  • HYDROXYPROPYL METHYL CELLULOSE (HPMC) (3.0-7.0 MPA
  • HYDROXYPROPYL METHYL CELLULOSE (HPMC) (40.0-60.0 M
  • HYDROXYPROPYL METHYL CELLULOSE (HPMC) (8.0-12.0 MP
  • Hydroxypropyl Methyl cellulose USP
  • (Hydroxypropyl)Methyl cellulose average Mn ~10,000
  • (Hydroxypropyl)Methyl cellulose average Mn ~86,000
  • (Hydroxypropyl)methyl cellulose average Mn ~120,000
  • (Hydroxypropyl)methyl cellulose average Mn ~90,000
  • (HYDROXYPROPYL)METHYL CELLULOSE, 15
  • HYDROXYPROPYLMETHYLCELLULOSE 2910, U
  • HYDROXYPROPYLMETHYLCELLULOSE APPROX*
  • Hydroxypropyl methylcellulose, 28 to 30% methoxyl, 7 to 12% hydroxypropyl, viscosity (2% aq. soln., 20°C) 7500 to 14000mPa.s
  • Methocel K 15
  • Manufacturers Wholesale Hydroxypropyl methyl cellulose CAS NO.9004-65-3
  • New product Hydroxypropyl Methyl Cellulose ether (HPMC) with best price and good quality
  • white powder HPMC for building materials
  • Methocel K 15(Hydroxypropyl methyl cellulose)
  • best price white powder HPMC
  • HPMC Hydroxypropyl Methyl Cellulose cas 9004-65-3
  • HPMC, High viscosity hydroxypropylmethylcellulose
  • HPMC, Low viscosity hydroxypropylmethylcellulose
  • HPMC, Medium viscosity hydroxypropylmethylcellulose
  • MODIFIED CELLULOSE
  • PROPYLENE GLYCOL ETHER OF METHYLCELLULOSE
  • HPMC
  • HYPOMELLOSE 2208
  • HYPOMELLOSE 2906
  • HYPOMELLOSE 2910
  • HYPROMELLOSE
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