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o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat Produkt Beschreibung

Nitazoxanide Struktur
55981-09-4
CAS-Nr.
55981-09-4
Bezeichnung:
o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat
Englisch Name:
Nitazoxanide
Synonyma:
BRN 1225475;nitazoxamide;NITAZOXANIDE;AURORA KA-645;Nitazoxanide API;Nitazoxanide (200 mg);Nitazoxanide(Alinia, Annita);2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide;2-(acetyloxy)-n-(5-nitro-2-thiazolyl)-benzamid;2-(acetolyloxy)-n-(5-nitro-2-thiazolyl)benzamide
CBNumber:
CB7219063
Summenformel:
C12H9N3O5S
Molgewicht:
307.28
MOL-Datei:
55981-09-4.mol

o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat Eigenschaften

Schmelzpunkt:
202°C
Dichte
1.629 g/cm3
storage temp. 
-20°C Freezer
pka
6.18±0.50(Predicted)
maximale Wellenlänge (λmax)
416nm(Phosphate buffer sol.)(lit.)
Merck 
14,6567
CAS Datenbank
55981-09-4(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22-36/37/38
S-Sätze: 26-36
WGK Germany  3
RTECS-Nr. VN7830000
HS Code  2934100000
Toxizität LD50 orally in male, female mice: 1350, 1380 mg/kg; in rats: >10 g/kg (Murphy, Friedmann)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Crystalline Solid

Verwenden

An anthelmintic (cestodes), antiprotozoal (cryptosporidium). Kills Mycobacterium tuberculosis.

Verwenden

antihypertensive

Verwenden

For the treatment of diarrhea in adults and children caused by the protozoa Giardia lamblia and for the treatment of diarrhea in children caused by the protozoa Cryptosporidium parvum.

Trademarks

Alinia (Romark).

Antimicrobial activity

In vitro Cryptosporidium parvum sporocytes and oocysts are inhibited by <33 μm, and Giardia lamblia (intestinalis) trophozoites by <10 μm. The metabolite tizoxanide is more active than the parent compound against some isolates. E. histolytica is inhibited by 6–23 μm (parent compound) and 5.6– 28 μm (metabolite), and T. vaginalis by 0.5–15.5 μm (parent compound) and 0.3–12.2 μm (metabolite). Activity against other micro- organisms, including some helminths, bacteria (Clostridium difficile) and viruses (hepatitis C) has also been demonstrated.

Acquired resistance

Resistance caused by altered expression of genes involved in stress response has been demonstrated in experimental studies with G. lamblia.

Pharmazeutische Anwendungen

A synthetic broad-spectrum antiparasitic nitroheterocycle (2-acetyloxy- N-(5-nitro-2-thiazolyl) benzamide), formulated for oral use.

Pharmakokinetik

After oral administration the major circulating metabolites are tizoxanide (desacetyl nitazoxanide) and its glucuronide. Minor metabolites include salicyluric acid and tizoxanide sulfate. Maximum concentrations of the active metabolites tizoxanide and tizoxanide glucuronide are observed within 1–4 h. Following a single oral dose of 500 mg given with food, the Cmax of both metabolites was around 10 mg/L. Tizoxanide has a halflife of around 1–2 h and is >99.9% bound to plasma proteins.

Clinical Use

It is indicated for the treatment of diarrhea caused by G. lamblia or C. parvum.

Nebenwirkungen

Nitazoxanide appears well tolerated. Side effects may include abdominal pain diarrhea, headache and nausea.

Veterinary Drugs and Treatments

Nitazoxanide oral paste is indicated for the treatment of horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
In humans, nitazoxanide is approved (in the USA) for use in treating diarrhea caused by Cryptosporidium parvum and Giardia lamblia in pediatric patients from ages 1 to 11 years old.
Because of the drug’s spectrum of activity and apparent safety, there is considerable interest in using it in a variety of companion animal species, but data is lacking for specific indications and dosages.

o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 212)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
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0755-23311925 Abel@chembj.com CHINA 3194 55
Beijing Cooperate Pharmaceutical Co.,Ltd.
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+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
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+86-0592-6210733 sale@mainchem.com CHINA 32447 55
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86-0551-65418684 info@tnjchem.com China 1861 55
career henan chemical co
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sales@coreychem.com CHINA 30001 58
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Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58

55981-09-4(o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat)Verwandte Suche:


  • n-(5-nitro-2-thiazolyl)-salicylamidacetate(ester)
  • n-(5-nitro-2-thiazolyl)salicylamideacetate(ester)
  • AURORA KA-645
  • o-[n-(5-nitrothiazol-2-yl)carbamoyl]phenyl acetate
  • NITAZOXANIDE
  • nitazoxamide
  • PH-5776, Cryptaz, 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
  • 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
  • [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate
  • [2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] ethanoate
  • acetic acid [2-[(5-nitrothiazol-2-yl)carbamoyl]phenyl] ester
  • Nitazoxanide (200 mg)
  • Nitazoxanide(Alinia, Annita)
  • Nitazoxanide API
  • 2-((5-nitrothiazol-2-yl)carbaMoyl)phenyl acetate
  • Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-
  • 2-(acetolyloxy)-n-(5-nitro-2-thiazolyl)benzamide
  • 2-(acetyloxy)-n-(5-nitro-2-thiazolyl)-benzamid
  • BRN 1225475
  • 55981-09-4
  • C12H9N3O5S
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Heterocycles
  • Sulfur & Selenium Compounds
  • API
  • Isotope labeled API
  • ENDURON
  • Pyridines
  • -
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