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Nitazoxanide 구조식 이미지
카스 번호:
BRN 1225475;nitazoxamide;NITAZOXANIDE;AURORA KA-645;Nitazoxanide API;Nitazoxanide (200 mg);Nitazoxanide(Alinia, Annita);2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide;2-(acetyloxy)-n-(5-nitro-2-thiazolyl)-benzamid;2-(acetolyloxy)-n-(5-nitro-2-thiazolyl)benzamide
포뮬러 무게:
MOL 파일:

Nitazoxanide 속성

저장 조건
-20°C Freezer
최대 파장(λmax)
416nm(Phosphate buffer sol.)(lit.)
CAS 데이터베이스
55981-09-4(CAS DataBase Reference)
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 22-36/37/38
안전지침서 26-36
WGK 독일 3
RTECS 번호 VN7830000
HS 번호 2934100000
독성 LD50 orally in male, female mice: 1350, 1380 mg/kg; in rats: >10 g/kg (Murphy, Friedmann)
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

Nitazoxanide C화학적 특성, 용도, 생산

화학적 성질

Crystalline Solid


An anthelmintic (cestodes), antiprotozoal (cryptosporidium). Kills Mycobacterium tuberculosis.




For the treatment of diarrhea in adults and children caused by the protozoa Giardia lamblia and for the treatment of diarrhea in children caused by the protozoa Cryptosporidium parvum.


Alinia (Romark).

Antimicrobial activity

In vitro Cryptosporidium parvum sporocytes and oocysts are inhibited by <33 μm, and Giardia lamblia (intestinalis) trophozoites by <10 μm. The metabolite tizoxanide is more active than the parent compound against some isolates. E. histolytica is inhibited by 6–23 μm (parent compound) and 5.6– 28 μm (metabolite), and T. vaginalis by 0.5–15.5 μm (parent compound) and 0.3–12.2 μm (metabolite). Activity against other micro- organisms, including some helminths, bacteria (Clostridium difficile) and viruses (hepatitis C) has also been demonstrated.


Resistance caused by altered expression of genes involved in stress response has been demonstrated in experimental studies with G. lamblia.

Pharmaceutical Applications

A synthetic broad-spectrum antiparasitic nitroheterocycle (2-acetyloxy- N-(5-nitro-2-thiazolyl) benzamide), formulated for oral use.


After oral administration the major circulating metabolites are tizoxanide (desacetyl nitazoxanide) and its glucuronide. Minor metabolites include salicyluric acid and tizoxanide sulfate. Maximum concentrations of the active metabolites tizoxanide and tizoxanide glucuronide are observed within 1–4 h. Following a single oral dose of 500 mg given with food, the Cmax of both metabolites was around 10 mg/L. Tizoxanide has a halflife of around 1–2 h and is >99.9% bound to plasma proteins.

Clinical Use

It is indicated for the treatment of diarrhea caused by G. lamblia or C. parvum.


Nitazoxanide appears well tolerated. Side effects may include abdominal pain diarrhea, headache and nausea.

Veterinary Drugs and Treatments

Nitazoxanide oral paste is indicated for the treatment of horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
In humans, nitazoxanide is approved (in the USA) for use in treating diarrhea caused by Cryptosporidium parvum and Giardia lamblia in pediatric patients from ages 1 to 11 years old.
Because of the drug’s spectrum of activity and apparent safety, there is considerable interest in using it in a variety of companion animal species, but data is lacking for specific indications and dosages.

Nitazoxanide 준비 용품 및 원자재


준비 용품

Nitazoxanide 공급 업체

글로벌( 201)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3194 55
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 CHINA 1817 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1852 55
career henan chemical co
+86-371-86658258 CHINA 27142 58
0086-13720134139 CHINA 955 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23967 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 8260 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651 CHINA 2299 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6370 58

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