ChemicalBook
Chinese english Germany Japanese Korea

Atosiban Produkt Beschreibung

Atosiban Struktur
90779-69-4
CAS-Nr.
90779-69-4
Englisch Name:
Atosiban
Synonyma:
Atosiban;rwj22164;Human Atosiban;Atosiban, >=98%;ATOSIBAN ACETATE;Oxytropis Falcata;Atosiban Impurtiy;Atosiban, RWJ 22164;Atosiban impurity 1;AtosibanAcetate(Tractocile)
CBNumber:
CB7497854
Summenformel:
C45H71N11O14S2
Molgewicht:
994.19
MOL-Datei:
90779-69-4.mol

Atosiban Eigenschaften

storage temp. 
−20°C
Löslichkeit
H2O: ≤100 mg/mL
Aggregatzustand
solid
CAS Datenbank
90779-69-4(CAS DataBase Reference)

Sicherheit

WGK Germany  3
RTECS-Nr. RS7590000

Atosiban Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.

Originator

Ferring AB (Sweden)

Verwenden

Premature labor

Verwenden

Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.

Indications

Atosiban is an analogue of oxytocin that is modified at positions 1, 2, 4, and 8. It is a competitive inhibitor of oxytocin binding. Early studies have demonstrated that this drug does decrease and stop uterine contractions. Atosiban is not available for use in the United States.

Trademarks

Tractocile, Antocin

Anticancer Research

The antitumor effects of the essential oil of O. falcata were tested in transplantedmurine H22 solid tumors in vivo. Growth inhibition in H22 solid tumors was moderate(Yang et al. 2013).

Atosiban Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Atosiban Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 159)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21672 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30003 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2258 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 913 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4001 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3030 58

90779-69-4()Verwandte Suche:


  • 1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin
  • oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l
  • rwj22164
  • Atosiban Impurtiy
  • ATOSIBAN ACETATE
  • 1-(3-Mercaptopropionic acid)-2-(3-(p-ethoxyphenyl)-D-alanine)-4-L-thre onine-8-L-ornithineoxytocin
  • [Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys]-Pro-Orn-Gly-NH2
  • (2S)-N-[(1S)-4-Amino-1-(carbamoylmethylcarbamoyl)butyl]-1-[(4S,7S,13S,16R)-13-[(2S)-butan-2-yl]-7-(carbamoylmethyl)-16-[(4-ethoxyphenyl)methyl]-10-(1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
  • 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
  • 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin
  • Atosiban
  • Human Atosiban
  • 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile, 1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin
  • Atosiban,1-(3-Mercaptopropanoic acid)-2-(O-ethyl-D-tyrosine)-4-L-threonine-8-L-ornithineoxytocin, 1-Deamino-2-D-Tyr-(O-ethyl)-4-Thr-8-ornoxytocin, Tractocile
  • Atosiban, RWJ 22164
  • Oxytropis Falcata
  • AtosibanAcetate(Tractocile)
  • 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 (Disulfide bond)
  • Atosiban impurity 1
  • Atosiban, >=98%
  • (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin, Atosiban
  • 1-({(4r,7s,13s,16r)-7-(2-amino-2-oxoethyl)-13-[(2s)-butan-2-yl]-16-(4-ethoxybenzyl)-10-[(1r)-1-hydroxyethyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-l-prolyl-l-ornithylglycinamide
  • 90779-69-4
  • C45H71N11O14S2
  • C43H67N11O12S2
  • Peptide
  • hormones
Copyright 2019 © ChemicalBook. All rights reserved