ChemicalBook
Chinese English Japanese Germany Korea

Atosiban

Atosiban 구조식 이미지
카스 번호:
90779-69-4
상품명:
Atosiban
동의어(영문):
Atosiban;rwj22164;Human Atosiban;Atosiban, >=98%;ATOSIBAN ACETATE;Oxytropis Falcata;Atosiban Impurtiy;Atosiban, RWJ 22164;Atosiban impurity 1;AtosibanAcetate(Tractocile)
CBNumber:
CB7497854
분자식:
C45H71N11O14S2
포뮬러 무게:
994.19
MOL 파일:
90779-69-4.mol

Atosiban 속성

저장 조건
−20°C
용해도
H2O: ≤100 mg/mL
물리적 상태
solid
CAS 데이터베이스
90779-69-4(CAS DataBase Reference)

안전

WGK 독일 3
RTECS 번호 RS7590000

Atosiban C화학적 특성, 용도, 생산

개요

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.

Originator

Ferring AB (Sweden)

용도

Premature labor

용도

Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.

Indications

Atosiban is an analogue of oxytocin that is modified at positions 1, 2, 4, and 8. It is a competitive inhibitor of oxytocin binding. Early studies have demonstrated that this drug does decrease and stop uterine contractions. Atosiban is not available for use in the United States.

상표명

Tractocile, Antocin

Anticancer Research

The antitumor effects of the essential oil of O. falcata were tested in transplantedmurine H22 solid tumors in vivo. Growth inhibition in H22 solid tumors was moderate(Yang et al. 2013).

Atosiban 준비 용품 및 원자재

원자재

준비 용품


Atosiban 공급 업체

글로벌( 150)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21956 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 3911 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23959 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 1510 58
Creative Peptides
info@creative-peptides.com United States 6249 56

Copyright 2019 © ChemicalBook. All rights reserved