Nefazodone hydrochloride
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- CAS-Nr.
- 82752-99-6
- Englisch Name:
- Nefazodone hydrochloride
- Synonyma:
- TFA ≥Serazone;NEFAZODONE;Indole ≥Isatin ≥BMY 13754-1;Hecameg ≥>=98% (HPLC);Chromone ≥Piperine &ge
- CBNumber:
- CB8144863
- Summenformel:
- C25H33Cl2N5O2
- Molgewicht:
- 506.47
- MOL-Datei:
- 82752-99-6.mol
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Nefazodone hydrochloride Eigenschaften
- Schmelzpunkt:
- 186-188°C
- storage temp.
- Inert atmosphere,Room Temperature
- Löslichkeit
- DMSO: ~11 mg/mL at 60 °C
- Aggregatzustand
- solid
- Farbe
- white
- maximale Wellenlänge (λmax)
- 248nm(MeOH)(lit.)
- Merck
- 14,6438
- CAS Datenbank
- 82752-99-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
22-24/25 |
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| RIDADR |
UN1230 - class 3 - PG 2 - Methanol, solution |
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| WGK Germany |
3 |
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| RTECS-Nr. |
XZ5483009 |
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| HS Code |
2933595960 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Nefazodone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Nefazodone, a second generation trazodone type antidepressant, was launched in Canada. Nefazodone acts as both a potent 5-HT
2 receptor antagonist
and as a serotonin (5-HT) reuptake inhibitor. This combination effect appears to
enhance 5-HT
IA-mediated neurotransmission. Distinct from the first generation
agents such as tricyclic antidepressants, nefazodone has very selective
serotonergic effects with negligible affinity for cholinergic and histamine receptors,
and low affinity for a
1 -adrenergic receptors. Therefore, it has a superior toxicity
profile that does not produce agitation, insomnia, and lacks cardiac side effects.
Chemische Eigenschaften
White Solid
Verwenden
A selective serotonin 5-HT2 receptor antagonist. A novel antidepressant that shows no cardiac toxicity or anticholinergic activity common with tricyclic antidepressants.
Allgemeine Beschreibung
Nefazodone, formerly sold under the brand names Serzone, Dutonin, and Nefadar, is an antidepressant that has been discontinued due to the incidence of severe liver damage. This certified Snap-N-Spike
; solution is suitable for use as a starting material in calibrators and controls for numerous GC/MS or LC/MS applications in forensic analysis, clinical toxicology and urine drug testing.
Biologische Aktivität
Serotonin 5-HT 2A receptor antagonist (K i = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC 50 values are 290 and 300 nM respectively). Displays no activity at 5-HT 1B and 5-HT 1D receptors. Active in models predictive of antidepressant potential.
Nefazodone hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nefazodone hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 205)Lieferanten
82752-99-6()Verwandte Suche:
- NEFAZODONE-D5 HCL
- 3H-1,2,4-Triazol-3-one, 2-3-4-(3-chlorophenyl)-1-piperazinylpropyl-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-, monohydrochloride
- Nefazodone HCl
- Nefazodone hydrochloride
- NEFAZODONE
- BMY-13754, MJ-13754-1, Serzone, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
- 2,4-Dihydro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-5-ethyl-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride
- Nefazodone Hydrochloride (200 mg)
- 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one
- BMY 13754-1
- Serazone
- Nefazodone hydrochloride API
- 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-one hydrochloride
- Nefazodone hydrochlo
- 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4H)-
- >=98% (HPLC)
- 1-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-3-ethyl-4-(2-phenoxyethyl)-1H-1,2,4-triazol-5(4
- )-trans-4-(3-cyanophenyl)pyrrolidine-3-carboxylic acid &ge
- 3-[(3-Cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate &ge
- Na-Fmoc-Nb-(N-Boc-amino-oxyacetyl)-L-2,3-diaminopropionic acid &ge
- Fmoc-1-amino-4-oxo-cyclohexane carboxylic acid &ge
- 8-Methoxy-1H-benzo[d][1,3]oxazine-2,4-dione &ge
- Fmoc-D-2-amino-4-bromo-4-pentenoic acid &ge
- 2-Amino-5-(4-fluorophenyl)-1,3,4-thiadiazole &ge
- 3-(4-Methoxyphenyl)pyrazole &ge
- Boc-N-ethyl glycine &ge
- Boc-D-a-aminobutyric acid &ge
- Na-Fmoc-Ne-Z-L-lysine &ge
- (1,2-Dibromoethyl)benzene &ge
- Na-Acetyl-L-ornithine &ge
- Na-Acetyl-D-tryptophan &ge
- 5,6-Dimethoxyindole &ge
- Z-L-serine amide &ge
- TFA &ge
- Gly-OBg·
- Boc-4-iodo-L-phenylalanine &ge
- Boc-S-tert-butyl-L-cysteine dicyclohexylammonium salt &ge
- D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid &ge
- (3R)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester hydrochloride &ge
- 4-Acetamido-2-methylbenzoic acid &ge
- Methyl 2,4-dioxo-4-(2-thienyl)butanoate &ge
- 3-(4-Fluorophenyl)-1H-pyrazole-5-carbohydrazide &ge
- (3-Benzothienyl)-L-b-homoalanine hydrochloride &ge
- 2-(2H-Tetrazol-5-yl)pyridine &ge
- (S)-Fmoc-3-amino-2-benzyl-propionic acid &ge
- 7-Methoxy-1H-indole-3-carbaldehyde &ge
- 2-Chloro-6-methyl-4-(trifluoromethyl)pyridine &ge
- 5-Amino-2-methylpyridine &ge
- Ethyl 3-Amino-3-ethoxyacrylate hydrochloride &ge
- Fmoc-(4-aminomethyl) benzoic acid &ge
- Fmoc-3,4-dichloro-L-b-homophenylalanine &ge
- 1,3-Diacetylindole &ge
- Fmoc-3-nitro-D-phenylalanine &ge
- 4-Amino-D-phenylalanine hydrochloride &ge
- Fmoc-(R)-4-aminopimelic acid 1-tert-butyl ester &ge
- 5-Azacytidine &ge
- 1-(2-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbohydrazide &ge
- 5-(4-Bromophenyl)thiophene-2-carboxylic acid &ge
