4,4'-Methylenbis[3-hydroxy-2-naphthoe]sure, Verbindung mit (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidin (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Pale yellow or yellow powder.
Verwenden
An antiparasitic agent used in the treatment of intestinal parasites such as hookworms and roundworms (Ascaris lumbricoides, aka ascarids in humans) in domesticated animals such as horses, cattle, sheep, pigs, cats, dogs, and many other species.
Indications
Pyrantel pamoate (Antiminth) is a agonist at the nicotinic
acetylcholine receptor, and its actions result in depolarization
and spastic paralysis of the helminth muscle.
Its selective toxicity occurs primarily because the
neuromuscular junction of helminth muscle is more
sensitive to the drug than is mammalian muscle. This
drug is administered orally, and because very little is absorbed,
high levels are achieved in the intestinal tract.
Less than 15% of the drug and its metabolites are excreted
in urine.
Allgemeine Beschreibung
Odorless light yellow to tan crystalline powder. Tasteless. Used medicinally against nematodes in animals.
Air & Water Reaktionen
May be sensitive to prolonged exposure to air and light . Insoluble in water.
Reaktivität anzeigen
Pyrantel pamoate may react with acids to liberate heat. May react exothermically enough with strong oxidizing acids to ignite the reaction products. Heat is also generated with caustic solutions. Generates flammable or toxic gases with alkali metals and hydrides and other reducing agents.
Brandgefahr
Flash point data for Pyrantel pamoate are not available; however, Pyrantel pamoate is probably combustible.
Clinical Use
Trans-1,4,5,6,-Tetrahydro-1-methyl-2-[2-(2 -thienyl)ethenyl]pyrimidine pamoate (Antiminth) is a depolarizing neuromuscularblocking agent that causes spastic paralysis insusceptible helminths. It is used in the treatment of infestationscaused by pinworms and roundworms (ascariasis).Because its action opposes that of piperazine, the twoanthelmintics should not be used together. More than halfof the oral dose is excreted in the feces unchanged.Adverse effects associated with its use are primarilygastrointestinal.
Nebenwirkungen
Pyrantel pamoate is active against several roundworms:
A. lumbricoides, Ancylostoma duodenale, Necator
americanus, and E. vermicularis. Pyrantel is an alternative
drug of choice in treating infections with A. lumbricoides,
E. vermicularis (pinworms), and hookworms
(N. americanus and A. duodenale). It is not recommended
for pregnant patients or for children under age
1 year.
Although most of the drug remains in the intestinal
lumen, enough can be absorbed systemically to cause
headache, dizziness, and drowsiness. No major adverse
effects have been reported on renal, hepatic, or hematological
systems.
4,4'-Methylenbis[3-hydroxy-2-naphthoe]sure, Verbindung mit (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]pyrimidin (1:1) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
