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D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1) Produkt Beschreibung

Chlorhexidine digluconate Struktur
18472-51-0
CAS-Nr.
18472-51-0
Bezeichnung:
D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1)
Englisch Name:
Chlorhexidine digluconate
Synonyma:
abacil;D00858;uconate;septeal;unisept;d-)(2:1;hibidil;placout;corsodyl;disteryl
CBNumber:
CB9702888
Summenformel:
C34H54Cl2N10O14
Molgewicht:
897.76
MOL-Datei:
18472-51-0.mol

D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1) Eigenschaften

Dichte
1.06 g/mL at 25 °C(lit.)
storage temp. 
2-8°C
Löslichkeit
water: soluble50% (w/v)
Aggregatzustand
Liquid
Farbe
Colorless
Sensitive 
Light Sensitive
maximale Wellenlänge (λmax)
257nm(H2O)(lit.)
Merck 
14,2091
InChIKey
YZIYKJHYYHPJIB-UUPCJSQJSA-N
CAS Datenbank
18472-51-0(CAS DataBase Reference)
EPA chemische Informationen
Chlorhexidine gluconate (18472-51-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher N
R-Sätze: 50/53
S-Sätze: 61
RIDADR  UN 3082 9 / PGIII
WGK Germany  -
RTECS-Nr. DU1950000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29252900
Toxizität LD50 in mice (mg/kg): 22 i.v.; 1800 orally (Foulkes)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
H410 Sehr giftig für Wasserorganismen mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
H411 Giftig für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 2
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P391 Verschüttete Mengen aufnehmen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

Chemische Eigenschaften

Almost colourless or pale-yellowish liquid.

Verwenden

chlorhexidine digluconate is a preservative generally used in concentrations of 0.01 to 0.1 percent to protect against bacteria. It is unstable at high temperatures. Chlorhexidine digluconate is more widely used in europe than in the united States.

Verwenden

Hydrogenolysis of benzyl-nitrogen bonds

Verwenden

Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. It is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.

Trademarks

Dyna-Hex (Xttrium); Hibiclens (Regent); Peridex (Zila); Periochip (Dexcel); Periogard (Colgate); Prevacare (Johnson & Johnson).

Clinical Use

1,6-Di(4 -chlorophenyldiguanido)hexane gluconate (Hibiclens)is the most effective of a series of antibacterial biguanides originallydeveloped in Great Britain.
The antimicrobial properties of the biguanides were discoveredas a result of earlier testing of these compounds aspossible antimalarial agents. Although thebiguanides are technically not bisquaternary ammoniumcompounds and, therefore, should probably be classifiedseparately, they share many physical, chemical, and antimicrobialproperties with the cationic surfactants. Thebiguanides are strongly basic, and they exist as dications atphysiological pH. In chlorhexidine, the positive charges arecounterbalanced by gluconate anions (not shown). Likecationic surfactants, these undergo inactivation when mixedwith anionic detergents and complex anions such as phosphate,carbonate, and silicate.
Chlorhexidine has broad-spectrum antibacterial activitybut is not active against acid-fast bacteria, spores, orviruses. It has been used for such topical uses as preoperativeskin disinfection, wound irrigation, mouthwashes, andgeneral sanitization. Chlorhexidine is not absorbedthrough skin or mucous membranes and does not causesystemic toxicity.

D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 321)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-15319487004
+86-29-88380327 1015@dideu.com CHINA 1987 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Panjin Jiahe Shengshi Medical Technology Co., Ltd.
0427-6572122
0427-6572122 jiahe@jhssw.com CHINA 4 55
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 14164 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21806 58
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3159 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24697 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2368 55
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 296 58

18472-51-0(D-Gluconsure, Verbindung mit N,N''-Bis(4-chlorphenyl)-3,12-diimino-2,4,11,13-tetraazatetradecandiamidin (2:1))Verwandte Suche:


  • orhexidine dig
  • uconate
  • Chlorhexidine Digluconate (20% in Water)
  • CHLORHEXIDINE GLUCONATE 20% SOLUTION
  • CHLORHEXADINE GLUCONATE 20%
  • CHLORHEXIDINE DIGLUCONATE 20% AQUEOU
  • Chlorhexidine digluconate, Non-sterile
  • D-Digluconate
  • Glucose acid chloride
  • .alpha.-Cymen-5-ol
  • 1,1’-hexamethylenebis(5-(p-chlorophenyl)-biguaniddigluconate
  • 1,6-bis(5-(p-chlorophenyl)biguandino)hexanedigluconate
  • 3-Methyl-4-(1-methylethyl)phenol
  • abacil
  • arlacideg
  • bacticlens
  • caswellno.481g
  • chlorhexidinedi-d-gluconate
  • chlorhexidinedigluconate20%aqueous*solution
  • chlorhexidinglukonatu
  • septeal
  • tetraazatetradecanediimidamide(2:1)
  • unisept
  • CHLORHEXIDINE GLUCONATE
  • CHLORHEXIDINE DIGLUCONATE
  • 1,1'-HEXAMETHYLENEBIS[5-(P-CHLOROPHENYL)BIGUANIDE]) DIGLUCONATE
  • 1,6-BIS[N5-(P-CHLOROPHENYL)-N1-BIGUANIDO]HEXANE DIGLUCONATE
  • 1,6-DI(N-P-CHLOROPHENYL-DIGUANIDO) HEXANE DIGLUCONATE
  • Chlorhexidinee Gluconate
  • D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1)
  • compd.withn,n’’-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-d-gluconicaci
  • corsodyl
  • d-)(2:1
  • d-gluconicacid,compd.withn,n’’-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-t
  • disteryl
  • etraazatetradecanediimidamide(2:1)
  • gluconicacid,compd.with1,1’-hexamethylenebis(5-(p-chlorophenyl)biguanide
  • hibiclens
  • hibidil
  • hibiscrub
  • hibitane5
  • orahexal
  • peridex(antiseptic)
  • placout
  • plurexid
  • ChlorhexidineDigluconate,20%Solution
  • ChlorhexidineGluconate20%SolutionChlorhexidineGluconate20%SolutionBp/Usp/Ep
  • ChlorhedineGluconate
  • CHLOROHEXIDINE DIGLUCONATE
  • CHLOROHEXIDINE GLUCONATE
  • CHLOROHEXIDINE DIGLUCONATE, SOLUTION
  • Chlorhexidin bigluconate
  • D-Gluconic acid, compd. with N,N-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1)
  • chlorhexidine digluconate solution
  • CHLORHEIXIDINE GLUCONATE
  • CHLORHEXIDINE GLUCONATE SOLID
  • CHLORHEXIDINE GLUCONATE SOLUTION
  • Chlorhexidindigluconat
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