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Chlorhexidine digluconate

Chemical Name:
Chlorhexidine digluconate
CHLORHEXIDINE GLUCONATE;CHLOROHEXIDINE GLUCONATE;CHLORHEXIDINE GLUCONATE SOLUTION;chlorhexidine digluconate solution;CHLOROHEXIDINE DIGLUCONATE;D-Gluconic acid, compd. with N,N-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide (2:1);septeal;Periogard;hibiclens;CHLORHEIXIDINE GLUCONATE
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
Last updated:2024-06-11 10:30:27

Chlorhexidine digluconate Properties

Density 1.06 g/mL at 25 °C(lit.)
vapor pressure 0.005Pa at 25℃
storage temp. 2-8°C
solubility water: soluble50% (w/v)
form Liquid
color Colorless
Viscosity 2.51mm2/s
Water Solubility 750g/L at 20℃
λmax 257nm(H2O)(lit.)
Sensitive Light Sensitive
Merck 14,2091
SMILES N(C1C=CC(Cl)=CC=1)C(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1C=CC(Cl)=CC=1.[C@@H](O)([C@@H](O)C(=O)O)[C@H](O)[C@H](O)CO |&1:34,36,41,43,r|
LogP -1.81 at 20.7℃
CAS DataBase Reference 18472-51-0(CAS DataBase Reference)
EWG's Food Scores 2-4
NCI Drug Dictionary chlorhexidine gluconate
EPA Substance Registry System Chlorhexidine gluconate (18472-51-0)


Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
Signal word  Danger
Hazard statements  H318-H410
Precautionary statements  P273-P280-P305+P351+P338-P391-P501
Hazard Codes  N
Risk Statements  50/53
Safety Statements  61
WGK Germany  -
RTECS  DU1950000
HazardClass  9
PackingGroup  III
HS Code  29252900
Toxicity LD50 in mice (mg/kg): 22 i.v.; 1800 orally (Foulkes)
NFPA 704
2 0

Chlorhexidine digluconate price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C9394 Chlorhexidine digluconate solution 20% in H2O 18472-51-0 25ml $61.7 2024-03-01 Buy
Sigma-Aldrich C9394 Chlorhexidine digluconate solution 20% in H2O 18472-51-0 100ml $162 2024-03-01 Buy
TCI Chemical C3105 Chlorhexidine Digluconate (20% in Water) 18472-51-0 25mL $27 2024-03-01 Buy
Alfa Aesar 041385 Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile 18472-51-0 25ml $34.5 2024-03-01 Buy
Alfa Aesar 041385 Chlorhexidine digluconate, 20% w/v aq. soln., non-sterile 18472-51-0 *4x500ml $628 2024-03-01 Buy
Product number Packaging Price Buy
C9394 25ml $61.7 Buy
C9394 100ml $162 Buy
C3105 25mL $27 Buy
041385 25ml $34.5 Buy
041385 *4x500ml $628 Buy

Chlorhexidine digluconate Chemical Properties,Uses,Production


Chlorhexidine digluconate solution is a bis(biguanide) family cationic broad spectrum antibiotic that is available in a range of concentrations and has been safely used for over 40 years for a variety of health-related applications; but its specific use for umbilical cord care was uniquely tested in three clinical trials in Nepal, Bangladesh, and Pakistan, in the form of 7.1% chlorhexidine digluconate (CHX). Given the promising results of the trials, in 2013 the World Health Organization (WHO) added CHX to its Model List of Essential Medicines for Children; and in 2014 the WHO issued a new guideline on umbilical cord care, which included a formal recommendation on the use of chlorhexidine.
Chlorhexidine digluconate is a broad spectrum antiseptic. Its mechanism of action involves destabilization of the outer bacterial membrane. It is effective on both Gram-positive and Gram-negative bacteria, although it is less effective with some Gram-negative bacteria.It has both bactericidal and bacteriostatic mechanisms of action, the mechanism of action being membrane disruption, not ATPase inactivation as previously thought.It is also useful against fungi and enveloped viruses, though this has not been extensively investigated. Chlorhexidine is harmful in high concentrations, but is used safely in low concentrations in many products, such as mouthwash and contact lens solutions.

Chemical Properties

Almost colourless or pale-yellowish liquid.


Abacil,Polfa-Lodz SA,Poland


Hydrogenolysis of benzyl-nitrogen bonds. Chlorhexidine gluconate is an antimicrobial irrigant that is used as an antiseptic for the skin in the healthcare industry. It is used in hospitals to prevent infection of patients during surgeries and can also be found in mouthrinses.


Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
Chlorhexidine digluconate 20% solution is a broad spectrum bacteriostatis antiseptic agent, oral care agent, disinfectant, cosmetic biocide, and preservative. It is very effective against plaque, oral flora including Candida and is active against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It can be used in antiseptic soap, mouthwash that fights plaque, disinfecting wounds and burns, vaginal flushing, hair dyes and bleaches, makeup, and other skin and hair care products.


chlorhexidine digluconate is a preservative generally used in concentrations of 0.01 to 0.1 percent to protect against bacteria. It is unstable at high temperatures. Chlorhexidine digluconate is more widely used in europe than in the united States.


ChEBI: Chlorhexidine gluconate is an organochlorine compound and a D-gluconate adduct. It has a role as an antibacterial agent. It is functionally related to a chlorhexidine.

Manufacturing Process

35 parts of hexamethylene bis-dicyandiamide, 35 parts of p-chloroaniline hydrochloride and 250 parts of β-etoxyethanol are stirred together at 130- 140°C for 2 hours under reflux. The mixture is then cooled and filtered. The solid is washed with water and crystallised from 50% aqueous acetic acid. 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) is obtained as colorless plates, melting point 258-260°C. By addition of D-gluconic acid to aqueous solution of chlorhexidine base is prepared 1,1'-hexamethylenebis(5-(pchlorophenyl)biguanide)digluconate (1:2).

brand name

Dyna-Hex (Xttrium); Hibiclens (Regent); Peridex (Zila); Periochip (Dexcel); Periogard (Colgate); Prevacare (Johnson & Johnson).

Therapeutic Function


General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Cationic broad-spectrum antimicrobial agent belonging to the bis(biguanide) family. Its mechanism of action involves destabilization of the outer bacterial membrane. It is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs.

Clinical Use

1,6-Di(4 -chlorophenyldiguanido)hexane gluconate (Hibiclens)is the most effective of a series of antibacterial biguanides originallydeveloped in Great Britain.
The antimicrobial properties of the biguanides were discoveredas a result of earlier testing of these compounds aspossible antimalarial agents. Although thebiguanides are technically not bisquaternary ammoniumcompounds and, therefore, should probably be classifiedseparately, they share many physical, chemical, and antimicrobialproperties with the cationic surfactants. Thebiguanides are strongly basic, and they exist as dications atphysiological pH. In chlorhexidine, the positive charges arecounterbalanced by gluconate anions (not shown). Likecationic surfactants, these undergo inactivation when mixedwith anionic detergents and complex anions such as phosphate,carbonate, and silicate.
Chlorhexidine has broad-spectrum antibacterial activitybut is not active against acid-fast bacteria, spores, orviruses. It has been used for such topical uses as preoperativeskin disinfection, wound irrigation, mouthwashes, andgeneral sanitization. Chlorhexidine is not absorbedthrough skin or mucous membranes and does not causesystemic toxicity.

Chlorhexidine digluconate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 594)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21676 55
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 China 34571 58
Mainchem Co., Ltd.
-- China 6572 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651 China 3002 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 China 2503 58
Wuhan Quanjinci New Material Co.,Ltd.
+8615271838296 China 1534 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 China 20361 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 China 973 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618740459177 China 1142 58
Ouhuang Engineering Materials (Hubei) Co., Ltd
+86-86177 China 2952 58

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View Lastest Price from Chlorhexidine digluconate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chlorhexidine digluconate pictures 2024-07-12 Chlorhexidine digluconate
US $6970.00-6950.00 / metric tonnes 1metric tonnes 99% 100tons Hebei Dangtong Import and export Co LTD
Chlorhexidine gluconate pictures 2024-06-26 Chlorhexidine gluconate
US $20.00 / L 1L 99% 1000KG hebei hongtan Biotechnology Co., Ltd
Chlorhexidine gluconate powder  pictures 2024-06-26 Chlorhexidine gluconate powder
US $30.00-10.00 / kg 10kg 99% 20 tons hebei hongtan Biotechnology Co., Ltd

Chlorhexidine digluconate Spectrum

abacil ChlorhexidineDigluconate,20%Solution ChlorhexidineGluconate20%SolutionChlorhexidineGluconate20%SolutionBp/Usp/Ep ChlorhedineGluconate CHLOROHEXIDINE DIGLUCONATE, SOLUTION Chlorhexidin bigluconate CHLORHEXIDINE GLUCONATE SOLID Chlorhexidindigluconat CHLORHEXIDINE DIGLUCONATE 20% SOLUTION IN WATER Chlorhexidine digluconate, 20% w/v aq. soln. Chlorhexidine digluconate, 20% wv Aqueous Solution, BP Chlorhexidine solution digluconate arlacideg bacticlens caswellno.481g chlorhexidinedi-d-gluconate chlorhexidinedigluconate20%aqueous*solution chlorhexidinglukonatu compd.withn,n’’-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-d-gluconicaci corsodyl d-)(2:1 d-gluconicacid,compd.withn,n’’-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-t disteryl etraazatetradecanediimidamide(2:1) hibidil hibiscrub hibitane5 orahexal peridex(antiseptic) placout plurexid Chlorhexidine gluconate (jp15/usp) D00858 Hibiclens (tn) Peridex (tn) Periogard (tn) Chlorhexidine digluconate w/v aq. soln. Chlorhexidine digluconate, 20% w/v aq. soln. (non-sterile) Chlorhexidini G1uconate solution Chlorhexidine Digluconate (20% in Water) CHLORHEXADINE GLUCONATE 20% CHLORHEXIDINE DIGLUCONATE 20% AQUEOU Chlorhexidine digluconate, Non-sterile D-Digluconate CHLORHEXIDINE DIGLUCONATE 1,6-BIS[N5-(P-CHLOROPHENYL)-N1-BIGUANIDO]HEXANE DIGLUCONATE 1,6-DI(N-P-CHLOROPHENYL-DIGUANIDO) HEXANE DIGLUCONATE 1,1'-HEXAMETHYLENEBIS[5-(P-CHLOROPHENYL)BIGUANIDE]) DIGLUCONATE .alpha.-Cymen-5-ol 1,1’-hexamethylenebis(5-(p-chlorophenyl)-biguaniddigluconate 1,6-bis(5-(p-chlorophenyl)biguandino)hexanedigluconate 3-Methyl-4-(1-methylethyl)phenol tetraazatetradecanediimidamide(2:1) unisept Chlorhexidinee Gluconate D-gluconic acid, compound with N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediamidine (2:1) Glucose Chlorhexidine Acetate 20% Chlorhexidine Glucose Chlorhexidine Digluconate (20% in Water) >