Tetracain

Tetracain Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
R43:Sensibilisierung durch Hautkontakt möglich.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Chemische Eigenschaften

White or light-yellow, waxy solid. Very slightly soluble in water; soluble in alcohol, ether, benzene, chloroform.

Verwenden

Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.

Definition

ChEBI: A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.

Biologische Funktion

Tetracaine hydrochloride (Pontocaine) is an ester of PABA that is an effective topical local anesthetic agent and also is quite commonly used for spinal (subarachnoid) anesthesia. Epinephrine is frequently added to prolong the anesthesia.Tetracaine is considerably more potent and more toxic than procaine and cocaine. It has approximately a 5-minute onset and 2 to 3 hours of action.

Allgemeine Beschreibung

Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.

Tetracain Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Tetracain Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
Lihe Pharm Technology（Wuhan）Co.,Ltd	+8618071517867	info@lihepharma.com	China	194	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1100	58
Wuhan Ruichi Technology Co., Ltd	+8613545065237	admin@whrchem.com	China	164	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	436	58
Anhui Yiao New Material Technology Co., Ltd	+86-199-55145978 +8619955145978	sales8@anhuiyiao.com	China	253	58
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.	+8615571922873	15571922873@163.com	China	106	58

94-24-6(Tetracain)Verwandte Suche:

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• 2-(Dimethylamino)ethyl p-(butylamino)benzoate
• 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove
• 2-dimethylaminoethylesterkyselinyp-butylaminobenzoove
• 2-dimethylaminoethylp-butylaminobenzoate
• 4-(butylamino)-benzoicaci2-(dimethylamino)ethylester
• Anetain
• Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
• Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester
• beta-Dimethylaminoethyl p-butylaminobenzoate
• Contralgin
• Diaethylaminoaethanol ester der p-butylaminobenzoesaeure
• diaethylaminoaethanolesterderp-butylaminobenzoesaeure
• Dicain
• Dikain
• Dimethylaminoethyl p-butyl-aminobenzoate
• dimethylaminoethylp-butyl-aminobenzoate
• Fissucain
• Intercain
• Landocaine
• Laudocaine
• Medihaler-tetracaine
• Meethobalm
• Metraspray
• Mucaesthin
• Niphanoid
• p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester
• p-(butylamino)-benzoicaci2-(dimethylamino)ethylester
• p-(butylamino)benzoicacid,2-(dimethylamino)ethylester
• p-butylaminobenzoyl-2-dimethylaminoethanol
• Pontocain
• Pontocaine
• Rexocaine
• Tetrakain
• Uromucaesthin
• LABOTEST-BB LT00772366
• 4-(BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER
• 2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE
• TETRACAINE
• PARA-(BUTYLAMINO)BENZOICACID,2-(DIMETHLAMINO)ETHYLESTER
• BENZOICACID,PARA-(BUTYLAMINO),2-(DIMETHYLAMINO)ETHYLESTER
• TETRACAINE FREE BASE
• TETRACAINE USP
• Tetracaine (base and/or unspecified salts)
• 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl
• Tetracaine Base & HCL
• tetracine
• Chelido-nium majus L.
• Ding Kayin
• Tetracaine HCl (base)
• 2-(Dimethylamino)ethyl 4-(Butylamino)benzoate 4-(Butylamino)benzoic Acid 2-(Dimethylamino)ethyl Ester
• Tetracaine 0.1
• Tetracaine 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester
• Tetracaine powder
• IN STOCK TETRACAINE CAS NO.94-24-6
• Cyproheptadine hydrochloride Solution, 100ppm
• Tetracaine, 99%, a topical local anesthetic
• Tetracaine(cas number94-24-6)
• 2-dimethylaminoethylesterkyselinyp-butylaminobenzoov