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Tetracaine

CAS No.
94-24-6
Chemical Name:
Tetracaine
Synonyms
TETRACAINE BASE;Tetracaina;Dicaine;amethocaine;TETRACAIN;Tetracainum;Dlcalne;Medicaine;Tetracacine;2-(Dimethylamino)ethyl 4-(butylamino)benzoate
CBNumber:
CB9775567
Molecular Formula:
C15H24N2O2
Molecular Weight:
264.36
MDL Number:
MFCD00053787
MOL File:
94-24-6.mol
Last updated:2024-03-18 11:47:05

Tetracaine Properties

Melting point 41.0 to 45.0 °C
Boiling point 407.59°C (rough estimate)
Density 1.0200 (rough estimate)
refractive index 1.5800 (estimate)
storage temp. 2-8°C
solubility soluble in Methanol
form powder to crystal
pka pKa 8.33±0.03(H2O t = 20.0 I = 0.10 (KCl)) (Uncertain)
color White to Almost white
Water Solubility 156mg/L(temperature not stated)
InChI InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChIKey GKCBAIGFKIBETG-UHFFFAOYSA-N
SMILES C(OCCN(C)C)(=O)C1=CC=C(NCCCC)C=C1
LogP 3.510
FDA 21 CFR 310.545
CAS DataBase Reference 94-24-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 0619F35CGV
ATC code C05AD02,D04AB06,N01BA03,N01BA53,S01HA03
NIST Chemistry Reference Tetracaine(94-24-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H317-H351
Precautionary statements  P280-P301+P330+P331+P310
Hazard Codes  Xn,Xi
Risk Statements  22-40-42/43-43
Safety Statements  22-36/37
RIDADR  UN 2811
WGK Germany  3
RTECS  DG4725000
HazardClass  6.1
PackingGroup  III
HS Code  29224999
NFPA 704
0
2 0

Tetracaine price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0002117 Tetracaine European Pharmacopoeia (EP) Reference Standard 94-24-6 Y0002117 $153 2024-03-01 Buy
Sigma-Aldrich T7383 Tetracaine ≥98% (TLC) 94-24-6 25G $172 2024-03-01 Buy
Sigma-Aldrich T7383 Tetracaine ≥98% (TLC) 94-24-6 100G $537 2024-03-01 Buy
Sigma-Aldrich PHR3140 Tetracaine pharmaceutical secondary standard, certified reference material 94-24-6 100MG $200 2024-03-01 Buy
Sigma-Aldrich 1649991 Tetracaine United States Pharmacopeia (USP) Reference Standard 94-24-6 50mg $381 2024-03-01 Buy
Product number Packaging Price Buy
Y0002117 Y0002117 $153 Buy
T7383 25G $172 Buy
T7383 100G $537 Buy
PHR3140 100MG $200 Buy
1649991 50mg $381 Buy

Tetracaine Chemical Properties,Uses,Production

Uses

Tetracaine is used in assessing the potential for drug-nanoparticle surface interactions to improve drug penetration into the skin.

Description

Tetracaine is a local anesthetic or numbing medicine that is used to numb the throat, eyes, or nose. Normally, the drug is administered before starting a surgery to decrease pain from the procedure. Tetracaine is applied to the eyes 30 minutes before the start of an intravenous and its effects can last up to 15 minutes.

Mechanism of Action

Tetracaine acts by blocking the nerve systems. It does this by blocking the sodium ion channels needed for the conduction and initiation of neural impulses, thereby affecting the local anesthesia. Tetracaine acts by altering the function of calcium release channels that controls the release of calcium frim intracellular cells.

Precautions

No studies have revealed whether the medicine can affect an unborn child; however, it is important to inform the doctor if pregnant while using it.

Informing the doctor is paramount if breastfeeding a baby, as no known research has illustrated whether tetracaine can pass into breast milk or harm a nursing baby.

To make tetracaine safe, it is important to inform the doctor if one has a history of spinal or brain injury, heart diseases, eye problems, a blood vessel disorder, open sores, skin injury in the area where the medicine will be applied.

Tetracaine should never be orally taken since it is typically designed for use on the skin only. If the medicine gets in the mouth, nose, vagina, or rectum, rinse with water.

Application

Tetracaine topical (for the skin) is used to numb various body parts before a surgical procedure or a medical test. Conversely, tetracaine ophthalmic drops are used as local anesthetic for the eyes.

Dosage

Always follow all direction on the prescription label. Do not use the medicine in smaller or larger amounts or for longer than recommended.

Side Effects

Seek emergency medical advice in case of any of the following allergic reactions: difficult breathing, hives, swelling of the throat, tongue, lips, or face. Stop using the drug and call the physician if one has severe burning, swelling, stinging, or other irritation of the treated skin. Other alarming symptoms include eye watering, irritation, and increased sensitivity to light.

Common side effects include burning, stinging, or itching at the point of application of the medicine; numbness in places where tetracaine has been accidentally applied or skin redness or tenderness.

Nonclinical Toxicology
Studies conducted to reveal the genotoxicity of tetracaine have not indicated its mutagenesis, carcinogenicity, or impairment of fertility.

Chemical Properties

White or light-yellow, waxy solid. Very slightly soluble in water; soluble in alcohol, ether, benzene, chloroform.

Uses

analgesic

Uses

Tetracaine, also known as amethocaine, is the most potent and lipidsoluble ester local anaesthetic and has significant potential for toxicity if used systemically. It is commonly used as a 4% gel for topical application to decrease the pain from venous puncture or cannulation.

Uses

Topical ophthalmic anesthetic; used for spinal anesthesia

Uses

Tetracaine has been used as an anesthetic and to lower the glucose synthesis in upper small intestinal infusions. It has also been used to inhibit ryanodine receptors (RyRs) in rats.

Definition

ChEBI: A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.

Biological Functions

Tetracaine hydrochloride (Pontocaine) is an ester of PABA that is an effective topical local anesthetic agent and also is quite commonly used for spinal (subarachnoid) anesthesia. Epinephrine is frequently added to prolong the anesthesia.Tetracaine is considerably more potent and more toxic than procaine and cocaine. It has approximately a 5-minute onset and 2 to 3 hours of action.

General Description

Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with lidocaine (EMLA) (an emulsionof lidocaine and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity. Overdoses of tetracaine mayproduce central nervous system (CNS) toxicity and seizure activitywith fatalities from circulatory depression reported.No selective cardiac toxicity is seen with tetracaine althoughhypotension has been reported. Tetracaine is employed for infiltrationanesthesia, spinal anesthesia, or topical use.

Biochem/physiol Actions

Tetracaine also refers as 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester interfere with calcium movement in muscle and non-muscle cells and can inhibit potassium-induced as well as caffeine-induced shortening of outer hair cells (OHC′s). But, the product can′t inhibit electrically-induced shortening of OHC′s.The product can also stimulate caspase activation and inhibits pro-survival signalling pathways which in turn induce human renal cell apoptosis.

Veterinary Drugs and Treatments

Tetracaine is more irritating than proparacaine but is sometimes used in veterinary medicine. It is indicated to produce local anesthesia of short duration for ophthalmic procedures including measurement of intraocular pressure (tonometry), removal of foreign bodies and sutures, and conjunctival and corneal scraping in diagnosis and gonioscopy. Tetracaine is also indicated to produce local anesthesia prior to surgical procedures in humans such as cataract extraction and pterygium excision, usually as an adjunct to locally injected anesthetics. Ophthalmic solutions used for intraocular procedures should be preservative-free. Preservatives may cause damage to the corneal epithelium if a significant quantity of solution enters the eye through the incision.

109-65-9
10012-47-2
94-24-6
Synthesis of Tetracaine from 1-Bromobutane and DIMETHYLPROCAINE

Tetracaine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 424)Suppliers
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Wuhan Haorong Biotechnology Co.,ltd
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View Lastest Price from Tetracaine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tetracaine base pictures 2024-03-19 Tetracaine base
94-24-6
US $0.00-0.00 / kg 1kg 99% 500 Wuhan Haorong Biotechnology Co.,Ltd
Tetracaine pictures 2024-03-19 Tetracaine
94-24-6
US $10.00-1.00 / kg 1kg 99% 300tons Hebei Dangtong Import and export Co LTD
Tetracaine pictures 2024-03-19 Tetracaine
94-24-6
US $435.00-426.00 / kg 1kg 99.99% 100Tons Hebei Dangtong Import and export Co LTD
  • Tetracaine base pictures
  • Tetracaine base
    94-24-6
  • US $0.00-0.00 / kg
  • 99%
  • Wuhan Haorong Biotechnology Co.,Ltd
  • Tetracaine pictures
  • Tetracaine
    94-24-6
  • US $10.00-1.00 / kg
  • 99%
  • Hebei Dangtong Import and export Co LTD
  • Tetracaine pictures
  • Tetracaine
    94-24-6
  • US $435.00-426.00 / kg
  • 99.99%
  • Hebei Dangtong Import and export Co LTD
2-(Dimethylamino)ethyl p-(butylamino)benzoate 2-Dimethylaminoethylester kyseliny p-butylaminobenzoove 2-dimethylaminoethylesterkyselinyp-butylaminobenzoove 2-dimethylaminoethylp-butylaminobenzoate 4-(butylamino)-benzoicaci2-(dimethylamino)ethylester Anetain Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester beta-Dimethylaminoethyl p-butylaminobenzoate Contralgin Diaethylaminoaethanol ester der p-butylaminobenzoesaeure diaethylaminoaethanolesterderp-butylaminobenzoesaeure Dicain Dikain Dimethylaminoethyl p-butyl-aminobenzoate dimethylaminoethylp-butyl-aminobenzoate Fissucain Intercain Landocaine Laudocaine Medihaler-tetracaine Meethobalm Metraspray Mucaesthin Niphanoid p-(Butylamino)benzoic acid, 2-(dimethylamino)ethyl ester p-(butylamino)-benzoicaci2-(dimethylamino)ethylester p-(butylamino)benzoicacid,2-(dimethylamino)ethylester p-butylaminobenzoyl-2-dimethylaminoethanol Pontocain Pontocaine Rexocaine Tetrakain Uromucaesthin LABOTEST-BB LT00772366 4-(BUTYLAMINO)BENZOIC ACID 2-(DIMETHYLAMINO)ETHYL ESTER 2-(DIMETHYLAMINO)ETHYL 4-(N-BUTYLAMINO)BENZOATE TETRACAINE PARA-(BUTYLAMINO)BENZOICACID,2-(DIMETHLAMINO)ETHYLESTER BENZOICACID,PARA-(BUTYLAMINO),2-(DIMETHYLAMINO)ETHYLESTER TETRACAINE FREE BASE TETRACAINE USP Tetracaine (base and/or unspecified salts) 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl Tetracaine Base & HCL tetracine Chelido-nium majus L. Ding Kayin Tetracaine HCl (base) 2-(Dimethylamino)ethyl 4-(Butylamino)benzoate 4-(Butylamino)benzoic Acid 2-(Dimethylamino)ethyl Ester Tetracaine 0.1 Tetracaine 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester Tetracaine powder IN STOCK TETRACAINE CAS NO.94-24-6 Cyproheptadine hydrochloride Solution, 100ppm Tetracaine, 99%, a topical local anesthetic Tetracaine(cas number94-24-6) 2-dimethylaminoethylesterkyselinyp-butylaminobenzoov