Darifenacin hydrobromide
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- CAS-Nr.
- 133099-07-7
- Englisch Name:
- Darifenacin hydrobromide
- Synonyma:
- Emsele;Enablex;Emselex;UK 88525-04;Darifenacin HCl;DARIFENACIN HBR;Darifenacin hydrobro;DARFENACIN HYDROBROMIDE;Darifenacin Hydrobromid;darifenacin hydrobromide
- CBNumber:
- CB9855171
- Summenformel:
- C28H31BrN2O2
- Molgewicht:
- 507.47
- MOL-Datei:
- 133099-07-7.mol
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Darifenacin hydrobromide Eigenschaften
- Schmelzpunkt:
- 228-2300C
- alpha
- 25D -30.3° (c = 1.0 in methylene chloride)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble20mg/mL, clear
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivität
- [α]/D +41 to +49°, c = 1 in methylene chloride
- CAS Datenbank
- 133099-07-7(CAS DataBase Reference)
Darifenacin hydrobromide Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Darifenacin, an orally active, once a day selective M3
receptor antagonist, was launched for the treatment of overactive
bladder in patients with symptoms of urge urinary
incontinence, urgency and frequency. The drug selectively
inhibits M3 receptor in the detrusor muscle while sparing the M1 and M2 receptors that are believed to be involved
in central nervous system and cardiovascular function respectively.
The compound was originally developed by
Pfizer and licensed to Novartis and Bayer.
Chemische Eigenschaften
White Solid
Verwenden
Darifenacin hydrobromide is used as a medication to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.
Definition
ChEBI: The hydrobromide salt of darifenacin. A selective antagonist for the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions, it is used in the management of urinary incontinence.
Allgemeine Beschreibung
Darfenacin (Enablex),(s)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphen-ylacetamide, is an antimuscarinicagent that has selectivity for the M3 muscarinicsubtype receptor. By competitively blocking of the muscarinicreceptors results in a reduction of the smoothmuscle tone, allowing for greater volume of urine to bestored in the bladder. This results in less urinary incontinence,urgency, and frequency. It is a white to almostwhite, crystalline powder, with a molecular weight of507.5. Darifenacin is metabolized by the isozymesCYP2D6 and CYP3A4 with the primary metabolic routesbeing monohydroxylation of the dihydrobenzofuran ring,opening of the dihydrobenzofuran ring, and N-dealkylationof the pyrrolidine nitrogen.
Darifenacin hydrobromide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Darifenacin hydrobromide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 264)Lieferanten
133099-07-7()Verwandte Suche:
- 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenyl-ethanamide hydrobromide
- 2-[(3S)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenyl-acetamide hydrobromide
- Darifenacine Hydrobromide
- Darifenacin hydrobro
- (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α-α-diphenyl-3-pyrrolidineacetaMide HydrobroMide
- Darifenacin hydrobroMide R
- DARFENACIN HYDROBROMIDE
- (S)-3-(Carbamoyldiphenylmethyl)-1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]pyrrolidine hydrobromide
- UK 88525-04
- Darifenacin hydrobromide, >=99%
- Darifenacin HCl
- {1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidnyl}-2,2-diphenylacetamide hydrobromide
- darifenacin hydrobromide
- DARIFENACIN HYDROBROMIDE 99.0%
- Darifenacin hydrobromide (Under R&D)
- (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a-a-diphenyl-3-pyrrolidineacetamide Hydrobromide
- Emsele
- Enablex
- DARIFENACIN HBR
- Darifenacin Hydrobromid
- (3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-α-a-diphenyl-3-pyrrolidineacetamide Hydrobromide
- Emselex
- 2-[(3S)-1-[2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2,2-diphenylacetamide hydrobromide
- Darifenacin Hydrobromide ((3S)-1-[2-(2,3-Dihydro-5-benzofuranyl)ethyl]-a-a-diphenyl-3-pyrrolidineacetamide Hydrobromide
- (S)-2-[1-[2-(2,3-Dihydrobenzfuran-5-yl)ethyl]-3-pyrrolidinyl]-2,2-diphenylacetamide HBr
- 3-Pyrrolidineacetamide, 1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-, hydrobromide (1:1), (3S)-
- Darifenacin hydrobromide USP/EP/BP
- Darifenacin Hydrobromide (10mM in DMSO)
- Darifenacin HBr (UK88525)
- Darifenacin D4 hydrochlorideQ: What is
Darifenacin D4 hydrochloride Q: What is the CAS Number of
Darifenacin D4 hydrochloride Q: What is the storage condition of
Darifenacin D4 hydrochloride Q: What are the applications of
Darifenacin D4 hydrochloride
- Darifenacin HydrobromideQ: What is
Darifenacin Hydrobromide Q: What is the CAS Number of
Darifenacin Hydrobromide Q: What is the storage condition of
Darifenacin Hydrobromide Q: What are the applications of
Darifenacin Hydrobromide
- 133099-07-7 Darifenacin hydrobromide
- Darifenacin Hydrobromide (1164200)
- (S)-2-(1-(2-(2,3-Dihydrobenzofuran-5-yl)ethyl)pyrrolidin-3-yl)-2,2-diphenylacetamide hydrobromide
- 133099-07-7
- 133099-07-1
- 133039-07-7
- C28H30N2O2HBr
- C28H31BrN2O2
- C28H30N2O2
- C28H29BrN2O2
- C28H30N2O2BrH
- Amines
- Aromatics
- Heterocycles
- API
- Intermediates & Fine Chemicals
- Pharmaceuticals
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