LUFFARIELLOLIDE
- CAS No.
- 111149-87-2
- Chemical Name:
- LUFFARIELLOLIDE
- Synonyms
- LUFFARIELLOLIDE;Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha;3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one;4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone;2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
- CBNumber:
- CB0200705
- Molecular Formula:
- C25H38O3
- Molecular Weight:
- 386.57
- MDL Number:
- MFCD00211056
- MOL File:
- 111149-87-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 541.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.006±0.06 g/cm3(Predicted) |
| solubility | DMSO: soluble; Ethanol: soluble |
| pka | 9.98±0.40(Predicted) |
| form | Pale yellow oil. |
| InChI | InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+ |
| InChIKey | JPWPYTMXSXYUPG-QZPYEDBESA-N |
| SMILES | O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O |
LUFFARIELLOLIDE price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14902 | Luffariellolide ≥98% | 111149-87-2 | 1mg | $186 | 2024-03-01 | Buy |
| ChemScene | CS-0068326 | Luffariellolide | 111149-87-2 | 1mg | $473 | 2026-06-04 | Buy |
| ApexBio Technology | C5100 | Luffariellolide | 111149-87-2 | 1mg | $255 | 2026-05-06 | Buy |
| aablocks | AA01E600 | Luffariellolide >98% | 111149-87-2 | 1mg | $349 | 2026-05-30 | Buy |
| TRC | L473753 | Luffariellolide | 111149-87-2 | 0.5mg | $360 | 2021-12-16 | Buy |
LUFFARIELLOLIDE Chemical Properties, Uses, Production
Uses
Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).[Cayman Chemical]
Uses
Luffariellolide is an anti-inflammatory PLA2inhibitor.
Definition
ChEBI: Luffariellolide is a diterpene lactone.
LUFFARIELLOLIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 400-0056266 | marketing1@energy-chemical.com | China | 44139 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Wuhan Topule | +86-02787215551 19945035818 | 2936752263@qq.com | China | 7965 | 58 |
| QUALITY CONTROL SOLUTIONS LTD. | +86-0755-66853366 +86-13670046396 | export03@qcsrm.com | China | 24318 | 58 |
| amyjet | 4006800868;027-59626688 18771149750 | sales@amyjet.com | China | 2909 | 58 |
| Wuhan Augda Biotechnology Co., Ltd | 15071299552 | 262933239@qq.com | China | 7199 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Latest Price from LUFFARIELLOLIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Luffariellolide
111149-87-2
|
$673.00 | 98.00% | 10g | TargetMol Chemicals Inc. |
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- Luffariellolide
111149-87-2
- $673.00
- 98.00%
- TargetMol Chemicals Inc.
