AZD-1208
- CAS No.
- 1204144-28-4
- Chemical Name:
- AZD-1208
- Synonyms
- CS-794;AZD1208;AZD 1208;AZD-1208;AZD1208 >=95%;AZD 1208;AZD-1208;AZD-1208 USP/EP/BP;AZD1208;AZD 1208;AZD-1208;(R,Z)-5-((2-(3-aminopiperidin-1-yl)biphenyl-3-yl)methylene)thiazolidine-2,4-dione;(R,Z)-5-((2-(3-aMinopiperidin-1-yl)-[1,1'-biphenyl]-3-yl)Methylene)thiazolidine-2,4-dione
- CBNumber:
- CB02666594
- Molecular Formula:
- C21H21N3O2S
- Molecular Weight:
- 379.48
- MDL Number:
- MFCD25976757
- MOL File:
- 1204144-28-4.mol
- MSDS File:
- SDS
Melting point | >220°C (dec.) |
---|---|
Density | 1.307±0.06 g/cm3(Predicted) |
storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly) |
pka | 7.39±0.20(Predicted) |
form | Solid |
color | Off-White to Pale Yellow |
FDA UNII | S98NFM1378 |
AZD-1208 price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 20235 | AZD 1208 ≥98% | 1204144-28-4 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 20235 | AZD 1208 ≥98% | 1204144-28-4 | 5mg | $78 | 2024-03-01 | Buy |
Cayman Chemical | 20235 | AZD 1208 ≥98% | 1204144-28-4 | 10mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 20235 | AZD 1208 ≥98% | 1204144-28-4 | 25mg | $230 | 2024-03-01 | Buy |
Tocris | 6310 | AZD1208 ≥98%(HPLC) | 1204144-28-4 | 50 | $386 | 2021-12-16 | Buy |
AZD-1208 Chemical Properties,Uses,Production
Uses
AZD1208 is a potent, and orally available Pim kinase inhibitor.
Biological Activity
upregulation of pim kinases has been observed in several types of leukemias and lymphomas. pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways. azd1208 is a potent, highly selective, and orally available pim kinase inhibitor.
in vitro
azd1208 inhibited the growth of 5 of 14 acute myeloid leukemia (aml) cell lines tested. in molm-16 cells, azd1208 also causes cell cycle arrest and apoptosis, accompanied by a dose-dependent reduction in phosphorylation of bcl-2 antagonist of cell death [1].
in vivo
azd1208 inhibits the growth of kg-1a and molm-16 xenograft tumors in vivo with a clear pk/pd relationship. treatment with 10 mg/kg or 30 mg/kg of azd1208 led to an 89% tumor growth inhibition or slight regression, respectively [1].
target
Pim1
IC 50
0.4 nm for pim-1, 5.0 nm for pim-2, and 1.9 nm for pim-3
storage
Store at -20°C
References
[1] keeton ek, mceachern k, dillman ks, palakurthi s, cao y, grondine mr, kaur s, wang s, chen y, wu a, shen m, gibbons fd, lamb ml, zheng x, stone rm, deangelo dj, platanias lc, dakin la, chen h, lyne pd, huszar d. azd1208, a potent and selective pan-pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. blood. 2014;123(6):905-13.
AZD-1208 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23899 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9817 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from AZD-1208 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-09-02 | AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione
1204144-28-4
|
US $1.00-1.00 / KG | 1KG | 98% | 1lg; 2kg; 5kg; 10kg; 100kg | Career Henan Chemical Co |
- AZD 1208;AZD1208;AZD-1208;(5Z)-5-[[2-[(3R)-3-aMino-1-piperidinyl][1,1'-biphenyl]-3-yl]Methylene]-2,4-thiazolidinedione
1204144-28-4
- US $1.00-1.00 / KG
- 98%
- Career Henan Chemical Co