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D-Pyroglutamic acid

Chemical Name:
D-Pyroglutamic acid
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:

D-Pyroglutamic acid Properties

Melting point 155-162 °C
alpha 27.5 º (c=10,1N NaOH)
Boiling point 239.15°C (rough estimate)
Density 1.3816 (rough estimate)
refractive index 10 ° (C=5, H2O)
storage temp. Sealed in dry,Room Temperature
solubility Dimethylformamide, DMSO (Slightly), Methanol (Slightly), Water
form Solid
pka 3.48±0.20(Predicted)
color Off-White to Light Beige
optical activity [α]22/D +10°, c = 1.5 in H2O
Water Solubility soluble
Merck 14,8001
BRN 82133
CAS DataBase Reference 4042-36-8(CAS DataBase Reference)


Risk and Safety Statements

Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
HS Code  29339900

D-Pyroglutamic acid price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 422614 (R)-(+)-2-Pyrrolidone-5-carboxylic acid 95% 4042-36-8 10g $133 2022-05-15 Buy
TCI Chemical P1354 D-Pyroglutamic Acid >98.0%(T) 4042-36-8 5g $63 2022-04-27 Buy
TCI Chemical P1354 D-Pyroglutamic Acid >98.0%(T) 4042-36-8 25g $156 2022-04-27 Buy
Alfa Aesar B24678 (R)-(+)-2-Pyrrolidinone-5-carboxylic acid, 98+% 4042-36-8 5g $63.5 2022-04-27 Buy
Alfa Aesar B24678 (R)-(+)-2-Pyrrolidinone-5-carboxylic acid, 98+% 4042-36-8 25g $206 2022-04-27 Buy
Product number Packaging Price Buy
422614 10g $133 Buy
P1354 5g $63 Buy
P1354 25g $156 Buy
B24678 5g $63.5 Buy
B24678 25g $206 Buy

D-Pyroglutamic acid Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde


Serves as a building block in the synthesis of diphthamide.


Serves as a building block in the synthesis of diphthamide


ChEBI: The D-enantiomer of 5-oxoproline.

Purification Methods

Purify R-pyroglutamic acid by dissolving it in H2O, filtering, passing the filtrate through Dowex 50 (H+ form), washing with H2O, pooling washings, evaporating, removing H2O azeotropically with Me2CO and *C6H6, washing the residue with Et2O and recrystallising from EtOH/pet ether. [Pradeller et al. Collect Czech Chem Commun 42 79, 80 1977, Beilstein 22/6 V 7.]

Synthesis of D-Pyroglutamic acid from D(-)-Glutamic acid
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View Lastest Price from D-Pyroglutamic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-09 D-Pyroglutamic Acid
US $100.00 / KG 25KG 99.99% 200ton Hebei Mojin Biotechnology Co., Ltd
2021-09-29 D-Pyroglutamic acid
US $0.00-0.00 / Kg/Drum 1KG 98%-101% 1000KG WUHAN FORTUNA CHEMICAL CO., LTD
2021-08-07 D-Pyroglutamic acid
US $1.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
(R)-5-PYRROLIDONE-2-CARBOXYLIC ACID (R)-(+)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID (R)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID (R)-(+)-2-PYRROLIDINONE-5-CARBOXYLIC ACID (R)-2-PYRROLIDINONE-5-CARBOXYLIC ACID (R)-(+)-2-PYRROLIDONE-5-CARBOXYLIC ACID (R)-2-PYRROLIDONE-5-CARBOXYLIC ACID 5-OXO-D-PROLIN 2-PYRROLIDINONE-(R)-5-CARBOXYLIC ACID D-GLUTAMIC ACID LACTAM D-5-OXO-2-PYRROLIDINECARBOXYLIC ACID d-5-pyrrolidone-2-carboxylic acid (+)-D-PYROGLUTAMIC ACID D-PYROGLUTAMIC ACID D-PROLINE, 5-OXO- H-D-PGLU-OH (2R)-5-Oxopyrrolidin-2-ylcarboxylic acid R-2-PYRROLIDONE-5-CARBOXYLIC ACID 97% D-Pyroglutamicacid=H-D-Pyr-OH=D-2-Pyrrolidone-5-carboxylicacid D-2-PYRROLIDONE-5-CARBOXYLIC ACID D-5-Oxoproline (R)-(+)-2-Pyrrolidone-5-carboxylic acid, 98+% D-Pyroglutamic (2R)-5-oxopyrrolidine-2-carboxylic acid D- pGlu-OH (R)-(+)-2-PYRROLIDINONE-5-CARBOXYLIC ACID, 98+% D-Pyrroglutamic acid D-Pyroglutamic acid, (R)-2-Pyrrolidone-5-carboxylic acid, (R)-5-Oxo-2-pyrrolidinecarboxylic acid D-5-Oxo-2-pyrrolidinecarboxylic acid, D-Pyroglutamic acid (R)-2-Pyrrolidone-5-carboxylic acid, (R)-5-Oxo-2-pyrrolidinecarboxylic acid D-Pyroglutamic acid ,98% (R)-5-Oxoproline (R)-PyroglutaMic Acid D-Pyrrolidinonecarboxylic Acid D-Pyrrolidonecarboxylic Acid D-Glutamic Acid Lactam (R)-5-Oxopyrrolidine-2-carboxylic Acid (R)-5-Pyrrolidone-2-carboxylic Acid 223-735-0 D-Pyr-OH≥ 99% (assay) (2R)-5-oxo-2-pyrrolidinecarboxylate D-Pyroglutamic Aicd D-PyroglutamicAcid> D-Pyrog D-PyrogL D-Pyroglutamic acid USP/EP/BP (R)-5-OXOPYRROLIDINE-2-CARBOXYLIC ACID 5-OXO-D-PROLINE D-PYR-OH H-D-PYR-OH D-pyroglutamate 4042-36-8 C5H7NO3 Optical Resolution for Resolution of Bases Peptide Synthesis Others Pyroglutamine Derivatives Unnatural Amino Acid Derivatives Specialty Synthesis