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Niraparib

Niraparib
Niraparib structure
CAS No.
1038915-60-4
Chemical Name:
Niraparib
Synonyms
CS-2299;Niraparib;EOS-60867;MK4827 (Niraparib);Niraparib (MK-4827);MK 4827;MK-4827;MK4827;Niraparib(MK4827) free base;2-[4-(3S)piperidin-3-ylphenyl]-2H-indazol-7-carboxamide;2-[4-[(3s)-piperidin-3-yl]phenyl]indazole-7-carboxamide;2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-
CBNumber:
CB82514860
Molecular Formula:
C19H20N4O
Formula Weight:
320.3883
MOL File:
1038915-60-4.mol

Niraparib Properties

Boiling point:
463.6±45.0 °C(Predicted)
Density 
1.34
pka
15.36±0.30(Predicted)
FDA UNII
HMC2H89N35

Niraparib Chemical Properties,Uses,Production

Description

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide is also known as MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 (The poly(ADP-ribose) polymerase) with great activity in cancer cells with mutant BRCA-1 and BRCA-2. It has been recently approved by FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy. In vitro studies have shown that niraparib-induced cytotoxicity may involve inhibition of PARP enzymatic activity and increased formation of PARP-DNA complexes resulting in DNA damage, apoptosis and cell death.

Pharmacology

The synthesis and initial pharmacology of niraparib have been published. Niraparib has affinity for PARP 1 and 2 inhibition (IC50 = 3.8 and 2.1 nM, respectively) and inhibits the proliferation of cancer cells with mutant BRCA1 and BRCA2 with IC50 values in the 10–100 nM range in vitro. Niraparib demonstrated efficacy as a single agent in a xenograft model of BRCA1-deficient cancer. Niraparib has also been reported to act as a preclinical radiosensitiser and has entered into clinical oncology trials.

References

https://newdrugapprovals.org/2016/12/22/niraparib-mk-4827/
https://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm548487.htm
https://www.drugbank.ca/drugs/DB11793
Sandhu, Shahneen K, et al. "The poly (ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA, mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial." Lancet Oncology14.9 (2013):882.
Jones, P, et al. "Niraparib: A Poly (ADP-ribose) Polymerase (PARP) Inhibitor for the Treatment of Tumors with Defective Homologous Recombination. " Journal of Medicinal Chemistry 58.8(2015):3302-14.

Niraparib Preparation Products And Raw materials

Raw materials

Preparation Products


Niraparib Suppliers

Global( 157)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24723 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
QQ:800182836 stella@zetchem.com CHINA 2886 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5921 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58

View Lastest Price from Niraparib manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-31 Niraparib
1038915-60-4
US $100.00 / KG 1KG 98% 100KG career henan chemical co

1038915-60-4(Niraparib)Related Search:


  • MK 4827;MK-4827;MK4827
  • Niraparib(MK4827) free base
  • 2-[4-(3S)piperidin-3-ylphenyl]-2H-indazol-7-carboxamide
  • EOS-60867
  • 2-[4-[(3s)-piperidin-3-yl]phenyl]indazole-7-carboxamide
  • (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide
  • MK-4827,(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
  • Niraparib
  • 2-[4-((3S)-3-Piperidinyl)phenyl]-2H-indazole-7-carboxamide
  • MK4827 (Niraparib)
  • 2H-Indazole-7-carboxamide, 2-[4-(3S)-3-piperidinylphenyl]-
  • (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide hydrocholoride
  • Niraparib (MK-4827)
  • CS-2299
  • 1038915-60-4
  • API
  • Anti-cancer&immunity
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