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Chemical properties uses Identification test Content analysis Toxicity Usage limit Production method Hazards & Safety Information
2-Phenylphenol structure
Chemical Name:
OPP;Xenol;FR-OPP;Nectryl;o-Xenol;o-Xonal;Torsite;90-43-7;remoltrf;FEMA 3959
Molecular Formula:
Formula Weight:
MOL File:

2-Phenylphenol Properties

Melting point:
57-59 °C(lit.)
Boiling point:
282 °C(lit.)
vapor pressure 
7 mm Hg ( 140 °C)
refractive index 
1.6188 (estimate)
Flash point:
255 °F
storage temp. 
Store below +30°C.
Soluble in ethanol, acetone, benzene,sodium hydroxide, chloroform, acetonitrile, toluene, hexane, ligroin, ethyl ether, pyridine, ethylene glycol, isopropanol, glycol ethers and polyglycols.
Crystalline Flakes
10.01(at 25℃)
7 (0.1g/l, H2O, 20℃)
explosive limit
Water Solubility 
0.7 g/L (20 ºC)
JECFA Number
Stable. Combustible. Incompatible with strong oxidizing agents, halogens.
CAS DataBase Reference
90-43-7(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
EWG's Food Scores
Proposition 65 List
NIST Chemistry Reference
3 (Vol. 73) 1999
EPA Substance Registry System
2-Phenylphenol (90-43-7)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302-H315-H319-H335-H400
Precautionary statements  P280a-P304+P340-P501a-P264-P270-P271-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P391-P403+P233-P405-P501-P261-P273-P305+P351+P338
Hazard Codes  Xi,N
Risk Statements  36/37/38-50-37/38/50-36
Safety Statements  22-61
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  DV5775000
Autoignition Temperature >520 °C
HazardClass  9
PackingGroup  III
HS Code  29071900
Toxicity LD50 orally in rats: 2.48 g/kg (Hodge)
NFPA 704
3 0

2-Phenylphenol price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 45529 2-Phenylphenol PESTANAL , analytical standard 90-43-7 250mg $39.4 2021-03-22 Buy
Sigma-Aldrich P28263 2-Phenylphenol 99% 90-43-7 2kg $199 2021-03-22 Buy
TCI Chemical P0200 2-Phenylphenol >99.0%(GC) 90-43-7 25g $26 2021-03-22 Buy
TCI Chemical P0200 2-Phenylphenol >99.0%(GC) 90-43-7 500g $95 2021-03-22 Buy
Alfa Aesar A10592 2-Phenylphenol, 99% 90-43-7 250g $35 2021-03-22 Buy

2-Phenylphenol Chemical Properties,Uses,Production

Chemical properties

Bright purple crystals


1. Fungicides: fruit and vegetable preservative. It is mainly used for the treatment of citrus epidermis mold.
2. For the European Economic Community countries and the United States, in addition to be applied citrus, can still use it for cucumber, carrot, apple, melon, tomatoes and so on. Japan is limited to citrus with the maximum residue 0.01g/kg (1990).
3. The usage condition of each country is as follows (allowable amount, mg/kg) Canadian cherry, 5; citrus, cucumber, pepper, pineapple, tomato, 10; sweet potato, 15; carrot, peach, plum fruit, 20; ; Melon, 12. European citrus, 12. Dutch citrus, 10. English citrus, 70; apple, pear, pineapple, 10; melon, 125. Orange, pepper, pineapple, tomato, sweet potatoes, 15; carrots, peaches, plums, pears, pears, pears, pears, pears, pomegranates, citrus, cucumber, grapefruit: 20; apple, pear, 25; Roman melon, 125 (edible part ≤10).
4. Usage method: The goods is embedded into wax at about 0.8% with spray or dipping way for treatment, being able to prevent the corruption caused by the Gectricnumdidum. This product is of the best efficacy with biphenyl. For the treatment of mildew caused by P. digitation in citrus, 60.% of the untreated product was moldy in about 3 to 5 weeks while only 3.4% of the treated product became moldy finally.
5. 2-Phenylphenol can be used as antiseptic fungicide. China provides that it can be used for citrus preservation with the maximum usage amount of 3.0g/kg and the residue amount being not greater than 12 mg/kg.
6. As antiseptic fungicide, the provisions of China can also be used for citrus preservation, the maximum use of 3.0g/kg and residue being not greater than 12mg/kg.
7. 2-Phenylphenol is used for strong bactericidal function, being used for the preservation of wood, leather and paper as well as storage of fruits and vegetables and meat preservation.
8.  2-hydroxy biphenyl is used as the carrier of carrier dyeing method of hydrophobic synthetic fiber polyvinyl chloride and polyester, surfactants, bactericidal preservatives, dye intermediates. In Japan, 2-hydroxy biphenyl and sodium salt is used for the prevention of citrus mildew. We can embed into wax with 0.8% of the product and spray into the post-harvest citrus, or can also use it in combination with biphenyl, being able to minimize the corruption. Britain, the United States, and Canada allow the use of a larger range of fruits, including apples, pears, pineapple and so on. The goods, as a preservative is also used in cosmetics. The oral LD50 of 2-hydroxybiphenyl to rats was 2.7-3.0 g/kg.
9. It can be used for preservation of fruits and vegetables.
10. 2-Phenylphenol can be applied to fluorescence determination of triose. It can also be used as Dye intermediates.
11. Used as a deoxyribonuclease (DNase) inhibitor;

Identification test

Take 1 mL of 1% ethanol solution, plus 4 mL of 0.2% borax solution and a small amount of small crystals of 2,6-dichloro benzoquinone chloride imine, after shaking, the solution should be green to blue.
Take 1 mL of 1% of the sample ethanol solution, plus 1 mL of formaldehyde sulfuric acid solution (TS-113), the interface should be red.

Content analysis

Accurately weigh about 2 g of powder sample, add 25 mL of sodium hydroxide test solution (TS-224), if necessary, it can be warmly dissolved. Add water to 500ml after cooling and take it as a sample solution. Take 25 mL of this sample solution and transfer into the iodine bottle, accurately add 30 mL of 0.1mol/L potassium bromate solution plus 5 mL potassium bromide test solution (TS-181) 5 mL and 50 mL methanol for thoroughly shaking. Quickly add about 10 mL of 1: 1 dilute hydrochloric acid, immediately plug and gently shake for a reaction of 30s. Take 15 ml of potassium iodide solution (TS-192) and place into the upper part of the iodine bottle, and the stopper was let out to let it flow in. After thoroughly rinsing the stopper and bottle with water, the sample was shaken for 5 min. The free iodine was titrated with 0.1 mol/L sodium thiosulfate solution and the starch test solution (TS-235) was used as the indicator. The same method is applied for blank test to obtain content according to the following formula.
Content (%) = 4.255 × (a-b) /sample amount (g) × 50 × 100%
Where a-blank consumption of sodium thiosulfate volume, m1;
B-Sample solution consumption of sodium thiosulfate volume, ml.


ADI: 0 to 0.2 mg/kg (0.2 to 1.0 mg/kg under certain conditions; FAO/WHO, 2001).
LD50: 2.7 to 3.0 g/kg (rat, oral).
The Tokyo health institute in Japan has found that experimental animals have a significant role in bladder cancer.

Usage limit

GB 2760-2001: citrus fresh 1.0g/kg, residues ≤ 12mg/kg.

Production method

(1) It can be recovered from the distillation residue of the process of phenol production via sulfonation. The phenol distillation residue contains about 40% of phenyl phenol with the other components including phenol, inorganic salts, water and so on. After vacuum distillation, the mixed phenyl phenol fraction is separated out with the vacuum being 53.3-66.7kPa. The temperature, started to be cut at 65-75 ℃ to until 100 ℃ above, but should not higher than 1345 ℃. Then take advantage of the solubility difference of ortho, p-hydroxy biphenyl in the trichlorethylene, the two are separated into pure product. The mixed material (mainly 2-hydroxy biphenyl and 4-hydroxy biphenyl) is heated to be dissolved in the trichlorethylene, after cooling, first precipitate out 4-hydroxy biphenyl crystal. After centrifuge filtration, dry to obtain 4-hydroxy biphenyl. The mother liquor was washed with a sodium carbonate solution, followed by dilute alkaline to make the 2-hydroxybiphenyl salt. After standing stratification, take the upper 2-hydroxybiphenyl sodium salt for dehydration under reduced pressure, namely, sodium salt products. The 2-hydroxybiphenylsodium salt is white to light red powder, being easily soluble in water with the solubility in 100g of water being 122g. The pH value of the 2% aqueous solution is 11.1-12.2. It is also easily soluble in acetone, methanol, soluble in glycerol, but insoluble in oil. The sodium salt of 2-hydroxy biphenyl, after acidification, can lead to the formation of 2-hydroxy biphenyl with both of them being food additives.
(2) The mixture of 2-Phenylphenol (o-phenylphenol) and p-phenylphenol is obtained from the by-product of the phenol production by the sulfonation process. The mixture is heated and dissolved in trichlorethylene. After cooling crystallization, we can obtain para-phenylphenol with centrifuge filtering and solid drying to obtain Phenylphenol. The mother liquor was washed with sodium carbonate solution, neutralized with dilute sodium hydroxide and acidified to give o-phenylphenol.
(3) The distillation residue of sulfonation method for production of phenol production contains about 40% of the mixed (para and ortho) phenyl phenol. Taking advantage of difference of the fractionation and solubility in the trichlorethylene, separate and recover ortho products.
The above distillation residue is subject to vacuum distillation at 53.3~66.7 kPa, collecting the distillate fraction at 65~100 °C, namely mixed phenyl phenol. The mixture was heated to be dissolved in trichlorethylene with cooling first precipitating out the para-phenyl phenol. After centrifugal filtration, wash the mother liquor with sodium carbonate solution so that the o-phenyl phenol will become sodium salt. After standing, take the upper sodium salt, after acidification, we can obtain the product.
(4) It can be obtained through the co-heating of dibenzofuran and sodium metal to about 200 °C with the resulting product subjecting to acid decomposition.
(5) It can be obtained through the diazotization and further hydrolysis of 2-aminobiphenyl.

Hazards & Safety Information

Category Pesticides
Toxic classification poisoning
Acute toxicity Oral-rat LD50: 2000 mg/kg; oral-mouse LD50: 1050 mg/kg
Stimulation Data Skin-Rabbit 20 mg/24hours Moderate; Eyes-Rabbit 0.05 mg/24 h Severe
EXPLOSIVES HAZARDOUS CHARACTERISTICS being explosive when being mixed with air
Flammability and Hazardous properties being flammable with combustion producing irritating fumes
Storage and transportation characteristics Ventilated, low temperature and drying
Fire extinguishing agent dry powder, foam, sand


OPP is more selective than other free phenols but does produce phytotoxic effects. Sodium o-phenylphenate (SOPP) is used in practice because it is much less phytotoxic to fruits and has a greater water solubility. Tomkins (42) tried to diminish the phytotoxic effect by esterification of the phenolic group. Acetate and butyrate esters gave efficient control of Botrytis on grapes and Monilia on peaches, but esters of o-phenylphenol are easily hydrolyzed into the free phenol (43). The methyl ether was less active against Diplodia and virtually inactive against Penicillia.

Chemical Properties

Off-white powder

Chemical Properties

o-Phenylphenol is a white to buff-colored crystalline solid.

Chemical Properties

2-Phenylphenol has a distinct odor. It emits acrid smoke and irritating fumes when it is heated to decomposition.


2-Phenylphenol is used for the post-harvest control of storage diseases of apples, citrus fruit, stone fruit, tomatoes, cucumbers and other vegetables. It is also used for the protection of textiles and timber and as a fungistat in water-soluble paints. It is used as the sodium salt in paint and some other applications.


2-Phenylphenol is a agriculture fungicide and is no longer used as a food additive.


2-phenylphenol is remarkably versatile organic chemical products, widely used antiseptic, auxiliaries and surfactant synthesis of new plastics, resins and polymer materials in areas such as stabilizers and flame retardants.


ChEBI: A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.


From chlorobenzene.

Production Methods

OPP is produced as a by-product in the manufacture of diphenyl oxide or by aldol condensation of hexazinone. Current global production is estimated to be less than 10 million lb per year. Chief uses of products containing OPP are as disinfectants, antimicrobials, preservatives, antioxidants, and sanitizing solutions in various industries.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 2947, 1953 DOI: 10.1021/ja01108a047
Tetrahedron, 40, p. 4981, 1984 DOI: 10.1016/S0040-4020(01)91336-5
The Journal of Organic Chemistry, 26, p. 283, 1961 DOI: 10.1021/jo01060a632

General Description

Light lavender crystals or solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2-Phenylphenol react as a weak organic acid. Exothermically neutralizes bases. May react with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides to generate flammable gas (H2) and the heat of the reaction may ignite the gas. Is sulfonated very readily (for example, by concentrated sulfuric acid at room temperature) in exothermic reactions. May be nitrated very rapidly. Nitrated phenols often explode when heated and also form metal salts that tend toward detonation by rather mild shock. Can react with oxidizing agents .

Fire Hazard

2-Phenylphenol is combustible.

Agricultural Uses

Fungicide, Disinfectant, Microbiocide: Used to make fungicides. Also used to make dye stuffs and rubber chemicals, but used primarily as a disinfectant cleaner. Registered for use in the U.S. and U.K.

Trade name


Safety Profile

A poison by intraperitoneal route.Moderately toxic by ingestion and possibly other routes.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.Severe eye and moderate skin irritant. Questionablecarcinogen wi

Potential Exposure

o-Phenylphenol is used in the manufacture of plastics, resins, rubber, as Agricultural chemical, in making fungicides; as an intermediate in making dye stuffs and rubber chemicals; a germicide; used in food packaging.


IARC classified SOPP as a B2 carcinogen in 1983, based on reports from Japan that high dietary levels of this sodium salt caused bladder tumors in male rats. Both sodium saccharin and sodium cyclamate also cause bladder tumors at high doses in male rats, but classification of these food additives as B2 carcinogens was recently rescinded by IARC at a meeting in 1998.
The U.S. National Toxicology Program conducted a skin painting study with OPP in groups of 50 mice per sex. The OPP was applied as an acetone solution on 3 days per week for 2 years, both alone and as a promoter with DMBA. No skin neoplasms were observed in either sex treated with OPP alone, and there were no tumor enhancing or inhibiting effects when OPP and DMBA were given in combination.

Environmental Fate

Relevant Physicochemical Properties
Boiling point: 286 °C
Melting point: 59 °C
Log Kow: 3.09 at pH 7
Solubility: soluble in fixed alkali hydroxide solutions and most organic solvents; soluble in water at 700 mg l-1 at 25 °C
Vapor pressure: 2.0 × 10-3 mmHg at 25 °C
Henry’s law constant: 1.05 × 10-6 atm m3 mol-1 at 25 °C
Partition Behavior in Water, Sediment, and Soil
If released to air, OPP will exist solely as a vapor in the ambient atmosphere, and this vapor will be degraded by reaction with photochemically produced hydroxyl radicals. The half-life of the reaction is estimated to be 1.4 h. OPP absorbs light in the environmental UV spectrum and may undergo direct photolysis. If released to soil, OPP is expected to be immobile. Volatilization from moist soil surfaces may be an important fate process based on a Henry’s law constant of 1.5 × 10-6 atmm3 mol-1. If released into water, phenylphenol is expected to adsorb to sediment and suspended solids in water. Ground water contamination does not seem likely.
Environmental Persistence
The major degradation route appears to be through biodegradation in aerobic and anaerobic environments. The observed half-life values vary from 3 h to 3 weeks depending on the exposure site. Possibly hazardous short-term degradation products are not likely. However, long-term degradation products may arise. The products of degradation are less toxic than the product itself.
Bioaccumulation and Biomagnification
An estimated BCF of 51 was calculated for o-phenylphenol. This indicates that the potential for bioconcentration in aquatic organisms is moderate.

Metabolic pathway

2-Phenylphenol is not used on growing plants because it is too phytotoxic and there appears to be no information published on its metabolism in plants. Its widespread use as a preservative, disinfectant and fungistat on stored food (either by direct application or impregnated in packaging) requires studies on its environmental fate and metabolism in mammals. Several studies in mammals are available and the compound has been the subject of an evaluation by the UK MAFF Pesticide Safety Directorate (PSD); the results have been published (PSD, 1993). This evaluation was prompted by the discovery of bladder tumours in rats treated with high doses of the compound.
2-Phenylphenol is also used as the sodium and potassium salts where water solublity is important. No information is available specifically on the latter. The metabolism of the free phenol and the sodium salt have been studied separately. Once absorbed into a cell, provided that internal pH control is maintained, the two forms should be indistinguishable.


UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

Purification Methods

Crystallise it from pet ether. [Beilstein 6 IV 4579.]


2-Phenylphenol has limited water solubilty but it is very soluble in base, forming the alkali metal salts. It is a stable compound but it would be expected to react with oxygen to form quinones as do other phenols. The aqueous photolysis of 2-phenylphenol using a high pressure mercury vapour lamp gave phenyl-p-benzoquinone (2) and multi-hydroxylated products (see Scheme 1) (Coulangeon ef al., 1980). Degradation was accelerated by oxygen. The rate of degradation was not given in this paper, the main thrust of which was the primary physical steps in the photolysis process.
2-Phenylphenol was completely degraded during 14 days exposure to sunlight in aqueous solution under conditions where is was stable for 56 days in the dark (Suzuki et al., 1990). The objective of the study was to demonstrate the photogeneration of mutagens in the presence of nitrate and nitrite. Bacterial mutagens, probably nitro compounds, were formed only in the presence of nitrite.

Toxicity evaluation

OPP inhibits anabolism of many amino acids and highly downregulates the genes that encode the enzymes involved in the DAP pathway. Lysine and DAP are essential for building up the peptidoglycan cell wall. It was concluded that the mode of action of OPP is similar to the mechanismof action of some antibiotics.


Strong bases, strong oxidizers

Waste Disposal

In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

2-Phenylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

2-Phenylphenol Suppliers

Global( 335)Suppliers
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View Lastest Price from 2-Phenylphenol manufacturers

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2021-08-31 2-Phenylphenol
US $10.00 / Kg/Drum 1g/Bag 99%min 5000 Wuhan Monad Medicine Tech Co.,LTD
2021-08-26 2-Phenylphenol
US $15.00 / KG 1KG 99 1 ton Hebei Crovell Biotech Co Ltd
2021-08-10 2-Phenylphenol
US $1.00 / PCS 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

2-Phenylphenol Spectrum

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