2-Chloro-1,3,2-dioxaphospholane-2-oxide
- CAS No.
- 6609-64-9
- Chemical Name:
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide
- Synonyms
- 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE;ETHYLENE CHLOROPHOSPHATE;ETHYLENE CYCL-CHLOROPHOSPHATE;Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane);Ethylene chl;2-chloro-1,3,2;CYCLIC CHLOROPHOSPHATE;Ethylene chlorophosphate, tech. 90%;Ethylene glycol chlorophosphate, 95%;2-chloro-1,3,2λ?-dioxaphospholan-2-one
- CBNumber:
- CB0664909
- Molecular Formula:
- C2H4ClO3P
- Molecular Weight:
- 142.48
- MDL Number:
- MFCD00043138
- MOL File:
- 6609-64-9.mol
Melting point | 12-14 °C |
---|---|
Boiling point | 89-91 °C0.8 mm Hg(lit.) |
Density | 1.55 g/mL at 25 °C(lit.) |
vapor pressure | 1.06hPa at 25℃ |
refractive index |
n |
Flash point | >230 °F |
storage temp. | -20°C |
solubility | Chloroform (Soluble), Ethyl Acetate (Slightly) |
form | Solid or Film |
color | White to off-white |
Water Solubility | Miscible with water and chloroform. |
Sensitive | Moisture Sensitive |
BRN | 606582 |
Stability | Extremely moisture sensitive |
InChIKey | SBMUNILHNJLMBF-UHFFFAOYSA-N |
LogP | -0.485 at 25℃ and pH7 |
CAS DataBase Reference | 6609-64-9(CAS DataBase Reference) |
FDA UNII | 7EBS5ZK92N |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
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Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
Hazard Codes | C | |||||||||
Risk Statements | 14-34 | |||||||||
Safety Statements | 26-36/37/39-45-8-25-27 | |||||||||
RIDADR | UN 3265 8/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
F | 10 | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29209090 | |||||||||
NFPA 704 |
|
2-Chloro-1,3,2-dioxaphospholane-2-oxide price More Price(25)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 377953 | 2-Chloro-1,3,2-dioxaphospholane 2-oxide | 6609-64-9 | 5g | $154 | 2024-03-01 | Buy |
TCI Chemical | C1250 | 2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T) | 6609-64-9 | 5g | $85 | 2024-03-01 | Buy |
TCI Chemical | C1250 | 2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T) | 6609-64-9 | 25g | $261 | 2024-03-01 | Buy |
Alfa Aesar | A18320 | Ethylene chlorophosphate 95% | 6609-64-9 | 5g | $77.7 | 2023-06-20 | Buy |
Alfa Aesar | A18320 | Ethylene chlorophosphate 95% | 6609-64-9 | 25g | $290 | 2023-06-20 | Buy |
2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties,Uses,Production
Chemical Properties
clear colourless liquid
Uses
2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:
- 2-methacryloyloxyethylphosphorylcholine
- miltefosine (hexadecylphosphocholine, MT) analogs
- phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
- uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
- adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
- structurally related phospholipids which are either conformationally restricted or flexible
- phosphatidylcholines
Uses
Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.
Uses
2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.
General Description
2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.
Purification Methods
It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.]
2-Chloro-1,3,2-dioxaphospholane-2-oxide Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 | info@chemsigma.com | China | 1095 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12470 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15956 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
View Lastest Price from 2-Chloro-1,3,2-dioxaphospholane-2-oxide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-02-22 | 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
|
US $1000.00 / KG | 10g | 99% | 20tons | Hubei Langyou International Trading Co., Ltd | ||
2023-09-07 | 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | ||
2022-09-16 | 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
- US $1000.00 / KG
- 99%
- Hubei Langyou International Trading Co., Ltd
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
- 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.