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CYTISINE

Description References
CYTISINE
CYTISINE structure
CAS No.
485-35-8
Chemical Name:
CYTISINE
Synonyms
Tabax;Tabex;Ulexin;Citizin;Cytisin;Cytiton;Cytizin;ULEXINE;LABURNIN;(1R,5S)-
CBNumber:
CB1136805
Molecular Formula:
C11H14N2O
Formula Weight:
190.24
MOL File:
485-35-8.mol

CYTISINE Properties

Melting point:
154-156 °C(lit.)
Boiling point:
218 °C2 mm Hg(lit.)
alpha 
D17 -120°
Density 
1.0815 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
Store at RT
solubility 
439g/l
pka
6.11, 13.08(at 25℃)
form 
powder
color 
light yellow
optical activity
[α]/D -108±3°, c = 1% in ethanol
Merck 
14,2789
InChIKey
ANJTVLIZGCUXLD-DTWKUNHWSA-N
CAS DataBase Reference
485-35-8
NIST Chemistry Reference
Cytisine(485-35-8)
EPA Substance Registry System
1,5-Methano-8H-pyrido[ 1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-, (1R,5S)-(485-35-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  25-36/37/38
Safety Statements  26-28-36/37-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  HA4025000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29399990
Hazardous Substances Data 485-35-8(Hazardous Substances Data)
Toxicity LD50 in mice (mg/kg): 1.73 i.v.; 9.4 i.p.; 101 orally (Barlow, McLeod)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

CYTISINE price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 712264 Cytisine ≥99.0% (HPLC), ≥99% 485-35-8 100mg $161 2018-11-20 Buy
Sigma-Aldrich 712264 Cytisine ≥99.0% (HPLC), ≥99% 485-35-8 500mg $578 2018-11-20 Buy
TCI Chemical C2609 (-)-Cytisine >98.0%(GC)(T) 485-35-8 1g $581 2018-11-22 Buy
TCI Chemical C2609 (-)-Cytisine >98.0%(GC)(T) 485-35-8 100mg $115 2018-11-22 Buy
Sigma-Aldrich C2899 Cytisine ≥99%, powder 485-35-8 100mg $662 2018-11-20 Buy

CYTISINE Chemical Properties,Uses,Production

Description

Cytisine (also known as baptitoxine and sophorine) is a kind of naturally occurring alkaloid that can be found in several plant genera including Laburnum and Cytisus in the family Fabaceae. It has been shown that it is effective in the smoking cessation treatment. It is a low efficacy partial agonist of alpha4-beta2 nicotinic acetylcholine receptors, which is the central target of the nicotine that facilitates addiction. Cytisine is capable of reducing the effect of nicotine on dopamine release on the mesolimbic system as well as attenuating the nicotine withdrawal symptoms. Cytisine is also a useful reagent for organic chemistry such as being used for the manufacture of sparteine surrogate.

References

https://en.wikipedia.org/wiki/Cytisine
https://www.drugbank.ca/drugs/DB09028

Chemical Properties

Off-White to Tan Crystalline Solid

Uses

antiinflammatory, respiratory stimulant

Uses

Toxic priniciple in seed of Laburnum anagyroides and other Leguminosae. A neuronal nicotinic acetylcholine agonist

Uses

Cytisine occurs in the seeds of Cytisus labur num L. and other Leguminosae.

Definition

ChEBI: An organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as n aid to giving up smoking.

Health Hazard

Cytisine is highly toxic to humans and ani mals. Ingestions may cause nausea, vomiting,and convulsions. Death may occur from respiratory failure
LD50 value, oral (rats): 101 mg/kg.

Biological Activity

A potent, selective agonist at neuronal nicotinic receptors. Acts as a partial agonist at β 2-containing nicotinic receptors.

Purification Methods

Crystallise cytisine from acetone and sublime it in a vacuum. Its solubilities are: 77% (H2O), 7.7% (Me2CO), 28.6% (EtOH), 3.3% (*C6H6), 50% (CHCl3) but it is insoluble in pet ether. The tartrate has m 206-207o [] D +45.9o, the N-tosylate has m 206-207o, and the N-acetate has m 208o. [Bohlmann et al. Angew Chem 67 708 1955, van Tamelen & Baran J Am Chem Soc 77 4944 1955, Isolation: Ing J Chem Soc 2200 1931, Govindachari et al. J Chem Soc 3839 1957, Abs config: Okuda et al. Chem Ind (London) 1751 1961, Beilstein 24 H 134, 24 I 244, 24 II 70, 24 III/IV 321.] TOXIC.

CYTISINE Preparation Products And Raw materials

Raw materials

Preparation Products


CYTISINE Suppliers

Global( 237)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3202 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21915 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20675 55
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 211 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4002 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25795 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2236 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 308 58

View Lastest Price from CYTISINE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-11 Cytisine 485-35-8
485-35-8
US $20.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2019-07-11 Cytisine 485-35-8
485-35-8
US $20.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2018-12-16 CYTISINE
485-35-8
US $8.00 / kg 1kg 98% 10MT career henan chemical co

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