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Teneligliptin

Teneligliptin
Teneligliptin structure
CAS No.
906093-29-6
Chemical Name:
Teneligliptin
Synonyms
Teneligliptin HBr;MP-513 (hydrobromide);Teneligliptin (hydrobroMide);Teneligliptin HydrobroMide (2:5);Teneligliptin HydrobroMide Hydrate;Teneligliptin hydrobromide anhydrous;API(Teneligliptin hydro bromide hydrate);TENELIGLIPTIN HEMIPENTA HYDROBROMIDE HYDRATE;((2S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5)
CBNumber:
CB12666692
Molecular Formula:
C22H31BrN6OS
Formula Weight:
507.5
MOL File:
906093-29-6.mol

Teneligliptin Properties

CAS DataBase Reference
906093-29-6
FDA UNII
15S4OCS6SS

Teneligliptin Chemical Properties,Uses,Production

Clinical Use

Teneligliptin is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name Tenelia®. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1 levels, with very low rates of renal excretion.

Chemical Synthesis

The only reported synthesis of teneligliptin is described in the scheme below. Reaction of commercially available N-Boc-piperazine (158) with diketene (159) in DMF at room temperature gave acetoacetamide 160 in 86% yield, and this material was immediately condensed with phenylhydrazine in methanesulfonic acid followed by a cyclodehydration with phosphorus oxychloride to give pyrazole 161 in 12% yield. The t-butyl carbamate was then removed with TFA in dichloromethane to give amine 162 in 88% yield. This amine was then subjected to butyrolactam 165 (which was prepared from N-Boctrans- 4-hydroxy-L-proline (163) coupled with thiazolidine (164) under conventional amide-forming conditions using EDC) in the presence of sodium triacetoxy borohydride (STAB-H) in acetic acid. This reductive amination reaction afforded the cis-aminopyrrolidine 166 exclusively in 50% yield. Removal of the t-butyl carbamate group with TFA afforded the teneligliptin free amine in 93% yield, and this freebase was then subsequently treated with 48% hydrobromic acid in refluxing ethanol to give teleligliptin hydrobromide hydrate (XXV) in 90% yield.

Teneligliptin Preparation Products And Raw materials

Raw materials

Preparation Products


Teneligliptin Suppliers

Global( 119)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20903 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26762 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Teneligliptin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-07-10 Teneligliptin
906093-29-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06 Teneligliptin
906093-29-6
US $7.00 / kg 1kg 99% 100kg career henan chemical co

906093-29-6(Teneligliptin)Related Search:


  • [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide
  • API(Teneligliptin hydro bromide hydrate)
  • 3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O
  • Teneligliptin (hydrobroMide)
  • Teneligliptin HydrobroMide Hydrate
  • 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5)
  • Teneligliptin HydrobroMide (2:5)
  • Teneligliptin HBr
  • MP-513 (hydrobromide)
  • Teneligliptin hydrobromide anhydrous
  • TENELIGLIPTIN HEMIPENTA HYDROBROMIDE HYDRATE
  • ((2S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone
  • 906093-29-6
  • C44H65Br5N12O2S2
  • 2C22H30N6OS5HBr
  • 2C22H30N6OS5BrH
  • API
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