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Teneligliptin

Teneligliptin Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Teneligliptin
CAS:906093-29-6
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Teneligliptin
CAS:906093-29-6
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Teneligliptin
CAS:906093-29-6
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 E-mail:sales03@shyrchem.com
Email: sales03@shyrchem.com
Products Intro: Product Name:Teneligliptin Hydrobromide
CAS:906093-29-6
Purity:0.98 Package:100g;250g;500g;1kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:906093-29-6
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Lastest Price from Teneligliptin manufacturers

  • Teneligliptin
  • US $15.00-10.00 / KG
  • 2021-07-10
  • CAS:906093-29-6
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Teneligliptin
  • US $7.00 / kg
  • 2019-07-06
  • CAS: 906093-29-6
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Teneligliptin Basic information
Product Name:Teneligliptin
Synonyms:[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone,pentahydrobromide;API(Teneligliptin hydro bromide hydrate);3-(((2s,4s)-4-(4-(3-Methyl-1-phenyl-1h-pyrazol-5-yl)-1-piperazinyl)-2-pyrrolidinyl)carbonyl)-thiazolidine hydrobromide (2:5) X H2O;Teneligliptin (hydrobroMide);Teneligliptin HydrobroMide Hydrate;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]-thiazolidine hydrobromide (2:5);Teneligliptin HydrobroMide (2:5);Teneligliptin HBr
CAS:906093-29-6
MF:C22H31BrN6OS
MW:507.5
EINECS:
Product Categories:API
Mol File:906093-29-6.mol
Teneligliptin Structure
Teneligliptin Chemical Properties
Safety Information
MSDS Information
Teneligliptin Usage And Synthesis
Clinical UseTeneligliptin is a DPP-4 inhibitor which was approved in Japan in 2012 for the treatment of type II diabetes. It was discovered and developed by Mitsubishi Tanabe Pharma under the trade name Tenelia®. Similar to other marketed DPP-4 inhibitors, teneligliptin was well tolerated in all studies and QD dosing produced a long-lasting inhibitory action against DPP-4 and an increase in active GLP-1 levels, with very low rates of renal excretion.
Chemical SynthesisThe only reported synthesis of teneligliptin is described in the scheme below. Reaction of commercially available N-Boc-piperazine (158) with diketene (159) in DMF at room temperature gave acetoacetamide 160 in 86% yield, and this material was immediately condensed with phenylhydrazine in methanesulfonic acid followed by a cyclodehydration with phosphorus oxychloride to give pyrazole 161 in 12% yield. The t-butyl carbamate was then removed with TFA in dichloromethane to give amine 162 in 88% yield. This amine was then subjected to butyrolactam 165 (which was prepared from N-Boctrans- 4-hydroxy-L-proline (163) coupled with thiazolidine (164) under conventional amide-forming conditions using EDC) in the presence of sodium triacetoxy borohydride (STAB-H) in acetic acid. This reductive amination reaction afforded the cis-aminopyrrolidine 166 exclusively in 50% yield. Removal of the t-butyl carbamate group with TFA afforded the teneligliptin free amine in 93% yield, and this freebase was then subsequently treated with 48% hydrobromic acid in refluxing ethanol to give teleligliptin hydrobromide hydrate (XXV) in 90% yield.

Teneligliptin Preparation Products And Raw materials
Tag:Teneligliptin(906093-29-6) Related Product Information
Levofloxacin hydrochloride ALOGLIPTIN(ALOGLIPTINE, ALOGLIPTINA) Teneligptin API 1-Pyrrolidinecarboxylic acid, 4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-(3-thiazolidinylcarbonyl)-, 1,1-dimethylethyl ester, (2S,4R)- 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbonyl)-, 1,1-diMethylethyl ester, (2R)- Unii-4bmh7izt98 Aprepitant Repaglinide Calcium levofolinate Sofosbuvir Levetiracetam Rivaroxaban AGOMELATINE Linagliptin Alogliptin benzoate Trelagliptin TAK-438 Trelagliptin succinate