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Alogliptin benzoate

Indications and Usage Mechanisms of Action Adverse reactions
Alogliptin benzoate
Alogliptin benzoate structure
Chemical Name:
Alogliptin benzoate
Nesina;CS-247;SYR 322;Aglitin API;Alogliptin API;NESINA; SYR 322;benjisuanageliedin;Alogiptin Benzoate;ALOGLIPTIN BENZOATE;Benzoic acid, Glenn
Molecular Formula:
Formula Weight:
MOL File:

Alogliptin benzoate Properties


Alogliptin benzoate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23768 Alogliptin (benzoate salt) ≥98% 850649-62-6 25mg $44 2021-03-22 Buy
Cayman Chemical 23768 Alogliptin (benzoate salt) ≥98% 850649-62-6 50mg $84 2021-03-22 Buy
Cayman Chemical 23768 Alogliptin (benzoate salt) ≥98% 850649-62-6 100mg $158 2021-03-22 Buy
Cayman Chemical 23768 Alogliptin (benzoate salt) ≥98% 850649-62-6 250mg $330 2021-03-22 Buy

Alogliptin benzoate Chemical Properties,Uses,Production

Indications and Usage

Alogliptin (benzoic acid) is a type-2 diabetes medication, and it is a type of serine protease dipeptidyl peptidase IV (DPP-4) inhibitor developed by the Japanese company Takeda. Alogliptin, used alone or in combination with other blood sugar-lowering medication, is usually well-tolerated in type-2 diabetes patients. This medication has a low risk of hypoglycemia, with Alogliptin treatment groups ≤8.3% and placebo groups ≤10.5%, and shows no difference between young and elderly patients. In addition to effectively lowering blood sugar, this medicine also lowers the risks of hypoglycemia and weight increase, overcoming great obstacles in patient treatment and providing new hope for diabetes treatment.

Mechanisms of Action

Alogliptin selectively inhibits DPP-4 to reduce the inactivation of glucagon-like peptide 1 (GLP-1) and increase the GLP-1 levels in the body, thus lowering blood sugar. Once blood sugar reaches normal levels, it will cease its sugar-lowering effects, thus effectively reducing the risks of hypoglycemia. Additionally, DPP-4 inhibitor also slows gastric emptying, increases the feeling of fullness, and controls appetite, thus helping patients control their weight.

Adverse reactions

Common side effects of Alogliptin include nasopharyngitis, headaches, and upper respiratory tract infection. Most side effects are light to moderate and are unrelated to dosage.


Treatment of type 2 diabetes.


ChEBI: A benzoate salt obtained by combining equimolar amounts of alogliptin and benzoic acid. Used for treatment of type 2 diabetes.

Clinical Use

Alogliptin benzoate is a dipeptidyl peptidase IV (DPPIV) inhibitor discovered by Takeda Pharmaceuticals and approved in Japan in 2010 for the treatment of type II diabetes mellitus. Alogliptin is an oral drug for once a day dosing to complement diet and exercise. Alogliptin is the most selective marketed DPPIV inhibition and has similar PK and PD properties compared to previous entries. The discovery, structure-activity relationship of related analogs, and synthesis of this compound have been recently published.

Chemical Synthesis

The most convenient synthesis for scale-up will be highlighted from several published routes. Commercially available 2-cycanobenzyl amine 1 was reacted with methylisocyanate in DCM at ambient temperature to provide N-methyl urea 2 in 85% yield. Reaction of the urea 2 with dimethyl malonate in refluxing ethanol with sodium ethoxide as base gave the cyclized trione 3 in 78-85% yield. The trione 3 was then refluxed in neat POCl3 to provide the penultimate chloride crude 4 in 95% yield which was reacted with Boc-protected diamine 5 in the presense of potassium carbonate in DMF to furnish alogliptin I in 93-96% yield. Treatment of alogliptin with benzoic acid in ethanol at 60-70 °C followed by crystallization delivered the desired alogliptin benzoate (I).

Alogliptin benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

Alogliptin benzoate Suppliers

Global( 403)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Ande Pharmaceutical Co.,Ltd.
+8613256107535 CHINA 220 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 20903 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
+86-571-56059825 CHINA 8909 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 CHINA 3013 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-34979012 CHINA 739 60
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 26762 60
Anqing Chico Pharmaceutical Co., Ltd.
15380796838 CHINA 341 58
Lianyungang happen teng technology co., LTD
15950718863 CHINA 296 58
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967 CHINA 1009 58

View Lastest Price from Alogliptin benzoate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-06 Alogliptin Benzoate
US $10.00 / KG 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2021-12-06 Alogliptin benzoate
US $1.00 / KG 1KG 99% 100 Jinan Ande Pharmaceutical Co.,Ltd.
2021-11-15 Alogliptin Benzoate
US $29.00 / KG 1KG 99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd

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