HOE 140
- CAS No.
- 130308-48-4
- Chemical Name:
- HOE 140
- Synonyms
- S-0765;H0E-140;HOE I40;HOE 140;JE-049);Etibant;Icatibant;HOE 140 TFA;Icatibant [inn];HOE 140 USP/EP/BP
- CBNumber:
- CB1318492
- Molecular Formula:
- C59H89N19O13S
- Molecular Weight:
- 1304.52
- MDL Number:
- MFCD00213940
- MOL File:
- 130308-48-4.mol
- MSDS File:
- SDS
Density | 1.60±0.1 g/cm3(Predicted) |
---|---|
storage temp. | Sealed in dry,2-8°C |
solubility | Water:100.0(Max Conc. mg/mL);76.66(Max Conc. mM) |
form | powder |
pka | 3.60±0.21(Predicted) |
color | white |
Water Solubility | Soluble to 1 mg/ml in water |
Sequence | H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH |
InChIKey | QASONHYHOCRAHL-DOMVFXHKSA-N |
CAS DataBase Reference | 130308-48-4 |
FDA UNII | 7PG89G35Q7 |
ATC code | B06AC02 |
HOE 140 price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 3014 | HOE 140 | 130308-48-4 | 500U | $227 | 2021-12-16 | Buy |
Usbiological | 255460 | HOE 140 | 130308-48-4 | 500ug | $480 | 2021-12-16 | Buy |
ChemScene | CS-3381 | Icatibant 99.51% | 130308-48-4 | 5mg | $540 | 2021-12-16 | Buy |
AK Scientific | 3729AH | Icatibant | 130308-48-4 | 5mg | $610 | 2021-12-16 | Buy |
Apolloscientific | BISN0006 | Icatibant 98% | 130308-48-4 | 5mg | $660 | 2021-12-16 | Buy |
HOE 140 Chemical Properties,Uses,Production
Description
Hoe 140 (D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin), on bradykinin- and platelet-activating factor (PAF)-induced bronchoconstriction and airway microvascular leakage in anesthetized guinea pigs. Hoe 140 is highly potent and long-acting in inhibiting BK-induced hypotensive responses in the rat. Four hours after s.c. administration of 20nmol kg-1, inhibition still amounted to 60% whereas the effect of 200nmol kg-1 of d-Arg-[Hyp2, Thi5,8, d-Phe7]BK was not significant[1-2].
Uses
Antagonist (bradykinin).
Definition
ChEBI: A ten-membered synthetic oligopeptide consisting of D-Arg, Arg, Pro, Hyp, Gly, Thi, Ser, D-Tic, Oic, and Arg residues joined in sequrence. A bradykinin receptor antagonist used as its acetate salt for the treatment of acut attacks of hereditary angioedema in adult patients.
brand name
Metastat (CollaGenex).
storage
Store at -20°C
References
[1] K. Wirth. “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies.” British Journal of Pharmacology 102 3 (1991): 774–777.
[2] T Sakamoto. “Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig.” European journal of pharmacology 213 3 (1992): 367–73.
HOE 140 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10991 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Alpha Biopharmaceuticals Co., Ltd | +86-15542445688 | sales@alabiochem.com | China | 884 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10311 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29822 | 58 |
View Lastest Price from HOE 140 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-24 | HOE 140
130308-48-4
|
US $50.00-500.00 / g | 10g | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-19 | Icatibant
130308-48-4
|
US $50.00 / box | 1box | >99% | tons | Hong Kong Excellence Biotechnology Co., Ltd. | ||
2024-08-27 | HOE 140
130308-48-4
|
US $85.00-850.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
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