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Busulfan structure
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Busulfan Properties

Melting point:
114-117 °C(lit.)
Boiling point:
359.3°C (rough estimate)
1.305 (estimate)
refractive index 
1.5630 (estimate)
Flash point:
storage temp. 
Hygroscopic, Refrigerator, Under Inert Atmosphere
Very slightly soluble in water, freely soluble in acetone and in acetonitrile, very slightly soluble in ethanol (96 per cent).
Crystalline Powder
Pale Brown
Water Solubility 
Moisture Sensitive
CAS DataBase Reference
55-98-1(CAS DataBase Reference)
EPA Substance Registry System
1,4-Butanediol, dimethanesulfonate(55-98-1)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H300-H225-H301+H311+H331-H370-H301-H310+H330-H350-H310-H330
Precautionary statements  P202-P261-P264-P270-P271-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501-P210-P260-P280-P301+P310-P311-P201-P302+P352+P310-P304+P340+P310-P308+P313-P284-P302+P350-P301+P310a-P304+P340-P320-P330-P501a
Hazard Codes  T+,T,F
Risk Statements  45-26/27/28-63-46-36/37/38-23/24/25-39/23/24/25-11
Safety Statements  53-36/37/39-45-28A-36/37-16-7
RIDADR  UN 2811 6.1/PG 1
WGK Germany  3
RTECS  EK1750000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29053990
Toxicity LD50 i.v. in rats: 1.8 mg/kg (Scherf)

Busulfan price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B2635 Busulfan analytical standard, for drug analysis 55-98-1 10g $29.9 2018-11-20 Buy
Sigma-Aldrich B-058 Busulfan solution 55-98-1 058-1ml $197 2018-11-20 Buy
TCI Chemical B1022 1,4-Butanediol Dimethanesulfonate >97.0%(T) 55-98-1 25g $55 2018-11-22 Buy
Alfa Aesar J61348 Busulfan, 98% 55-98-1 5g $19.1 2018-11-13 Buy
Cayman Chemical 14843 Busulfan ≥98% 55-98-1 50g $74 2018-11-13 Buy

Busulfan Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid


Alkylating agent with antileukemic activity. Antineoplastic


Antineoplastic alkylating agent, the palliative treatment of chronic myeloid leukemia, and insect sterilant.


ChEBI: A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.


Busulfan (Myleran) is a bifunctional methanesulfonic ester that forms intrastrand cross-linkages with DNA. The drug is well absorbed after oral administration and has a plasma half-life of less than 5 minutes. Metabolites and degradation products are excreted primarily in the urine.
Busulfan is used in the palliative treatment of chronic granulocytic leukemia. Daily oral therapy results in decreased peripheral white blood cells and improved symptoms in almost all patients during the chronic phase of the disease. Excessive uric acid production from rapid tumor cell lysis should be prevented by coadministration of allopurinol.
At usual therapeutic dosages, busulfan is selectively toxic to granulocyte precursors rather than lymphocytes. Thrombocytopenia and anemia and less commonly, nausea, alopecia, mucositis, and sterility also may occur. Unusual side effects of busulfan include gynecomastia, a general increase in skin pigmentation, and interstitial pulmonary fibrosis.

brand name

Myleran (GlaxoSmithKline).

General Description

White crystals or powder.

General Description

As an alternative to utilizing aziridines as electrophilic species,it was found that simply utilizing a carbon chain terminated atboth ends by leaving groups gave compounds capable of actingas cross-linking agents.Busulfan utilizestwo sulfonate functionalities as leaving groups separated by afour-carbon chain that reacts with DNA to primarily form intrastrandcross-link at 5'-GA-3' sequences.The sulfonatesare also subject to displacement by the sulfhydryl functionsfound in cysteine and glutathione, and metabolic products areformed as a result of nucleophilic attack by these groups togenerate sulfonium species along with methane sulfonicacid.This is followed by conversion to tetrahydrothiophene,and further oxidation products are subsequently produced togive the sulfoxide and sulfone. The cyclic sulfone known assulfolane may be further oxidized to give 3-hydroxysulfolane.

General Description

Busulfan is available as 2-mg tablets for oral administrationand 10-mL vials for IV administration in the treatment ofchronic myelogenous leukemia (CML) and in high-dosetherapy for refractory leukemia with bone marrow transplant.The agent is well absorbed when given orally, well distributedinto tissues, and crosses the blood-brain barrier.Metabolism occurs in the liver to give mainly methane sulfonic acid by the action of glutathione-S-transferase. Other identified metabolites in humanshave included tetrahydrothiophene-1-oxide, sulfalene,primarily in the urine, and the terminal elimination half-lifeis 2.5 hours. Adverse effects include dose-limiting myelosuppression;nausea and vomiting that occur commonly butare generally mild; and pulmonary symptoms including interstitialpulmonary fibrosis, which is referred to as “busulfanlung,” occurs belatedly (1–10 years posttreatment) andalthough rare, it is severe. Other adverse effects includemucositis, skin rash, impotence, amenorrhea, infertility, hepatoxicity,insomnia, anxiety, and an increased risk of secondarymalignancies. At normal doses, the agent is welltolerated except for the myelosuppression that occurs. Thishas allowed for high-dose therapy with the agent when accompaniedby bone marrow transplant to counter the myelosuppressiveeffects.

Air & Water Reactions

Busulfan is an alkylating agent which hydrolyzes in water. .

Reactivity Profile

Busulfan is an alkylating agent which hydrolyzes in water. . Strong reducers may yield hydrogen sulfide.


Extremely toxic, carcinogen, clastogenic, teratogenic, immunosuppressive, delayed bone marrow aplasia, cataracts, pigmentation, pulmonary thrombosis, cardiotoxic effects, thrombocytopenia.

Fire Hazard

Flash point data for Busulfan are not available. Busulfan is probably combustible.

Safety Profile

Confirmed carcinogen producing leukemia, kidney, and uterine tumors. Experimental neoplastigenic and tumorigenic data. Poison by ingestion, subcutaneous, intraperitoneal, intravenous, and possibly other routes. Ingestion by pregnant women can cause cancer of the reproductive system of the fetus includtng the uterus. Human teratogenic effects by ingestion and possibly other routes include developmental abnormaltties of the eye, ear, craniofacial area including the nose and tongue, gastrointestinal system, endocrine system, urogenital system, and other unspecified areas. Other human reproductive effects by ingestion and possibly other routes include: impotence, changes in the uterus, cervix, and vagina, and menstrual-cycle dtsorders. Experimental reproductive effects. Human systemic effects by ingestion: general arteriolar or venous ddation of the eye, changes in structure or function of salivary glands. When heated to decomposition it emits toxic fumes of SOx. See also SULFONATES.

Veterinary Drugs and Treatments

Busulfan may be useful in the adjunctive therapy of chronic granulocytic leukemias or polycythemia vera in small animals. Not commonly used in veterinary medicine.


1,4-Butanediol dimethanesulfonate is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.


Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Food and Drug Administration (FDA)
Regulated as a prescription drug subject to labeling and other requirements.

Busulfan Preparation Products And Raw materials

Raw materials

Preparation Products

Busulfan Suppliers

Global( 185)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21696 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32447 55
career henan chemical co
+86-371-86658258 CHINA 30001 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28236 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6372 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23049 58
BOC Sciences
1-631-614-7828 United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 35440 58

View Lastest Price from Busulfan manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-08 Busulfan
US $1.00 / KG 1KG 98% 1tons career henan chemical co

Busulfan Spectrum

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