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Chemical Name:
DMDT;MeOCl;Metox;Moxie;oms466;mezoxk;Marlate;OMS 466;Mesox K;Methoxo
Molecular Formula:
Formula Weight:
MOL File:


Melting point:
86-88 °C(lit.)
1.41 g/cm3 (25℃)
Flash point:
11 °C
storage temp. 
Exposure limits
NIOSH REL: IDLH 5,000 mg/m3; OSHA PEL: TWA 15 mg/m3; ACGIH TLV: TWA 10 mg/m3.
Stable, but light sensitive. Combustible at high temperature. Corrodes aluminium and iron slowly.
CAS DataBase Reference
72-43-5(CAS DataBase Reference)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F,N
Risk Statements  20/21/22-40-39/23/24/25-23/24/25-11-67-65-50/53-38
Safety Statements  7-23-36/37/39-45-16-62-61-60-33-29-9-36/37
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  KJ3675000
HazardClass  9
PackingGroup  III
Toxicity LD50 orally in rats: 5.0 g/kg (Hodge)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H304 May be fatal if swallowed and enters airways Aspiration hazard Category 1 Danger
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P331 Do NOT induce vomiting.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P405 Store locked up.
P501 Dispose of contents/container to..…

METHOXYCHLOR price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 36161 Methoxychlor PESTANAL 72-43-5 100mg $41.2 2018-11-20 Buy
Sigma-Aldrich 48982 Methoxychlor solution 200 μg/mL in isooctane, analytical standard 72-43-5 48982 $48.9 2018-11-23 Buy
Alfa Aesar J63839 Methoxychlor 72-43-5 5g $28.3 2018-11-13 Buy
Alfa Aesar J63839 Methoxychlor 72-43-5 25g $141 2018-11-13 Buy
Sigma-Aldrich 49054 Methoxychlor analytical standard 72-43-5 49054 $116 2018-11-23 Buy

METHOXYCHLOR Chemical Properties,Uses,Production

Chemical Properties

Methoxychlor is a colourless or pale yellow, crystalline synthetic organochlorine insecticide with mild fruity odour. It is available in the form of powder or crystals. Methoxychlor is moderately soluble in water and is soluble in a variety of organic solvents.


Insecticide effective against mosquito larvae and house flies; recommended for use in dairy barns.


Insecticide used to control mosquito larvae, house flies and other insect pests in field crops, fruits and vegetables; to control ecto-parasites on cattle, sheep and goats; recommended for use in dairy barns.

General Description

METHOXYCHLOR is a white crystalline solid which is often dissolved in a liquid carrier such as diesel oil. METHOXYCHLOR can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. If dissolved in a liquid carrier, METHOXYCHLOR can easily penetrate the soil and contaminate groundwater and nearby streams. METHOXYCHLOR is used as a pesticide.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

METHOXYCHLOR turns pink or tan on exposure to light. METHOXYCHLOR is incompatible with alkaline materials, especially in the presence of catalytically-active metals. METHOXYCHLOR is slightly corrosive to iron and aluminum. METHOXYCHLOR is decomposed by refluxing with sodium in isopropyl alcohol. METHOXYCHLOR is also incompatible with strong oxidizers. METHOXYCHLOR will attack some forms of plastics, rubber and coatings. .


Toxic material. Liver damage and central nervous system impairment. Questionable carcinogen.

Health Hazard

Low toxicity; acute and chronic effects aremuch less serious than those of the structurally similar DDT; skin absorption low;may cause kidney damage on chronic exposure; oral LD50 value (rats): 6000 mg/kg(ACGIH 1986); no evidence of carcinogenicity to animals or humans; exposure limit:TLV-TWA 10 mg/m3 (ACGIH, MSHA, andOSHA); RCRA Waste Number U247
Methoxychlor is a reproductive toxicant.Exposure of young adult male rats to methoxychlor reduced their serum testosterone levels (Murono et al. 2006). It metabolized in theliver into 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane and both methoxychlor and itsmetabolite were found to exhibit weak estrogenic and antiandrogenic activities. Flynnet al. (2005) have reported that long-termexposure to methoxychlor in diet altered thesexually dimorphic behavior in young ratsof both sexes. The study indicated that consumption of sodium solution increased in ratsfrom such exposure. The toxicity of methoxychlor, particularly in the central nervous system, may be attributed to its inhibition of brainmitochondrial respiration which probably iscaused by an increased production of reactiveoxygen species (Schuh et al. 2005).

Health Hazard

Toxicity is relatively low. Inhalation or ingestion causes generalized depression.

Fire Hazard

Special Hazards of Combustion Products: Irritating and toxic hydrogen chloride gas may be formed in fire.

Agricultural Uses

Insecticide: Not approved for use in EU countries . Not registered for use in the U.S. There are 33 global suppliers . The U.S. EPA lists 826 active and/or canceled products containing methoxychlor. Methoxychlor was introduced as an insecticide in 1945. It is a close relative of DDT and has been increasing in use since the ban on DDT in 1972 because of its very low mammalian toxicity for home and garden, on domestic animals for fly control, for elm bark-beetle vectors of Dutch elm disease, and for blackfly larvae in streams. Methoxychlor is registered for about 87 crops such as alfalfa; nearly all fruits and vegetables, corn, wheat, rice, and other grains; beef and dairy cattle; and swine, goats and sheep, and for agricultural premises and outdoor fogging. It is available in wettable and dust powders, emulsifiable concentrates, granules, and as an aerosol. It is combined in formulations with malathion, parathion, piperonyl butoxide, and pyrethrins.

Trade name


Safety Profile

Suspected carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Moderately toxic by intraperitoneal and skin contact routes. Human systemic effects by skin contact: somnolence. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits highly toxic fumes of Cl-. See also DDT and CHLOROPHENOLS.

Environmental Fate

Biological. Degradation by the microorganism Aerobacter aerogenes under aerobic or anaerobic conditions yielded 1,1-dichloro-2,2-bis(p-methoxyphenyl)ethylene and 1,1- dichloro-2,2-bis(p-methoxyphenyl)ethane (Mendel and Walton, 1966; Kobayashi and Rittman, 1982). Methoxychlor degrades at a faster rate in flooded/anaerobic soils than in nonflooded and aerobic soils (Fogel et al., 1982; Golovleva et al., 1984). In anaerobic soil, 90% of the applied dosage was lost after 3 months. In aerobic soil, only 0.3% was lost as carbon dioxide after 410 days (Fogel et al., 1982). In a modified river die-away test, methoxychlor underwent aerobic biodegradation at a rate of 0.0024/hour which corresponds to a half-life of 12 days (Cripe et al., 1987).
In a model aquatic ecosystem, methoxychlor degraded to ethanol, dihydroxyethane, dihydroxyethylene and unidentified polar metabolites (Metcalf et al., 1971). Kapoor et al. (1970) also studied the biodegradation of methoxychlor in a model ecosystem contain
From the first-order biotic and abiotic rate constants of methoxychlor in estuarine water and sediment/water systems, the estimated biodegradation half-lives were 208–8,837 and 12–45 days, respectively (Walker et al., 1988).
Paris and Lewis (1976) reported that the microorganism Aspergillis sp. accumulated methoxychlor slowly, requiring 16 hours to reach equilibrium. Some microorganisms, such as Flavobacterium harrisonii, Bacillus subtilis and Chlorella pyrenoidoda accumulated methoxychlor and reached equilibrium in only 30 minutes.
Groundwater. According to the U.S. EPA (1986) methoxychor has a high potential to leach to groundwater.

Metabolic pathway

Upon UV irradiation with methyl oleate, methoxychlor is extensively added to the carbon ? carbon double bond of methyl oleate via radical mechanisms. Besides chlorinated stearic acids, several addition products are formed, offering new possibilities to produce bound residues in plants. The incubation of methoxychlor with liver microsomes from untreated and phenobarbital-treated rats and donors, in the presence of NADPH, yields three phenolic metabolites: monodemethylated and didemethylated methoxychlor and its hydroxylated (trihydroxy) methoxychlor. The metabolic route of methoxychlor by monooxygenases involves sequential demethylations to the dihydroxy derivative and a subsequent ring hydroxylation.

Purification Methods

Free the insecticide from 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane by crystallising from EtOH. It is dimorphic and also crystallises from Et2O/EtOH (m 92o). [Fritsch & Feldmann Justus Liebigs Ann Chem 306 77 1899, Smith et al. Aust J Chem 29 743 1976, Beilstein 6 H 1007.]

METHOXYCHLOR Preparation Products And Raw materials

Raw materials

Preparation Products


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