STAUROSPORINE
- CAS No.
- 62996-74-1
- Chemical Name:
- STAUROSPORINE
- Synonyms
- STSP;AM-2282;Staurosporin;Stauroporine;CBR113;CS-2206;Sporosin;CGP 39360;CCRIS 3272;Astrosporin
- CBNumber:
- CB2486697
- Molecular Formula:
- C28H26N4O3
- Molecular Weight:
- 466.54
- MDL Number:
- MFCD18252446
- MOL File:
- 62996-74-1.mol
Melting point | 270°C |
---|---|
alpha | D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol) |
Boiling point | 677.5±55.0 °C(Predicted) |
Density | 1.56±0.1 g/cm3(Predicted) |
RTECS | KD5084000 |
storage temp. | 2-8°C |
solubility | DMSO: soluble |
form | White to pale yellow solid |
pka | 14.25±0.70(Predicted) |
color | Off white to pale yellow |
Water Solubility | Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water. |
BRN | 1060573 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months. |
InChIKey | HKSZLNNOFSGOKW-WIFUGMKFSA-N |
CAS DataBase Reference | 62996-74-1 |
NCI Dictionary of Cancer Terms | staurosporine |
FDA UNII | H88EPA0A3N |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS08 |
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Signal word | Warning | |||||||||
Hazard statements | H361d-H413 | |||||||||
Precautionary statements | P201-P202-P273-P280-P308+P313-P405 | |||||||||
Hazard Codes | Xn,T,Xi | |||||||||
Risk Statements | 40-45-36/37/38-46 | |||||||||
Safety Statements | 36/37-53-36-26-45 | |||||||||
RIDADR | UN 2811 6.1 / PGII | |||||||||
WGK Germany | 2 | |||||||||
F | 8-10 | |||||||||
HazardClass | 3 | |||||||||
HS Code | 29419090 | |||||||||
NFPA 704 |
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STAUROSPORINE price More Price(53)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | S5921 | Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC) | 62996-74-1 | 0.1mg | $307 | 2024-03-01 | Buy |
Sigma-Aldrich | S5921 | Staurosporine from Streptomyces sp. for molecular biology, ≥95% (HPLC) | 62996-74-1 | 0.5mg | $883 | 2024-03-01 | Buy |
Sigma-Aldrich | S4400 | Staurosporine from Streptomyces sp. ≥98% (HPLC), film | 62996-74-1 | 0.1mg | $223.2 | 2024-03-01 | Buy |
Sigma-Aldrich | S4400 | Staurosporine from Streptomyces sp. ≥98% (HPLC), film | 62996-74-1 | 0.5mg | $802 | 2024-03-01 | Buy |
Sigma-Aldrich | 569397 | Staurosporine, Streptomyces sp. Staurosporine,CAS62996-74-,isacell-permeable,potent,reversible,ATP-compe | 62996-74-1 | 100μg | $159 | 2024-03-01 | Buy |
STAUROSPORINE Chemical Properties,Uses,Production
Description
Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-
Chemical Properties
Light Yellow Solid
Occurrence
A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.
Uses
Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.
Uses
Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.
Definition
ChEBI: Staurosporine is an indolocarbazole alkaloid and an organic heterooctacyclic compound. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a geroprotector, a bacterial metabolite and an apoptosis inducer. It is a conjugate base of a staurosporinium.
General Description
A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.
Biological Activity
Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .
Biochem/physiol Actions
Reversible: yes
storage
+4°C
References
1) Omura et al. (1977) A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization; J. Antibiot., 30 275 2) Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases; Trends in Pharmacological Science 10 218
STAUROSPORINE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ENBRIDGE PHARMTECH CO., LTD. | +8613812269233 | tinayang@enbridgepharm.com | China | 302 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12465 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9294 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8820 | 58 |
View Lastest Price from STAUROSPORINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-18 | staurosporine
62996-74-1
|
US $1.00 / g | 1g | ≥98% | 20kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
2024-04-23 | Staurosporine
62996-74-1
|
US $5.00 / kg | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd | ||
2024-04-05 | STAUROSPORINE
62996-74-1
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
- staurosporine
62996-74-1
- US $1.00 / g
- ≥98%
- WUHAN FORTUNA CHEMICAL CO., LTD
- Staurosporine
62996-74-1
- US $5.00 / kg
- 99.92%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
- STAUROSPORINE
62996-74-1
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
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